SARCOPENIA, LUNG DISEASE AND MORTALITY: A SECONDARY ANALYSIS OF THE CRELES STUDY
Fuente:
Redalyc
Enregistré dans:
| Auteur principal: | |
|---|---|
| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Sociedade Brasileira de Geriatria e Gerontologia
2019
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1876477787459551232 |
|---|---|
| author | Miguel Germán Borda |
| author_facet | Miguel Germán Borda |
| contents | SARCOPENIA, LUNG DISEASE AND MORTALITY: A SECONDARY ANALYSIS OF THE CRELES STUDY Miguel Germán Borda Daniela Patino-Hernandez Carlos Alberto Cano-Gutiérrez Carlos Andrés Celis-Preciado Mario Ulises Pérez-Zepeda Multidisciplinaria (Ciencias Naturales y Exactas) aged mortality Sarcopenia chronic obstructive pulmonary disease AIM: Chronic obstructive pulmonary disease (COPD) is a pro-inflammatory condition leading to wasting states such as sarcopenia. We aimed to describe the effect of COPD and sarcopenia on mortality in Costa Rican older adults in the Costa Rican Longevity and Healthy Aging Study (CRELES). METHOD: This is a secondary analysis of the CRELES, a cohort study consisting of three waves of interviews. For the current study, data from the first and third waves were used. The dependent variable was survival status. COPD and sarcopenia were independent variables. Bivariate analyses were used to compare mortality curves for each group. Association with 3-year mortality was tested with Cox regression models, and hazard ratios (HR) with 95% confidence intervals (CI) were estimated as a measure of the strength of association. RESULTS: Of a total of 2704 participants, 54.29% (n = 1468) were women. Overall mortality was 9.05%. Sarcopenic older adults had the strongest association with mortality (HR = 2.65; 95%CI, 1.81–3.90; p < 0.001), followed by those with both COPD and sarcopenia (HR = 2.59; 95%CI, 1.37–4.92; p = 0.003). The weakest association with mortality was found in patients with neither COPD nor sarcopenia. CONCLUSIONS: The synergistic effect of sarcopenia and COPD has been shown to independently increase mortality in older patients. Our results may be applicable to both Latin American residents and subjects of Hispanic descent living in developed countries. Sarcopenia should be assessed in all patients with COPD since the latter is not a disease limited to the lungs, but rather a systemic disease. 2019 otro 2447-2115 https://www.redalyc.org/articulo.oa?id=739780743010 en http://www.redalyc.org/revista.oa?id=7397 Geriatrics, Gerontology and Aging application/pdf Sociedade Brasileira de Geriatria e Gerontologia Geriatrics, Gerontology and Aging (Brasil) Num.1 Vol.13 |
| format | Artículo científico |
| id | redalyc_739780743010 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedade Brasileira de Geriatria e Gerontologia |
| spellingShingle | SARCOPENIA, LUNG DISEASE AND MORTALITY: A SECONDARY ANALYSIS OF THE CRELES STUDY Miguel Germán Borda Multidisciplinaria (Ciencias Naturales y Exactas) aged mortality Sarcopenia chronic obstructive pulmonary disease SARCOPENIA, LUNG DISEASE AND MORTALITY: A SECONDARY ANALYSIS OF THE CRELES STUDY Miguel Germán Borda Daniela Patino-Hernandez Carlos Alberto Cano-Gutiérrez Carlos Andrés Celis-Preciado Mario Ulises Pérez-Zepeda Multidisciplinaria (Ciencias Naturales y Exactas) aged mortality Sarcopenia chronic obstructive pulmonary disease AIM: Chronic obstructive pulmonary disease (COPD) is a pro-inflammatory condition leading to wasting states such as sarcopenia. We aimed to describe the effect of COPD and sarcopenia on mortality in Costa Rican older adults in the Costa Rican Longevity and Healthy Aging Study (CRELES). METHOD: This is a secondary analysis of the CRELES, a cohort study consisting of three waves of interviews. For the current study, data from the first and third waves were used. The dependent variable was survival status. COPD and sarcopenia were independent variables. Bivariate analyses were used to compare mortality curves for each group. Association with 3-year mortality was tested with Cox regression models, and hazard ratios (HR) with 95% confidence intervals (CI) were estimated as a measure of the strength of association. RESULTS: Of a total of 2704 participants, 54.29% (n = 1468) were women. Overall mortality was 9.05%. Sarcopenic older adults had the strongest association with mortality (HR = 2.65; 95%CI, 1.81–3.90; p < 0.001), followed by those with both COPD and sarcopenia (HR = 2.59; 95%CI, 1.37–4.92; p = 0.003). The weakest association with mortality was found in patients with neither COPD nor sarcopenia. CONCLUSIONS: The synergistic effect of sarcopenia and COPD has been shown to independently increase mortality in older patients. Our results may be applicable to both Latin American residents and subjects of Hispanic descent living in developed countries. Sarcopenia should be assessed in all patients with COPD since the latter is not a disease limited to the lungs, but rather a systemic disease. 2019 otro 2447-2115 https://www.redalyc.org/articulo.oa?id=739780743010 en http://www.redalyc.org/revista.oa?id=7397 Geriatrics, Gerontology and Aging application/pdf Sociedade Brasileira de Geriatria e Gerontologia Geriatrics, Gerontology and Aging (Brasil) Num.1 Vol.13 |
| title | SARCOPENIA, LUNG DISEASE AND MORTALITY: A SECONDARY ANALYSIS OF THE CRELES STUDY |
| topic | Multidisciplinaria (Ciencias Naturales y Exactas) aged mortality Sarcopenia chronic obstructive pulmonary disease |
| url | https://www.redalyc.org/articulo.oa?id=739780743010 |