Endothelin-1 expression in pulmonary hypertensive chickens by hypoxia
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad de Córdoba
2017
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| _version_ | 1876482222769307648 |
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| author | Luis Carlos Monroy G |
| author_facet | Luis Carlos Monroy G |
| contents | Endothelin-1 expression in pulmonary hypertensive chickens by hypoxia Luis Carlos Monroy G Aureliano Hernández V Veterinaria Arterioles Arterioles endothelin endothelin morphometry Objective. To determine the effect of hypobaric hypoxia exposition in pulmonary arterioles expression of endothelin-1 (ET-1). Materials and methods. Two groups of commercial broiler chickens were used: one of them were raised at 2638 (hypobaric hypoxia) and the other one at 300 m (relative normoxia) above sea level. Incidence of pulmonary hypertension (PH) was evaluated by calculating the cardiac mass index values and ET-1 protein expression was established in pulmonary arterioles by immunohistochemistry and morphometry. Results. ET-1 expression was higher in arterioles of animals exposed to hypoxia as compared to the low altitude exposed broilers (p<0.01). Arterioles from pulmonary hypertensive chickens (PHC) showed ET-1 higher expression than arterioles from healthy chickens (non-hypertensive, NHC) at low altitude, those exposed to hypobaric hypoxia (p<0.01). 53% of chickens subjected to altitude conditions developed pulmonary hypertension. Under normoxia, no chickens developed that pathology. Conclusions. Quantitative characteristics and sites of ET-1 expression in the lungs are important in the understanding of PH pathogenesis in broilers and the adapting mechanisms to hypobaric hypoxia, as to design new pharmacological approaches. This is a first approach which accounts for the abovementioned features in broilers subjected to natural conditions of normoxia and hypobaric hypoxia. 2017 artículo científico 0122-0268 https://www.redalyc.org/articulo.oa?id=69353272012 https://www.redalyc.org/journal/693/69353272012/ https://www.redalyc.org/journal/693/69353272012/html/ https://www.redalyc.org/journal/693/69353272012/69353272012.epub https://www.redalyc.org/journal/693/69353272012/movil en http://www.redalyc.org/revista.oa?id=693 Revista MVZ Córdoba application/pdf Universidad de Córdoba Revista MVZ Córdoba (Colombia) Num.2 Vol.22 |
| format | Artículo científico |
| id | redalyc_69353272012 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Universidad de Córdoba |
| spellingShingle | Endothelin-1 expression in pulmonary hypertensive chickens by hypoxia Luis Carlos Monroy G Veterinaria Arterioles Arterioles endothelin endothelin morphometry Endothelin-1 expression in pulmonary hypertensive chickens by hypoxia Luis Carlos Monroy G Aureliano Hernández V Veterinaria Arterioles Arterioles endothelin endothelin morphometry Objective. To determine the effect of hypobaric hypoxia exposition in pulmonary arterioles expression of endothelin-1 (ET-1). Materials and methods. Two groups of commercial broiler chickens were used: one of them were raised at 2638 (hypobaric hypoxia) and the other one at 300 m (relative normoxia) above sea level. Incidence of pulmonary hypertension (PH) was evaluated by calculating the cardiac mass index values and ET-1 protein expression was established in pulmonary arterioles by immunohistochemistry and morphometry. Results. ET-1 expression was higher in arterioles of animals exposed to hypoxia as compared to the low altitude exposed broilers (p<0.01). Arterioles from pulmonary hypertensive chickens (PHC) showed ET-1 higher expression than arterioles from healthy chickens (non-hypertensive, NHC) at low altitude, those exposed to hypobaric hypoxia (p<0.01). 53% of chickens subjected to altitude conditions developed pulmonary hypertension. Under normoxia, no chickens developed that pathology. Conclusions. Quantitative characteristics and sites of ET-1 expression in the lungs are important in the understanding of PH pathogenesis in broilers and the adapting mechanisms to hypobaric hypoxia, as to design new pharmacological approaches. This is a first approach which accounts for the abovementioned features in broilers subjected to natural conditions of normoxia and hypobaric hypoxia. 2017 artículo científico 0122-0268 https://www.redalyc.org/articulo.oa?id=69353272012 https://www.redalyc.org/journal/693/69353272012/ https://www.redalyc.org/journal/693/69353272012/html/ https://www.redalyc.org/journal/693/69353272012/69353272012.epub https://www.redalyc.org/journal/693/69353272012/movil en http://www.redalyc.org/revista.oa?id=693 Revista MVZ Córdoba application/pdf Universidad de Córdoba Revista MVZ Córdoba (Colombia) Num.2 Vol.22 |
| title | Endothelin-1 expression in pulmonary hypertensive chickens by hypoxia |
| topic | Veterinaria Arterioles Arterioles endothelin endothelin morphometry |
| url | https://www.redalyc.org/articulo.oa?id=69353272012 https://www.redalyc.org/journal/693/69353272012/ https://www.redalyc.org/journal/693/69353272012/html/ https://www.redalyc.org/journal/693/69353272012/69353272012.epub https://www.redalyc.org/journal/693/69353272012/movil |