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| Format: | Artículo científico |
| Language: | en |
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Universidad de Córdoba
2014
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| Online Access: | https://www.redalyc.org/articulo.oa?id=69332509010 |
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Table of Contents:
- Analgesic effect and side effects of celecoxib and meloxicam in canine hip osteoarthritis Víctor Molina D David Álzate V Jhon Ruíz B Manuela Urrea A Juan Tobón J Veterinaria Dog pain NSAIDS pharmacology ( Source: Mesh ) Objective . To evaluate the pharmacological, clinical and toxicological effects of celecoxib and meloxicam for analgesia for 30 days in dogs with hip osteoarthritis. Materials and methods . Twenty-four patients were evaluated, 75% were females with an average age of 7.16 ± 2.06 years and twenty five percent were males with an average age of 7.83 ± 2.22 years. All patients had hip osteoarthritis and they were randomized into two groups; one group received oral celecoxib 5 mg/kg every 12 hours during one month and the second group received oral meloxicam 0.2 mg/kg every 24 hours during 1 month. The patients were evaluated for analgesia, and hematological, renal, liver, and coagulation tests on days 0, 10 th and 30 th after treatment initiation, and a gastric endoscopy on day 30. Statistical analysis was performed using a HSD Tukey test and c 2 with a 5% level of statistical significance. Results. Both drugs reduced articular pain according to the Melbourne scale during the 30 days of treatment (p≤0.05). Hematological, renal, hepatic and coagulation tests were normal in both treatment groups. All patients presented chronic gastritis on endoscopy on day 30 th . Conclusions. Both drugs decreased pain at day 30 th without causing alterations in hematological, renal, hepatic or coagulation tests after 30 days of treatment. However, both drugs induced chronic gastritis. 2014 artículo científico 0122-0268 https://www.redalyc.org/articulo.oa?id=69332509010 en http://www.redalyc.org/revista.oa?id=693 Revista MVZ Córdoba application/pdf Universidad de Córdoba Revista MVZ Córdoba (Colombia) Num.3 Vol.19