ARTERIAL HYPERTENSION IMPACT ON CEREBRAL BLOOD FLOW IN PATIENTS WITH ALZHEIMER’S DISEASE
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedade Brasileira de Geriatria e Gerontologia
2017
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| author | Jadwiga Attier Zmudka |
| author_facet | Jadwiga Attier Zmudka |
| contents | ARTERIAL HYPERTENSION IMPACT ON CEREBRAL BLOOD FLOW IN PATIENTS WITH ALZHEIMER’S DISEASE Jadwiga Attier Zmudka Roger Bouzerar Catherine Gondry Frederique Couvillerse Bader Chaarani Olivier Balédenta Multidisciplinaria (Ciencias Naturales y Exactas) Aging hypertension contrast media Alzheimer disease blood flow velocity BACKGROUND: Studies show the potential deterioration of brain vascularization and probable involvement of hypertension in Alzheimer disease (AD). OBJECTIVE: The objective was to evaluate the potential impact of hypertension on cerebral vascular flows in a sample of Alzheimer’s patients. METHODS: 19 patients with AD, including 10 with hypertension (aHT+) and 9 without hypertension (aHT-) were recruited. They underwent clinical evaluation and phase-contrast MRI protocol for flow assessment. Cerebral arterial flow distributions were evaluated using kurtosis and skewness indices at the intracranial and extracranial levels. RESULTS: No significant differences were found in the mean arterial flow, pulse flow and kurtosis between the levels in the AD aHT+ population. There was a significant difference in skewness between extra- and intracranial levels (p = 0.01). No significant differences were found in the mean arterial flow between the levels in the AD aHT- population. A significant difference was observed in the pulse flow (p = 0.03), kurtosis (p = 0.02) and skewness (p = 0.008) between the levels. At the extracranial level we did not find any significant differences in the mean arterial flow, pulse flow or skewness between aHT+ and aHT-. There was a significant difference in kurtosis at the extracranial level between the aHT+ and aHT- (p = 0.03). At the intracranial level, there were no significant differences in all parameters. CONCLUSION: Results showed a difference between cerebral vasculature in AD for aHT+ and aHT- groups. This is probably related to the loss of arterial compliance induced by the degradation of the vascular system. 2017 artículo científico 2447-2115 https://www.redalyc.org/articulo.oa?id=739780702003 en http://www.redalyc.org/revista.oa?id=7397 Geriatrics, Gerontology and Aging application/pdf Sociedade Brasileira de Geriatria e Gerontologia Geriatrics, Gerontology and Aging (Brasil) Num.3 Vol.11 |
| format | Artículo científico |
| id | redalyc_739780702003 |
| language | en |
| publishDate | 2017 |
| publisher | Sociedade Brasileira de Geriatria e Gerontologia |
| spellingShingle | ARTERIAL HYPERTENSION IMPACT ON CEREBRAL BLOOD FLOW IN PATIENTS WITH ALZHEIMER’S DISEASE Jadwiga Attier Zmudka Multidisciplinaria (Ciencias Naturales y Exactas) Aging hypertension contrast media Alzheimer disease blood flow velocity ARTERIAL HYPERTENSION IMPACT ON CEREBRAL BLOOD FLOW IN PATIENTS WITH ALZHEIMER’S DISEASE Jadwiga Attier Zmudka Roger Bouzerar Catherine Gondry Frederique Couvillerse Bader Chaarani Olivier Balédenta Multidisciplinaria (Ciencias Naturales y Exactas) Aging hypertension contrast media Alzheimer disease blood flow velocity BACKGROUND: Studies show the potential deterioration of brain vascularization and probable involvement of hypertension in Alzheimer disease (AD). OBJECTIVE: The objective was to evaluate the potential impact of hypertension on cerebral vascular flows in a sample of Alzheimer’s patients. METHODS: 19 patients with AD, including 10 with hypertension (aHT+) and 9 without hypertension (aHT-) were recruited. They underwent clinical evaluation and phase-contrast MRI protocol for flow assessment. Cerebral arterial flow distributions were evaluated using kurtosis and skewness indices at the intracranial and extracranial levels. RESULTS: No significant differences were found in the mean arterial flow, pulse flow and kurtosis between the levels in the AD aHT+ population. There was a significant difference in skewness between extra- and intracranial levels (p = 0.01). No significant differences were found in the mean arterial flow between the levels in the AD aHT- population. A significant difference was observed in the pulse flow (p = 0.03), kurtosis (p = 0.02) and skewness (p = 0.008) between the levels. At the extracranial level we did not find any significant differences in the mean arterial flow, pulse flow or skewness between aHT+ and aHT-. There was a significant difference in kurtosis at the extracranial level between the aHT+ and aHT- (p = 0.03). At the intracranial level, there were no significant differences in all parameters. CONCLUSION: Results showed a difference between cerebral vasculature in AD for aHT+ and aHT- groups. This is probably related to the loss of arterial compliance induced by the degradation of the vascular system. 2017 artículo científico 2447-2115 https://www.redalyc.org/articulo.oa?id=739780702003 en http://www.redalyc.org/revista.oa?id=7397 Geriatrics, Gerontology and Aging application/pdf Sociedade Brasileira de Geriatria e Gerontologia Geriatrics, Gerontology and Aging (Brasil) Num.3 Vol.11 |
| title | ARTERIAL HYPERTENSION IMPACT ON CEREBRAL BLOOD FLOW IN PATIENTS WITH ALZHEIMER’S DISEASE |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) Aging hypertension contrast media Alzheimer disease blood flow velocity |
| url | https://www.redalyc.org/articulo.oa?id=739780702003 |