Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedade Brasileira de Geriatria e Gerontologia
2024
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| _version_ | 1876445205487419392 |
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| author | Jarson Pedro da Costa Pereira |
| author_facet | Jarson Pedro da Costa Pereira |
| contents | Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients Jarson Pedro da Costa Pereira Cláudia Porto Sabino Pinho Roana Carolina Bezerra dos Santos Stephany Beatriz do Nascimento Letícia Sabino Santos Taynara de Sousa Rego Mendes José Reginaldo Alves de Queiroz Maria Conceição Chaves de Lemos Alcides da Silva Diniz Poliana Coelho Cabral Multidisciplinaria (Ciencias Naturales y Exactas) aging obesity mortality Underweight body composition Objective: To compare the frequency of underweight and obesity among previously hospitalized older adults and analyze their association with malnutrition, sarcopenia, frailty, inflammatory markers, and adverse outcomes both during hospitalization and after discharge. Methods: This secondary analysis of a prospective study, conducted at Hospital das Clínicas da Universidade Federal de Pernambuco, Brazil, included hospitalized older patients (age ≥ 60 y). Nutritional status, body composition, sarcopenia, frailty, and outcomes were assessed. Cox regression was performed to evaluate the impact of the body mass phenotypes on clinical outcomes. Results: This secondary analysis included one hundred patients. The prevalence of obesity was 22.10%, while that of underweight was 34.60%. Individuals with underweight had a higher frequency of weaker immune response, worse inflammatory profile, higher nutritional risk, higher frequency of sarcopenia and malnutrition, longer hospital stay, and a higher incidence of mortality when compared to those with obesity. Being underweight was independently associated with higher mortality rates, even after adjustment for age, sex, muscle mass, malnutrition, and diagnosis of malignancy [adjusted HR = 2.82 (95% confidence interval 1.03 – 7.72), p = 0.044]. Conclusion: The underweight phenotype represented a worst-case scenario in hospitalized older patients. 2024 artículo científico 2447-2115 https://www.redalyc.org/articulo.oa?id=739777769008 https://www.redalyc.org/journal/7397/739777769008/ https://www.redalyc.org/journal/7397/739777769008/html/ https://www.redalyc.org/journal/7397/739777769008/739777769008.epub https://www.redalyc.org/journal/7397/739777769008/movil https://doi.org/10.53886/gga.e0000143_EN en http://www.redalyc.org/revista.oa?id=7397 Geriatrics, Gerontology and Aging application/pdf Sociedade Brasileira de Geriatria e Gerontologia Geriatrics, Gerontology and Aging (Brasil) Vol.18 |
| format | Artículo científico |
| id | redalyc_739777769008 |
| institution | Redalyc |
| language | en |
| publishDate | 2024 |
| publisher | Sociedade Brasileira de Geriatria e Gerontologia |
| spellingShingle | Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients Jarson Pedro da Costa Pereira Multidisciplinaria (Ciencias Naturales y Exactas) aging obesity mortality Underweight body composition Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients Jarson Pedro da Costa Pereira Cláudia Porto Sabino Pinho Roana Carolina Bezerra dos Santos Stephany Beatriz do Nascimento Letícia Sabino Santos Taynara de Sousa Rego Mendes José Reginaldo Alves de Queiroz Maria Conceição Chaves de Lemos Alcides da Silva Diniz Poliana Coelho Cabral Multidisciplinaria (Ciencias Naturales y Exactas) aging obesity mortality Underweight body composition Objective: To compare the frequency of underweight and obesity among previously hospitalized older adults and analyze their association with malnutrition, sarcopenia, frailty, inflammatory markers, and adverse outcomes both during hospitalization and after discharge. Methods: This secondary analysis of a prospective study, conducted at Hospital das Clínicas da Universidade Federal de Pernambuco, Brazil, included hospitalized older patients (age ≥ 60 y). Nutritional status, body composition, sarcopenia, frailty, and outcomes were assessed. Cox regression was performed to evaluate the impact of the body mass phenotypes on clinical outcomes. Results: This secondary analysis included one hundred patients. The prevalence of obesity was 22.10%, while that of underweight was 34.60%. Individuals with underweight had a higher frequency of weaker immune response, worse inflammatory profile, higher nutritional risk, higher frequency of sarcopenia and malnutrition, longer hospital stay, and a higher incidence of mortality when compared to those with obesity. Being underweight was independently associated with higher mortality rates, even after adjustment for age, sex, muscle mass, malnutrition, and diagnosis of malignancy [adjusted HR = 2.82 (95% confidence interval 1.03 – 7.72), p = 0.044]. Conclusion: The underweight phenotype represented a worst-case scenario in hospitalized older patients. 2024 artículo científico 2447-2115 https://www.redalyc.org/articulo.oa?id=739777769008 https://www.redalyc.org/journal/7397/739777769008/ https://www.redalyc.org/journal/7397/739777769008/html/ https://www.redalyc.org/journal/7397/739777769008/739777769008.epub https://www.redalyc.org/journal/7397/739777769008/movil https://doi.org/10.53886/gga.e0000143_EN en http://www.redalyc.org/revista.oa?id=7397 Geriatrics, Gerontology and Aging application/pdf Sociedade Brasileira de Geriatria e Gerontologia Geriatrics, Gerontology and Aging (Brasil) Vol.18 |
| title | Obesity versus underweight: the prognostic impact of body mass phenotypes in hospitalized older patients |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) aging obesity mortality Underweight body composition |
| url | https://www.redalyc.org/articulo.oa?id=739777769008 https://www.redalyc.org/journal/7397/739777769008/ https://www.redalyc.org/journal/7397/739777769008/html/ https://www.redalyc.org/journal/7397/739777769008/739777769008.epub https://www.redalyc.org/journal/7397/739777769008/movil https://doi.org/10.53886/gga.e0000143_EN |