Understanding the Geometric Language of Endothelial Cells Under Flow Condition
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| Format: | Artículo científico |
| Langue: | en |
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Universidad de Guadalajara
2011
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| _version_ | 1876447657419866112 |
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| author | Eric Avila Orozco |
| author_facet | Eric Avila Orozco |
| contents | Understanding the Geometric Language of Endothelial Cells Under Flow Condition Eric Avila Orozco Gerardo F. Rivera Silva Multidisciplinarias (Ciencias Sociales) Lamellipodia Cell Behaviour Vectorial Approach Geometric Analysis The use of in vitro cell culture studies has emerged as an important counterpart to in vivo investigations of vascular biology. Cells also depend under geometric and physical laws and tissue engineering has introduced new ways to understand cell behaviour. The study presented here focus on the responses of vascular endothelial cells to fluid frictional stress by using a mathematical and morphological analysis. A flow system was created where we submitted cultures of bovine aortic endothelial cells. We demonstrated that 80% of the endothelial cells under in vitro flow conditions align themselves toward the incoming flow. The shape of the cells submitted to the flow is dependant on the flow strength. We showed that the formation of lamellipodia is associated with a 103° angle and we propose that this angle could be the geometrical expression of Rac proteins. We used a new vectorial approach to show cell migration direction. We propose that endothelial cells under flow conditions adopt a shape to optimize their hydrodynamic capacities. With this study, we will advance in our understanding of the cellular geometrical comportment, an important feature of the endothelium artery coverage. 2011 artículo científico 1665-5745 https://www.redalyc.org/articulo.oa?id=73020063001 en http://www.redalyc.org/revista.oa?id=730 e-Gnosis application/pdf Universidad de Guadalajara e-Gnosis (México) Vol.9 |
| format | Artículo científico |
| id | redalyc_73020063001 |
| institution | Redalyc |
| language | en |
| publishDate | 2011 |
| publisher | Universidad de Guadalajara |
| spellingShingle | Understanding the Geometric Language of Endothelial Cells Under Flow Condition Eric Avila Orozco Multidisciplinarias (Ciencias Sociales) Lamellipodia Cell Behaviour Vectorial Approach Geometric Analysis Understanding the Geometric Language of Endothelial Cells Under Flow Condition Eric Avila Orozco Gerardo F. Rivera Silva Multidisciplinarias (Ciencias Sociales) Lamellipodia Cell Behaviour Vectorial Approach Geometric Analysis The use of in vitro cell culture studies has emerged as an important counterpart to in vivo investigations of vascular biology. Cells also depend under geometric and physical laws and tissue engineering has introduced new ways to understand cell behaviour. The study presented here focus on the responses of vascular endothelial cells to fluid frictional stress by using a mathematical and morphological analysis. A flow system was created where we submitted cultures of bovine aortic endothelial cells. We demonstrated that 80% of the endothelial cells under in vitro flow conditions align themselves toward the incoming flow. The shape of the cells submitted to the flow is dependant on the flow strength. We showed that the formation of lamellipodia is associated with a 103° angle and we propose that this angle could be the geometrical expression of Rac proteins. We used a new vectorial approach to show cell migration direction. We propose that endothelial cells under flow conditions adopt a shape to optimize their hydrodynamic capacities. With this study, we will advance in our understanding of the cellular geometrical comportment, an important feature of the endothelium artery coverage. 2011 artículo científico 1665-5745 https://www.redalyc.org/articulo.oa?id=73020063001 en http://www.redalyc.org/revista.oa?id=730 e-Gnosis application/pdf Universidad de Guadalajara e-Gnosis (México) Vol.9 |
| title | Understanding the Geometric Language of Endothelial Cells Under Flow Condition |
| topic | Multidisciplinarias (Ciencias Sociales) Lamellipodia Cell Behaviour Vectorial Approach Geometric Analysis |
| url | https://www.redalyc.org/articulo.oa?id=73020063001 |