Evaluation of risk factors and drug adherence in the occurrence of stroke in patients with atrial fibrillation
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| Format: | Artículo científico |
| Sprache: | en |
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Centro de investigaciones y Publicaciones Farmacéuticas
2020
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| _version_ | 1876461221023055872 |
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| author | Maya El-Hajj |
| author_facet | Maya El-Hajj |
| contents | Evaluation of risk factors and drug adherence in the occurrence of stroke in patients with atrial fibrillation Maya El-Hajj Roula Ajrouche Salam Zein Samar Rachidi Sanaa Awada Amal Al-Hajje Medicina Case Stroke Obesity Lebanon Inpatients Background: Atrial fibrillation (AF) patients are at high risk of developing a stroke and anticoagulant medications are generally prescribed to prevent stroke in AF population.Objective: This study aims to evaluate stroke risk factors among hospitalized patients with AF and to assess the level of adherence to medications in AF patients and their relation with stroke.Methods: This is a case-control study conducted between June 1st, 2018 and December 31th, 2018 among AF patients admitted to seven tertiary Lebanese hospitals. Data were collected using a standardized questionnaire. Adherence to medications was assessed using the Lebanese Medication Adherence Scale-14. Odds ratios (OR) expressed the strength of association between the independent variables and the dependent variable and were estimated using unconditional logistic regression adjusted for confounding factors. P<0.05 determined statistical significance.Results: In total, 174 cases of AF patients were included with 87 cases and 87 controls. The risk of stroke among AF significantly increased with the presence of a history of hypertension, aOR 16.04 (95%CI, 2.27-113.37; p=0.005), history of coronary heart disease/myocardial infarction, and history of obesity. Anticoagulant medication significantly decreased the risk of stroke among AF patients, aOR 0.27 (95%CI, 0.07-0.98; P=0.047). High adherence to medications was significantly associated with a reduced risk of stroke, aOR 0.04 (95%CI, 0.01-0.23; p<0.001).Conclusions: Having a history of hypertension is one of the strongest risk factors for stroke among AF patients in Lebanon. While anticoagulant medication use was associated with a reduced risk for stroke, high adherence to medications is critical for stroke prevention. Public health interventions are needed to tackle low-adherence to medication and prevent stroke among AF patients. 2020 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69065537017 https://www.redalyc.org/journal/690/69065537017/ https://www.redalyc.org/journal/690/69065537017/html/ https://www.redalyc.org/journal/690/69065537017/69065537017.epub https://www.redalyc.org/journal/690/69065537017/movil 10.18549/PharmPract.2020.2.1860 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.2 Vol.18 |
| format | Artículo científico |
| id | redalyc_69065537017 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Centro de investigaciones y Publicaciones Farmacéuticas |
| spellingShingle | Evaluation of risk factors and drug adherence in the occurrence of stroke in patients with atrial fibrillation Maya El-Hajj Medicina Case Stroke Obesity Lebanon Inpatients Evaluation of risk factors and drug adherence in the occurrence of stroke in patients with atrial fibrillation Maya El-Hajj Roula Ajrouche Salam Zein Samar Rachidi Sanaa Awada Amal Al-Hajje Medicina Case Stroke Obesity Lebanon Inpatients Background: Atrial fibrillation (AF) patients are at high risk of developing a stroke and anticoagulant medications are generally prescribed to prevent stroke in AF population.Objective: This study aims to evaluate stroke risk factors among hospitalized patients with AF and to assess the level of adherence to medications in AF patients and their relation with stroke.Methods: This is a case-control study conducted between June 1st, 2018 and December 31th, 2018 among AF patients admitted to seven tertiary Lebanese hospitals. Data were collected using a standardized questionnaire. Adherence to medications was assessed using the Lebanese Medication Adherence Scale-14. Odds ratios (OR) expressed the strength of association between the independent variables and the dependent variable and were estimated using unconditional logistic regression adjusted for confounding factors. P<0.05 determined statistical significance.Results: In total, 174 cases of AF patients were included with 87 cases and 87 controls. The risk of stroke among AF significantly increased with the presence of a history of hypertension, aOR 16.04 (95%CI, 2.27-113.37; p=0.005), history of coronary heart disease/myocardial infarction, and history of obesity. Anticoagulant medication significantly decreased the risk of stroke among AF patients, aOR 0.27 (95%CI, 0.07-0.98; P=0.047). High adherence to medications was significantly associated with a reduced risk of stroke, aOR 0.04 (95%CI, 0.01-0.23; p<0.001).Conclusions: Having a history of hypertension is one of the strongest risk factors for stroke among AF patients in Lebanon. While anticoagulant medication use was associated with a reduced risk for stroke, high adherence to medications is critical for stroke prevention. Public health interventions are needed to tackle low-adherence to medication and prevent stroke among AF patients. 2020 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69065537017 https://www.redalyc.org/journal/690/69065537017/ https://www.redalyc.org/journal/690/69065537017/html/ https://www.redalyc.org/journal/690/69065537017/69065537017.epub https://www.redalyc.org/journal/690/69065537017/movil 10.18549/PharmPract.2020.2.1860 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.2 Vol.18 |
| title | Evaluation of risk factors and drug adherence in the occurrence of stroke in patients with atrial fibrillation |
| topic | Medicina Case Stroke Obesity Lebanon Inpatients |
| url | https://www.redalyc.org/articulo.oa?id=69065537017 https://www.redalyc.org/journal/690/69065537017/ https://www.redalyc.org/journal/690/69065537017/html/ https://www.redalyc.org/journal/690/69065537017/69065537017.epub https://www.redalyc.org/journal/690/69065537017/movil |