Genotoxic and anti-proliferative effects of aminoguanidine on gammairradiated MCF-7 breast cancer cells.
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| Format: | Artículo científico |
| Sprache: | en |
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Sociedade Brasileira de Proteção Radiológica - SBPR
2019
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| _version_ | 1876465812366163968 |
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| author | Danielle Cabral Fonseca |
| author_facet | Danielle Cabral Fonseca |
| contents | Genotoxic and anti-proliferative effects of aminoguanidine on gammairradiated MCF-7 breast cancer cells. Danielle Cabral Fonseca Ivette Zegarra Ocampo Daniel Perez Vieira Biología radiation Nitric oxide breast cancer The intracellular production of nitric oxide is studied as a relevant phenomenon in exposure to ionizing radiation. There is evidence of local nitric oxide production in solid tumors. The study evaluated the effects of the administration of aminoguanidine, a selective inhibitor of an isoform of nitric oxide synthase on the frequency of genotoxic damage, loss of clonogenic potential and induction of cytotoxicity after exposure of human breast tumor (MCF7) cells to ionizing radiation in radiotherapeutic doses. Cells were treated with aminoguanidine (1 or 2 mM) and irradiated by gamma radiation at doses between 0.5 and 8Gy. In cultures treated with 1 mM, we observed increased cytotoxicity and genotoxicity, and reduction of the clonogenic potential of the colonies. Alternatively, 2 mM aminoguanidine produced the opposite effect, apparently protecting cultures from the effects of exposures. The experiments suggested that the administration of aminoguanidine may reduce the in vitro radiosensitivity of tumors due to the increase of the frequency of genotoxic damage. 2019 artículo científico 2319-0612 https://www.redalyc.org/articulo.oa?id=722280831004 en http://www.redalyc.org/revista.oa?id=7222 Brazilian Journal of Radiation Sciences application/pdf Sociedade Brasileira de Proteção Radiológica - SBPR Brazilian Journal of Radiation Sciences (Brasil) Num.1 Vol.7 |
| format | Artículo científico |
| id | redalyc_722280831004 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedade Brasileira de Proteção Radiológica - SBPR |
| spellingShingle | Genotoxic and anti-proliferative effects of aminoguanidine on gammairradiated MCF-7 breast cancer cells. Danielle Cabral Fonseca Biología radiation Nitric oxide breast cancer Genotoxic and anti-proliferative effects of aminoguanidine on gammairradiated MCF-7 breast cancer cells. Danielle Cabral Fonseca Ivette Zegarra Ocampo Daniel Perez Vieira Biología radiation Nitric oxide breast cancer The intracellular production of nitric oxide is studied as a relevant phenomenon in exposure to ionizing radiation. There is evidence of local nitric oxide production in solid tumors. The study evaluated the effects of the administration of aminoguanidine, a selective inhibitor of an isoform of nitric oxide synthase on the frequency of genotoxic damage, loss of clonogenic potential and induction of cytotoxicity after exposure of human breast tumor (MCF7) cells to ionizing radiation in radiotherapeutic doses. Cells were treated with aminoguanidine (1 or 2 mM) and irradiated by gamma radiation at doses between 0.5 and 8Gy. In cultures treated with 1 mM, we observed increased cytotoxicity and genotoxicity, and reduction of the clonogenic potential of the colonies. Alternatively, 2 mM aminoguanidine produced the opposite effect, apparently protecting cultures from the effects of exposures. The experiments suggested that the administration of aminoguanidine may reduce the in vitro radiosensitivity of tumors due to the increase of the frequency of genotoxic damage. 2019 artículo científico 2319-0612 https://www.redalyc.org/articulo.oa?id=722280831004 en http://www.redalyc.org/revista.oa?id=7222 Brazilian Journal of Radiation Sciences application/pdf Sociedade Brasileira de Proteção Radiológica - SBPR Brazilian Journal of Radiation Sciences (Brasil) Num.1 Vol.7 |
| title | Genotoxic and anti-proliferative effects of aminoguanidine on gammairradiated MCF-7 breast cancer cells. |
| topic | Biología radiation Nitric oxide breast cancer |
| url | https://www.redalyc.org/articulo.oa?id=722280831004 |