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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional de Colombia
2006
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| Online Access: | https://www.redalyc.org/articulo.oa?id=77680105 |
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| _version_ | 1866586822552846336 |
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| author | Óscar Alzate |
| author_facet | Óscar Alzate |
| contents | TGF-b and a specific TGF-b inhibitor regulate pericentrin B and MYH9 in glioma cell lines Óscar Alzate Cristina Osorio Michael H. Herbstreith Mark Hjelmeland Robert Buechler Dong Ning He Shideng Bao Jeremy N. Rich Biología TGF DIGE glioma proteomics pericentrin B Malignant gliomas are heterogeneous, highly invasive vascular tumours. The multifunctional cytokine, transforminggrowth factor-beta (TGF-b), is expressed by grade III/IV gliomas and promotes tumour angiogenesis, invasion andimmune escape. It has been shown previously that a small TGF-b receptor type I (TGF-b-RI) molecule inhibitor (SB-431542) blocks TGF-b-mediated signal transduction, induction of angiogenic factor expression and cellular motility.As glioma cell lines display differential sensitivity to TGF-b, it was expected that they would also be differentiallyimpacted by disruption of TGF-b signalling. Differential in gel expression (DIGE) analysis and mass spectrometrywas used in this work for determining protein regulation effects of both TGF-b and SB-431542 on human glioma celllines. It was found that pericentrin B and non muscle myosin were differentially expressed in fragments which likelyresulted from protease activation by the tumour growth mechanism. These results suggest that both pericentrin B andnon-muscle myosin might be potential glioma biomarkers. 2006 artículo científico 0123-3475 https://www.redalyc.org/articulo.oa?id=77680105 en http://www.redalyc.org/revista.oa?id=776 Revista Colombiana de Biotecnología application/pdf Universidad Nacional de Colombia Revista Colombiana de Biotecnología (Colombia) Num.1 Vol.VIII |
| format | Artículo científico |
| id | redalyc_77680105 |
| language | en |
| publishDate | 2006 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | TGF-b and a specific TGF-b inhibitor regulate pericentrin B and MYH9 in glioma cell lines Óscar Alzate Biología TGF DIGE glioma proteomics pericentrin B TGF-b and a specific TGF-b inhibitor regulate pericentrin B and MYH9 in glioma cell lines Óscar Alzate Cristina Osorio Michael H. Herbstreith Mark Hjelmeland Robert Buechler Dong Ning He Shideng Bao Jeremy N. Rich Biología TGF DIGE glioma proteomics pericentrin B Malignant gliomas are heterogeneous, highly invasive vascular tumours. The multifunctional cytokine, transforminggrowth factor-beta (TGF-b), is expressed by grade III/IV gliomas and promotes tumour angiogenesis, invasion andimmune escape. It has been shown previously that a small TGF-b receptor type I (TGF-b-RI) molecule inhibitor (SB-431542) blocks TGF-b-mediated signal transduction, induction of angiogenic factor expression and cellular motility.As glioma cell lines display differential sensitivity to TGF-b, it was expected that they would also be differentiallyimpacted by disruption of TGF-b signalling. Differential in gel expression (DIGE) analysis and mass spectrometrywas used in this work for determining protein regulation effects of both TGF-b and SB-431542 on human glioma celllines. It was found that pericentrin B and non muscle myosin were differentially expressed in fragments which likelyresulted from protease activation by the tumour growth mechanism. These results suggest that both pericentrin B andnon-muscle myosin might be potential glioma biomarkers. 2006 artículo científico 0123-3475 https://www.redalyc.org/articulo.oa?id=77680105 en http://www.redalyc.org/revista.oa?id=776 Revista Colombiana de Biotecnología application/pdf Universidad Nacional de Colombia Revista Colombiana de Biotecnología (Colombia) Num.1 Vol.VIII |
| title | TGF-b and a specific TGF-b inhibitor regulate pericentrin B and MYH9 in glioma cell lines |
| topic | Biología TGF DIGE glioma proteomics pericentrin B |
| url | https://www.redalyc.org/articulo.oa?id=77680105 |