Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms
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| Format: | Artículo científico |
| Language: | en |
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Vilniaus Universitetas
2021
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| author | Adelė Butėnaitė* |
| author_facet | Adelė Butėnaitė* |
| contents | Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms Adelė Butėnaitė* Robertas Strumila Aistė Lengvenytė Indrė Kotryna Pakutkaitė Aušra Morkūnienė Aušra Matulevičienė Edgaras Dlugauskas Algirdas Utkus Medicina anxiety huntingtin depression hopelessness Huntington’s disease Background: In Huntington’s disease psychiatric symptoms may manifest prior to motor dysfunction. Such symptoms negatively impact people’s quality of life and can worsen the course of the primary disease. The aim of the present study was to assess and compare depression, anxiety and hopelessness rates in individuals with and without an abnormal expansion of CAG repeats in the huntingtin (HTT) gene and healthy controls. Materials and methods: Study involved 31 individuals referred for genetic testing for Huntington’s disease and a control group of 41. Depressive and anxiety symptoms were assessed using Beck Hopelessness Scale (BHS) and Hospital Anxiety and Depression Scale (HADS). Results between groups were compared using the Mann–Whitney U test. Two-sided Bonferroni corrected p-value was set at ≤0.017. Results: Individuals with HTT gene mutation (“gene mutation positive”, GMP) (N=20) scored higher on the HADS depression subscale (5.90 ± 4.52 vs 1.36 ± 1.91; p ≤ 0.017) than those without HTT gene mutation (“gene mutation negative”, GMN) (N=11). GMP and control groups scored higher than the GMN group on the BHS (5.65 ± 3.91 vs 2.09 ± 1.64 and 5.27 ± 4.11 vs 2.09 ± 1.64, respectively; p ≤ 0.017). No differences in anxiety levels were found. Conclusions: Depressive symptoms and hopelessness were more prevalent in individuals with HTT gene mutation than in individuals who were tested but had no said mutation. Such results emphasise the importance of timely diagnosis and treatment of psychiatric comorbidities in individuals affected by Huntington’s disease. 2021 artículo científico 2029-4174 https://www.redalyc.org/articulo.oa?id=694072807003 https://www.redalyc.org/journal/6940/694072807003/ https://www.redalyc.org/journal/6940/694072807003/html/ https://www.redalyc.org/journal/6940/694072807003/694072807003.epub https://www.redalyc.org/journal/6940/694072807003/movil https://doi.org/10.15388/Amed.2020.28.1.4 en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.1 Vol.28 |
| format | Artículo científico |
| id | redalyc_694072807003 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Vilniaus Universitetas |
| spellingShingle | Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms Adelė Butėnaitė* Medicina anxiety huntingtin depression hopelessness Huntington’s disease Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms Adelė Butėnaitė* Robertas Strumila Aistė Lengvenytė Indrė Kotryna Pakutkaitė Aušra Morkūnienė Aušra Matulevičienė Edgaras Dlugauskas Algirdas Utkus Medicina anxiety huntingtin depression hopelessness Huntington’s disease Background: In Huntington’s disease psychiatric symptoms may manifest prior to motor dysfunction. Such symptoms negatively impact people’s quality of life and can worsen the course of the primary disease. The aim of the present study was to assess and compare depression, anxiety and hopelessness rates in individuals with and without an abnormal expansion of CAG repeats in the huntingtin (HTT) gene and healthy controls. Materials and methods: Study involved 31 individuals referred for genetic testing for Huntington’s disease and a control group of 41. Depressive and anxiety symptoms were assessed using Beck Hopelessness Scale (BHS) and Hospital Anxiety and Depression Scale (HADS). Results between groups were compared using the Mann–Whitney U test. Two-sided Bonferroni corrected p-value was set at ≤0.017. Results: Individuals with HTT gene mutation (“gene mutation positive”, GMP) (N=20) scored higher on the HADS depression subscale (5.90 ± 4.52 vs 1.36 ± 1.91; p ≤ 0.017) than those without HTT gene mutation (“gene mutation negative”, GMN) (N=11). GMP and control groups scored higher than the GMN group on the BHS (5.65 ± 3.91 vs 2.09 ± 1.64 and 5.27 ± 4.11 vs 2.09 ± 1.64, respectively; p ≤ 0.017). No differences in anxiety levels were found. Conclusions: Depressive symptoms and hopelessness were more prevalent in individuals with HTT gene mutation than in individuals who were tested but had no said mutation. Such results emphasise the importance of timely diagnosis and treatment of psychiatric comorbidities in individuals affected by Huntington’s disease. 2021 artículo científico 2029-4174 https://www.redalyc.org/articulo.oa?id=694072807003 https://www.redalyc.org/journal/6940/694072807003/ https://www.redalyc.org/journal/6940/694072807003/html/ https://www.redalyc.org/journal/6940/694072807003/694072807003.epub https://www.redalyc.org/journal/6940/694072807003/movil https://doi.org/10.15388/Amed.2020.28.1.4 en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.1 Vol.28 |
| title | Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms |
| topic | Medicina anxiety huntingtin depression hopelessness Huntington’s disease |
| url | https://www.redalyc.org/articulo.oa?id=694072807003 https://www.redalyc.org/journal/6940/694072807003/ https://www.redalyc.org/journal/6940/694072807003/html/ https://www.redalyc.org/journal/6940/694072807003/694072807003.epub https://www.redalyc.org/journal/6940/694072807003/movil https://doi.org/10.15388/Amed.2020.28.1.4 |