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| Format: | Artículo científico |
| Sprache: | en |
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Sociedade Brasileira de Proteção Radiológica - SBPR
2019
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| Online-Zugang: | https://www.redalyc.org/articulo.oa?id=722280831005 |
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Inhaltsangabe:
- Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation Daniel Perez Vieira Andrés Jimenez Galisteo Jr Heitor Franco de Andrade Jr Biología CXCL12 Nitric oxide hematopoiesis Reduction of nitric oxide (NO) production is related to increased survival in some models of infection and ionizing radiation (IR) exposure. The work used lethally irradiated (60Co, 8Gy) C57Bl6j mice, treated or not with aminoguanidine (AG), an inhibitor of an isoform of nitric oxide synthase (iNOS). Also tested iNOS-/- knockout mice and a distinct group treated intraperitoneally with synthetic CXCL12, a homing chemokine related to hematopoietic reconstitution after IR exposures. Aminoguanidine treatment lead to an overshoot of proliferation of hematopoietic CD34+ cells in bone marrows (day 2 after IR) and spleens (days 2 and 4 after IR) of irradiated mice, showing a compensative response of these organs against deleterious effects of radiation. CXCL12 mRNA production was increased on spleens of AG-treated mice at day 2 after IR, but not on other periods neither in bone marrows. CXCL12 administration did not alter CD34+ counts but seemed to keep circulating platelet counts in levels comparable to controls. Thus, CXCL12 and AG administration could help on bone marrow repopulation after critically exposed individuals. 2019 artículo científico 2319-0612 https://www.redalyc.org/articulo.oa?id=722280831005 en http://www.redalyc.org/revista.oa?id=7222 Brazilian Journal of Radiation Sciences application/pdf Sociedade Brasileira de Proteção Radiológica - SBPR Brazilian Journal of Radiation Sciences (Brasil) Num.1 Vol.7