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| Format: | Artículo científico |
| Language: | en |
| Published: |
Hospital San Pedro
2024
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| Online Access: | https://www.redalyc.org/articulo.oa?id=692076381002 https://www.redalyc.org/journal/6920/692076381002/ https://www.redalyc.org/journal/6920/692076381002/html/ https://www.redalyc.org/journal/6920/692076381002/692076381002.epub https://www.redalyc.org/journal/6920/692076381002/movil https://doi.org/10.53986/ibjm.2024.0001 |
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Table of Contents:
- Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19 Mehmet Çelik Mehmet Reşat Ceylan İsmail Koyuncu Nevin Güler Dinçer Sevil Alkan Medicina 19 COVID Heme oxygenase related factor 2 Total oxidant status Introduction: Studies on nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels in COVID-19 patients are limited. This study aimed to investigate the relationship between some biomarkers of oxidant-antioxidant status with COVID-19 disease. Material and methods: The patients older than 18 years of age who tested positive for SARS CoV-2 PCR (polymerase chain reaction) with clinical symptoms and signs were included in this study. Total antioxidant status (TAS), total antioxidant status (TOS), oxidative stress index (OSI) and HO-1 and Nrf2 levels were analyzed from serum samples taken before and after treatment. Results: In this study, 16 patients followed up with the diagnosis of COVID-19 were included. 9 (56.3%) of the patients were female and 7 (43.8%) were male. The mean age was 33.75 ± 17.03 years. All patients were symptomatic and were hospitalized to be followed up. It was determined that Nrf2 and HO-1 values increased significantly after treatment. Moreover, there was a significant positive correlation between Nrf2 and TAS values and TAS increases significantly in parallel to an increase in Nrf2, and there was a significant but negative correlation between Nrf2 and TOS and OSI values, and thus an increase in Nrf2 led to a decrease in TOS and OSI values. There was a significant positive correlation between HO-1 and TAS, and TAS increased significantly, as HO-1 increased. Conclusions: The decrease in TOS and OSI and the increase in Nrf2 and HO-1 during the follow-up period in COVID-19 patients suggest that the body tries to prevent ROS-related oxidative stress via Nrf2 and HO-1 and that oxidative stress may have a key role in the pathophysiology of COVID-19. 2024 artículo científico 2695-5075 https://www.redalyc.org/articulo.oa?id=692076381002 https://www.redalyc.org/journal/6920/692076381002/ https://www.redalyc.org/journal/6920/692076381002/html/ https://www.redalyc.org/journal/6920/692076381002/692076381002.epub https://www.redalyc.org/journal/6920/692076381002/movil https://doi.org/10.53986/ibjm.2024.0001 en http://www.redalyc.org/revista.oa?id=6920 Iberoamerican Journal of Medicine application/pdf Hospital San Pedro Iberoamerican Journal of Medicine (España) Num.1 Vol.6