3, 4-methylenedioximethamphetamin reverses anxiety induced by chronic mild stress
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| Format: | Artículo científico |
| Language: | en |
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Universidad del Rosario
2013
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| author | LAURA ANDREA LEÓN A |
| author_facet | LAURA ANDREA LEÓN A |
| contents | 3, 4-methylenedioximethamphetamin reverses anxiety induced by chronic mild stress LAURA ANDREA LEÓN A FERNANDO P. CARDENAS Psicología MDMA maze anxiety serotonin fluoxetine Here we report the effects of subchronic 3, 4-methylene - dioximethamphetamine (MDMA) on the elevated plus- maze, a widely used animal model of anxiety. Rats ex - posed to a mild chronic stress (MCS) protocol received intracerebroventricular microinjections of the selective serotonin reuptake inhibitor (SSRI) – fluoxetine (2.0 ug/ ul) or MDMA, (2.0 ug/ul) for seven days. On the eighth day rats were tested in the elevated plus-maze. Our re - sults showed that sub-chronic MDMA interacted with MCS leading to a decrease in anxiety-related behaviors including: percentage of open arms entries ( F [2, 26] = 4.00; p = 0.031), time spent in the open arms ( F [2, 26] = 3.656; p = 0.040) and time spent in the open arms extremities ( F [2, 26] = 5.842; p = 0.008). These results suggest a po - tential effect of MDMA in the reversion of the emotional significance of aversive stimuli. 2013 artículo científico 1794-4724 https://www.redalyc.org/articulo.oa?id=79928610021 en http://www.redalyc.org/revista.oa?id=799 Avances en Psicología Latinoamericana application/pdf Universidad del Rosario Avances en Psicología Latinoamericana (Colombia) Num.1 Vol.31 |
| format | Artículo científico |
| id | redalyc_79928610021 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Universidad del Rosario |
| spellingShingle | 3, 4-methylenedioximethamphetamin reverses anxiety induced by chronic mild stress LAURA ANDREA LEÓN A Psicología MDMA maze anxiety serotonin fluoxetine 3, 4-methylenedioximethamphetamin reverses anxiety induced by chronic mild stress LAURA ANDREA LEÓN A FERNANDO P. CARDENAS Psicología MDMA maze anxiety serotonin fluoxetine Here we report the effects of subchronic 3, 4-methylene - dioximethamphetamine (MDMA) on the elevated plus- maze, a widely used animal model of anxiety. Rats ex - posed to a mild chronic stress (MCS) protocol received intracerebroventricular microinjections of the selective serotonin reuptake inhibitor (SSRI) – fluoxetine (2.0 ug/ ul) or MDMA, (2.0 ug/ul) for seven days. On the eighth day rats were tested in the elevated plus-maze. Our re - sults showed that sub-chronic MDMA interacted with MCS leading to a decrease in anxiety-related behaviors including: percentage of open arms entries ( F [2, 26] = 4.00; p = 0.031), time spent in the open arms ( F [2, 26] = 3.656; p = 0.040) and time spent in the open arms extremities ( F [2, 26] = 5.842; p = 0.008). These results suggest a po - tential effect of MDMA in the reversion of the emotional significance of aversive stimuli. 2013 artículo científico 1794-4724 https://www.redalyc.org/articulo.oa?id=79928610021 en http://www.redalyc.org/revista.oa?id=799 Avances en Psicología Latinoamericana application/pdf Universidad del Rosario Avances en Psicología Latinoamericana (Colombia) Num.1 Vol.31 |
| title | 3, 4-methylenedioximethamphetamin reverses anxiety induced by chronic mild stress |
| topic | Psicología MDMA maze anxiety serotonin fluoxetine |
| url | https://www.redalyc.org/articulo.oa?id=79928610021 |