Relation of frailty and polypharmacy on cognitive impairment in Chilean Older Adults
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad Autónoma de Bucaramanga
2025
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| _version_ | 1876432252928262144 |
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| author | Diego Arauna |
| author_facet | Diego Arauna |
| contents | Relation of frailty and polypharmacy on cognitive impairment in Chilean Older Adults Diego Arauna Simón Navarrete Nacim Molina Lemuel Reyes Juan Pablo Rojas Eduardo Fuentes Iván Palomo Medicina Aged Aging Cross Frailty Geriatrics Introduction . The accelerated aging of the population increases the risk of the appearance of geriatric complications, such as cognitive damage. This damage has been related to frailty syndrome and polypharmacy in European cohorts, however, its relationship has not been fully clarified in Latin- American older people. This study aimed to evaluate the relationship between cognitive impairment, polypharmacy, and the frailty syndrome in Chilean older adults. Methodology . The investigation was designed as a cross-sectional study. The total of participants was 1,205 older adults, 65 years old and older. The presence or frailty was determined according to Fried Criteria. Polypharmacy status was evaluated employing a validated questionnaire conducted by a trained interviewer. The cognitive state was determined by the Mini-Mental State Examination. Results . The prevalence of cognitive impairment in the studied tranversal was 19%. Older adults with cognitive impairment had a higher frailty score (2.39±1.45, p<0.001), a higher prevalence of frailty, and a higher prevalence of polypharmacy (45.6%, p=0.0016) compared to older adults with normal cognition. The frailty criteria weight loss (OR: 1.88, CI= 1.22-2.90, p=0.004), exhaustion (OR: 2.66, CI= 1.89-3.76, p<0.001), slowness (OR: 2.10, p<0.001), and low physical activity (OR: 1.59, p=0.009) were associated with cognitive impairment, however, the weakness criteria did not present a significant association (OR: 1.29, CI=0.94-1.80, p=0.119). Discussion . Cognitive impairment was present in 19% of aged and was related to aging, lower educational level, living alone, frailty, and polypharmacy. Conclusions . Interventional strategies targeting frailty and excess consumption of medications may be a promising approach to prevent cognitive impairment. 2025 artículo científico 0123-7047 https://www.redalyc.org/articulo.oa?id=71983381002 https://www.redalyc.org/journal/719/71983381002/ https://www.redalyc.org/journal/719/71983381002/html/ https://www.redalyc.org/journal/719/71983381002/71983381002.epub https://www.redalyc.org/journal/719/71983381002/movil 10.29375/01237047.5107 en http://www.redalyc.org/revista.oa?id=719 MedUNAB application/pdf Universidad Autónoma de Bucaramanga MedUNAB (Colombia) Num.2 Vol.28 |
| format | Artículo científico |
| id | redalyc_71983381002 |
| institution | Redalyc |
| language | en |
| publishDate | 2025 |
| publisher | Universidad Autónoma de Bucaramanga |
| spellingShingle | Relation of frailty and polypharmacy on cognitive impairment in Chilean Older Adults Diego Arauna Medicina Aged Aging Cross Frailty Geriatrics Relation of frailty and polypharmacy on cognitive impairment in Chilean Older Adults Diego Arauna Simón Navarrete Nacim Molina Lemuel Reyes Juan Pablo Rojas Eduardo Fuentes Iván Palomo Medicina Aged Aging Cross Frailty Geriatrics Introduction . The accelerated aging of the population increases the risk of the appearance of geriatric complications, such as cognitive damage. This damage has been related to frailty syndrome and polypharmacy in European cohorts, however, its relationship has not been fully clarified in Latin- American older people. This study aimed to evaluate the relationship between cognitive impairment, polypharmacy, and the frailty syndrome in Chilean older adults. Methodology . The investigation was designed as a cross-sectional study. The total of participants was 1,205 older adults, 65 years old and older. The presence or frailty was determined according to Fried Criteria. Polypharmacy status was evaluated employing a validated questionnaire conducted by a trained interviewer. The cognitive state was determined by the Mini-Mental State Examination. Results . The prevalence of cognitive impairment in the studied tranversal was 19%. Older adults with cognitive impairment had a higher frailty score (2.39±1.45, p<0.001), a higher prevalence of frailty, and a higher prevalence of polypharmacy (45.6%, p=0.0016) compared to older adults with normal cognition. The frailty criteria weight loss (OR: 1.88, CI= 1.22-2.90, p=0.004), exhaustion (OR: 2.66, CI= 1.89-3.76, p<0.001), slowness (OR: 2.10, p<0.001), and low physical activity (OR: 1.59, p=0.009) were associated with cognitive impairment, however, the weakness criteria did not present a significant association (OR: 1.29, CI=0.94-1.80, p=0.119). Discussion . Cognitive impairment was present in 19% of aged and was related to aging, lower educational level, living alone, frailty, and polypharmacy. Conclusions . Interventional strategies targeting frailty and excess consumption of medications may be a promising approach to prevent cognitive impairment. 2025 artículo científico 0123-7047 https://www.redalyc.org/articulo.oa?id=71983381002 https://www.redalyc.org/journal/719/71983381002/ https://www.redalyc.org/journal/719/71983381002/html/ https://www.redalyc.org/journal/719/71983381002/71983381002.epub https://www.redalyc.org/journal/719/71983381002/movil 10.29375/01237047.5107 en http://www.redalyc.org/revista.oa?id=719 MedUNAB application/pdf Universidad Autónoma de Bucaramanga MedUNAB (Colombia) Num.2 Vol.28 |
| title | Relation of frailty and polypharmacy on cognitive impairment in Chilean Older Adults |
| topic | Medicina Aged Aging Cross Frailty Geriatrics |
| url | https://www.redalyc.org/articulo.oa?id=71983381002 https://www.redalyc.org/journal/719/71983381002/ https://www.redalyc.org/journal/719/71983381002/html/ https://www.redalyc.org/journal/719/71983381002/71983381002.epub https://www.redalyc.org/journal/719/71983381002/movil |