Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia
Fuente:
Redalyc
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Vilniaus Universitetas
2014
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1876481262219165696 |
|---|---|
| author | Vincas Urbonas |
| author_facet | Vincas Urbonas |
| contents | Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia Vincas Urbonas Audronė Eidukaitė Medicina leukemia bacteremia interleukin Procalcitonin febrile neutropenia Background. Currently available biomarkers are not specific and sensitive enough for early detection of bacterial infection in patients with cancer who have febrile neutropenia. The objective of this study was to assess diagnostic accuracy of interleukin-6 (IL-6), interleukin-8 (IL-8) and procalcitonin (PCT) in the identification of Gram-negative bacteremia at the beginning of a febrile episode in pediatric oncology patients with acute lymphoblastic leukemia (ALL). Methods. A total of 40 episodes of febrile neutropenia in 27 childhood cancer patients were enrolled in this study. Serum samples were collected at presentation after confirmation of febrile neutropenia and analyzed according to the recommendations of manufacturers. Patients were classified into Gram-negative bacteremia (GNB) and fever of unknown origin (FUO) groups. Results. The median concentration of IL-6, IL-8 and PCT were higher in the GNB group compared to the FUO group (65.4 vs. 409.0 pg/ml, P = 0.0025; 166.0 vs. 883.0 pg/ml, P = 0.0002; 0.27 vs. 0.44 ng/ml, P = 0.0169, respectively). The areas under the curves (AUCs) for both IL-6 and IL-8 were 0.94 and 0.93, respectively, indicating that these cytokines discriminated patients with Gram-negative bacteremia with excellent accuracy, whereas PCT had lower diagnostic accuracy (AUC = 0.76). Conclusions. IL-6 and IL-8 evaluation might be used as an additional diagnostic tool for the prediction of Gram-negative bacteremia in pediatric patients with ALL during febrile neutropenia episodes.. 2014 artículo científico 2029-4174 https://www.redalyc.org/articulo.oa?id=694074052006 en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.4 Vol.21 |
| format | Artículo científico |
| id | redalyc_694074052006 |
| institution | Redalyc |
| language | en |
| publishDate | 2014 |
| publisher | Vilniaus Universitetas |
| spellingShingle | Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia Vincas Urbonas Medicina leukemia bacteremia interleukin Procalcitonin febrile neutropenia Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia Vincas Urbonas Audronė Eidukaitė Medicina leukemia bacteremia interleukin Procalcitonin febrile neutropenia Background. Currently available biomarkers are not specific and sensitive enough for early detection of bacterial infection in patients with cancer who have febrile neutropenia. The objective of this study was to assess diagnostic accuracy of interleukin-6 (IL-6), interleukin-8 (IL-8) and procalcitonin (PCT) in the identification of Gram-negative bacteremia at the beginning of a febrile episode in pediatric oncology patients with acute lymphoblastic leukemia (ALL). Methods. A total of 40 episodes of febrile neutropenia in 27 childhood cancer patients were enrolled in this study. Serum samples were collected at presentation after confirmation of febrile neutropenia and analyzed according to the recommendations of manufacturers. Patients were classified into Gram-negative bacteremia (GNB) and fever of unknown origin (FUO) groups. Results. The median concentration of IL-6, IL-8 and PCT were higher in the GNB group compared to the FUO group (65.4 vs. 409.0 pg/ml, P = 0.0025; 166.0 vs. 883.0 pg/ml, P = 0.0002; 0.27 vs. 0.44 ng/ml, P = 0.0169, respectively). The areas under the curves (AUCs) for both IL-6 and IL-8 were 0.94 and 0.93, respectively, indicating that these cytokines discriminated patients with Gram-negative bacteremia with excellent accuracy, whereas PCT had lower diagnostic accuracy (AUC = 0.76). Conclusions. IL-6 and IL-8 evaluation might be used as an additional diagnostic tool for the prediction of Gram-negative bacteremia in pediatric patients with ALL during febrile neutropenia episodes.. 2014 artículo científico 2029-4174 https://www.redalyc.org/articulo.oa?id=694074052006 en http://www.redalyc.org/revista.oa?id=6940 Acta medica Lituanica application/pdf Vilniaus Universitetas Acta medica Lituanica (Lituania) Num.4 Vol.21 |
| title | Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia |
| topic | Medicina leukemia bacteremia interleukin Procalcitonin febrile neutropenia |
| url | https://www.redalyc.org/articulo.oa?id=694074052006 |