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| Format: | Artículo científico |
| Sprache: | en |
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Vilniaus Universitetas
2020
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=694073948006 https://www.redalyc.org/journal/6940/694073948006/ https://www.redalyc.org/journal/6940/694073948006/html/ https://www.redalyc.org/journal/6940/694073948006/694073948006.epub https://www.redalyc.org/journal/6940/694073948006/movil |
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Inhaltsangabe:
- Improvement in childhood cancer survival in Lithuania over three decades Jelena Rascon Giedrė Smailytė Medicina survival Lithuania Childhood cancer Population-based EUROCARE-5 studies demonstrated that childhood cancer survival rates in Lithuania were 10–20% lower than the European mean. We aimed to analyse the change in the outcome of treatment of paediatric malignancies in Lithuania over 30 years. Methods. A single-centre retrospective analysis of children below 18 years of age treated for cancer at Vilnius University Hospital Santa- ros Klinikos between 1982 and 2011 was carried out. The minimal re- quirement of 5-year follow-up after diagnosis was specified for survival estimation. The vital status was assessed using data from the popula- tion-based Lithuanian Cancer Registry. To evaluate changes over time, the entire cohort was split into three groups according to the time of diagnosis: 1982–1991, 1992–2001, and 2002–2011. Results. A total of 1268 children met the inclusion criteria. The shortest median follow-up was 8.9 (IQR 6.4–11.5) years for patients treated in the third decade. The 5-year overall survival of the entire co- hort increased from 37.3% (95% CI 30.2–44.3) in 1982–1991 to 70.7% (95% CI 66.4–74.1) in 2002–2011 (p < 0.0001). The same trend was ev- ident when calculated separately for leukaemia (p < 0.0001), lymphoma (p < 0.0005), and solid tumours (p < 0.004). The percentage of cure rose from zero in the early years of the period analysed to 80% in 2010 and 2011. The improvement in the treatment outcome was attributable to the reduction of treatment-related mortality from 45.8% in 1982–1991 to 12.4% in 2002–2011 and disease recurrence from 30.4% to 19.6% for the same periods, respectively. Conclusions. Significant progress in the cure rate of children treat- ed for cancer at our institution was observed over 30 years. Collabora- tive national and international clinical and research efforts are crucial to ensure further advances in care and cure. 2020 artículo científico 2029-4174 https://www.redalyc.org/articulo.oa?id=694073948006 https://www.redalyc.org/journal/6940/694073948006/ https://www.redalyc.org/journal/6940/694073948006/html/ https://www.redalyc.org/journal/6940/694073948006/694073948006.epub https://www.redalyc.org/journal/6940/694073948006/movil en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.1 Vol.27