Analysis of mdr1-1D mutation of MDR1 gene in the “Cimarron Uruguayo” dog
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad de Córdoba
2013
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| _version_ | 1876435156422623232 |
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| author | Rosa Gagliardi B |
| author_facet | Rosa Gagliardi B |
| contents | Analysis of mdr1-1D mutation of MDR1 gene in the “Cimarron Uruguayo” dog Rosa Gagliardi B Cristina García G Silvia Llambí D María Arruga L Veterinaria Dogs mutations pharmacogenetics (Source:CAB) Objective. The aim of this paper is to analyze the frequency of the mdr1-1D mutation of the MDR1 gene in a dog sample of the Uruguayan Cimarron breed with the objective of increasing the knowledge of this breed’s genome. Materials and methods. Thirty-six animals of this breed were analyzed. The MDR1 gene region, which includes the location where the mutation would be present, was amplified by PCR. Results. The mutation was not detected in any of the analyzed Uruguayan Cimarron. Conclusions. The lack of described ivermectin intoxication cases in veterinary clinic in this breed is explained by the lack of the mutation object of this study. The sequence studied in Cimarron dogs is kept compared to other breeds, except Collies and related breeds (Border Collie, Bearded Collie, Old English sheepdog). 2013 artículo científico 0122-0268 https://www.redalyc.org/articulo.oa?id=69328078008 en http://www.redalyc.org/revista.oa?id=693 Revista MVZ Córdoba application/pdf Universidad de Córdoba Revista MVZ Córdoba (Colombia) Num.2 Vol.18 |
| format | Artículo científico |
| id | redalyc_69328078008 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Universidad de Córdoba |
| spellingShingle | Analysis of mdr1-1D mutation of MDR1 gene in the “Cimarron Uruguayo” dog Rosa Gagliardi B Veterinaria Dogs mutations pharmacogenetics (Source:CAB) Analysis of mdr1-1D mutation of MDR1 gene in the “Cimarron Uruguayo” dog Rosa Gagliardi B Cristina García G Silvia Llambí D María Arruga L Veterinaria Dogs mutations pharmacogenetics (Source:CAB) Objective. The aim of this paper is to analyze the frequency of the mdr1-1D mutation of the MDR1 gene in a dog sample of the Uruguayan Cimarron breed with the objective of increasing the knowledge of this breed’s genome. Materials and methods. Thirty-six animals of this breed were analyzed. The MDR1 gene region, which includes the location where the mutation would be present, was amplified by PCR. Results. The mutation was not detected in any of the analyzed Uruguayan Cimarron. Conclusions. The lack of described ivermectin intoxication cases in veterinary clinic in this breed is explained by the lack of the mutation object of this study. The sequence studied in Cimarron dogs is kept compared to other breeds, except Collies and related breeds (Border Collie, Bearded Collie, Old English sheepdog). 2013 artículo científico 0122-0268 https://www.redalyc.org/articulo.oa?id=69328078008 en http://www.redalyc.org/revista.oa?id=693 Revista MVZ Córdoba application/pdf Universidad de Córdoba Revista MVZ Córdoba (Colombia) Num.2 Vol.18 |
| title | Analysis of mdr1-1D mutation of MDR1 gene in the “Cimarron Uruguayo” dog |
| topic | Veterinaria Dogs mutations pharmacogenetics (Source:CAB) |
| url | https://www.redalyc.org/articulo.oa?id=69328078008 |