Semiquantitative evaluation of [99mTc]TRODAT-1 binding potential by two methods of SPECT image reconstruction
Fuente:
Redalyc
Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedade Brasileira de Proteção Radiológica - SBPR
2019
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1876445188669308928 |
|---|---|
| author | Melissa Furlaneto Lellis Leite |
| author_facet | Melissa Furlaneto Lellis Leite |
| contents | Semiquantitative evaluation of [99mTc]TRODAT-1 binding potential by two methods of SPECT image reconstruction Melissa Furlaneto Lellis Leite Marilia Alves dos Reis Cássio Miri Oliveira Mario Luiz Vieira Castiglioni Rodrigo Affonseca Bressan Biología OSEM [99mTc]TRODAT 1 SPECT Image Binding Potential Filtered Back Projection TRODAT-1 is a radiopharmaceutical derived from tropane and linked to tecnecium-99m ([99mTc] TRODAT-1) has been used in studies of dopamine transporter (DAT) in central nervous system. Associated with the SPECT technique of acquisition, is able to detect changes in neurological disorders like Parkinson´s disease, evaluating the binding potential (BP) of DAT. The aim of this study was to evaluate the influence of the image reconstruction methods, Filtered Back Projection (FBP) and iterative reconstruction (OSEM), in BP values at the striatal region in 30 healthy volunteers. Images were analyzed by visual inspection and semi-quantitative analysis. Regions of interest (ROI) were made over striatal areas on both sides. Nonparametric Wilcoxon statistical analysis was performed between the BP values from the FBP and OSEM methods. Our results showed that the reconstruction methods have a statistical significant BP values difference in the total striatum (Z = -2,2787 p = 0.005), right striatum (Z = -2,602 p = 0.009) and left striatum (Z= 2,746 p = 0.006). The effect size was calculated to see if there influence in this test: the "large effect size" for all measurements was observed (total striatum r= -0.51; right striatum r= -0.48; left striatum r= -0.50). FBP is the usual method of reconstruction for brain SPECT images, and our results showed influence of the OSEM method in BP. It is concluded that the method of image reconstruction adopted should be standardized to avoid incorrect evaluations of BP values using [ 99mTc]TRODAT-1. 2019 artículo científico 2319-0612 https://www.redalyc.org/articulo.oa?id=722280838077 en http://www.redalyc.org/revista.oa?id=7222 Brazilian Journal of Radiation Sciences application/pdf Sociedade Brasileira de Proteção Radiológica - SBPR Brazilian Journal of Radiation Sciences (Brasil) Num.2A Vol.7 |
| format | Artículo científico |
| id | redalyc_722280838077 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedade Brasileira de Proteção Radiológica - SBPR |
| spellingShingle | Semiquantitative evaluation of [99mTc]TRODAT-1 binding potential by two methods of SPECT image reconstruction Melissa Furlaneto Lellis Leite Biología OSEM [99mTc]TRODAT 1 SPECT Image Binding Potential Filtered Back Projection Semiquantitative evaluation of [99mTc]TRODAT-1 binding potential by two methods of SPECT image reconstruction Melissa Furlaneto Lellis Leite Marilia Alves dos Reis Cássio Miri Oliveira Mario Luiz Vieira Castiglioni Rodrigo Affonseca Bressan Biología OSEM [99mTc]TRODAT 1 SPECT Image Binding Potential Filtered Back Projection TRODAT-1 is a radiopharmaceutical derived from tropane and linked to tecnecium-99m ([99mTc] TRODAT-1) has been used in studies of dopamine transporter (DAT) in central nervous system. Associated with the SPECT technique of acquisition, is able to detect changes in neurological disorders like Parkinson´s disease, evaluating the binding potential (BP) of DAT. The aim of this study was to evaluate the influence of the image reconstruction methods, Filtered Back Projection (FBP) and iterative reconstruction (OSEM), in BP values at the striatal region in 30 healthy volunteers. Images were analyzed by visual inspection and semi-quantitative analysis. Regions of interest (ROI) were made over striatal areas on both sides. Nonparametric Wilcoxon statistical analysis was performed between the BP values from the FBP and OSEM methods. Our results showed that the reconstruction methods have a statistical significant BP values difference in the total striatum (Z = -2,2787 p = 0.005), right striatum (Z = -2,602 p = 0.009) and left striatum (Z= 2,746 p = 0.006). The effect size was calculated to see if there influence in this test: the "large effect size" for all measurements was observed (total striatum r= -0.51; right striatum r= -0.48; left striatum r= -0.50). FBP is the usual method of reconstruction for brain SPECT images, and our results showed influence of the OSEM method in BP. It is concluded that the method of image reconstruction adopted should be standardized to avoid incorrect evaluations of BP values using [ 99mTc]TRODAT-1. 2019 artículo científico 2319-0612 https://www.redalyc.org/articulo.oa?id=722280838077 en http://www.redalyc.org/revista.oa?id=7222 Brazilian Journal of Radiation Sciences application/pdf Sociedade Brasileira de Proteção Radiológica - SBPR Brazilian Journal of Radiation Sciences (Brasil) Num.2A Vol.7 |
| title | Semiquantitative evaluation of [99mTc]TRODAT-1 binding potential by two methods of SPECT image reconstruction |
| topic | Biología OSEM [99mTc]TRODAT 1 SPECT Image Binding Potential Filtered Back Projection |
| url | https://www.redalyc.org/articulo.oa?id=722280838077 |