A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report
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| Natura: | Artículo científico |
| Lingua: | en |
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Vilniaus Universitetas
2016
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| _version_ | 1876427571995869184 |
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| author | Violeta Labžentytė |
| author_facet | Violeta Labžentytė |
| contents | A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report Violeta Labžentytė Silvija Zemnickienė Edvardas Danila Virginija Šileikienė Rolandas Zablockis Vygantas Gruslys Medicina Bronchiectasis computed tomography bone marrow transplantation chronic graft versus host disease Introduction. We report a case of a patient with acute myeloid leukaemia whose treatment with bone marrow transplantation (BMT) was followed by chronic graft versus host disease (GVHD) with lung involvement and bronchiectasis. This report illustrates an unusual course of a fast progression of the bronchiectasis due to BMT. Case description. A 33-year-old female was diagnosed with acute myeloid leukaemia. An allogeneic BMT was performed. One month after the transplantation, acute GVHD with skin involvement occurred. Treatment with prednisolone and mycophenolate mofetil (MMF) has been started. Nine months later, the patient was examined by a pulmonologist due to progressive dyspnoea. A pulmonary computed tomography (CT) scan showed normal parenchyma of the lungs and no changes to the bronchi. A CT scan performed 7 months later revealed bronchiectasis for the first time. No clinical response was associated with the treatment and the patient’s respiratory status progressively deteriorated. During the final hospitalization, a CT scan performed 1 year later revealed huge cystic bronchiectasis in both lungs. Despite the prophylaxis and treatment of GVHD and aggressive antimicrobial therapy, the patient died one year after the diagnosis of bronchiectasis. Conclusions. This case demonstrates that a fast and fatal course of bronchiectasis, that occurs after BMT, should always be considered as a possible manifestation of chronic graft versus host disease (cGVHD) following allogeneic BMT. 2016 otro 2029-4174 https://www.redalyc.org/articulo.oa?id=694073987009 en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.1 Vol.23 |
| format | Artículo científico |
| id | redalyc_694073987009 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Vilniaus Universitetas |
| spellingShingle | A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report Violeta Labžentytė Medicina Bronchiectasis computed tomography bone marrow transplantation chronic graft versus host disease A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report Violeta Labžentytė Silvija Zemnickienė Edvardas Danila Virginija Šileikienė Rolandas Zablockis Vygantas Gruslys Medicina Bronchiectasis computed tomography bone marrow transplantation chronic graft versus host disease Introduction. We report a case of a patient with acute myeloid leukaemia whose treatment with bone marrow transplantation (BMT) was followed by chronic graft versus host disease (GVHD) with lung involvement and bronchiectasis. This report illustrates an unusual course of a fast progression of the bronchiectasis due to BMT. Case description. A 33-year-old female was diagnosed with acute myeloid leukaemia. An allogeneic BMT was performed. One month after the transplantation, acute GVHD with skin involvement occurred. Treatment with prednisolone and mycophenolate mofetil (MMF) has been started. Nine months later, the patient was examined by a pulmonologist due to progressive dyspnoea. A pulmonary computed tomography (CT) scan showed normal parenchyma of the lungs and no changes to the bronchi. A CT scan performed 7 months later revealed bronchiectasis for the first time. No clinical response was associated with the treatment and the patient’s respiratory status progressively deteriorated. During the final hospitalization, a CT scan performed 1 year later revealed huge cystic bronchiectasis in both lungs. Despite the prophylaxis and treatment of GVHD and aggressive antimicrobial therapy, the patient died one year after the diagnosis of bronchiectasis. Conclusions. This case demonstrates that a fast and fatal course of bronchiectasis, that occurs after BMT, should always be considered as a possible manifestation of chronic graft versus host disease (cGVHD) following allogeneic BMT. 2016 otro 2029-4174 https://www.redalyc.org/articulo.oa?id=694073987009 en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.1 Vol.23 |
| title | A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report |
| topic | Medicina Bronchiectasis computed tomography bone marrow transplantation chronic graft versus host disease |
| url | https://www.redalyc.org/articulo.oa?id=694073987009 |