Una aproximación al significado biológico del polimorfismo del Complejo Mayor de Histocompatibilidad. El modelo de la asociación HLA y ARJ
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| Format: | Artículo científico |
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Universidad del Norte
2002
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| author | Gloria Garavito |
| author_facet | Gloria Garavito |
| contents | Una aproximación al significado biológico del polimorfismo del Complejo Mayor de Histocompatibilidad. El modelo de la asociación HLA y ARJ Gloria Garavito Eduardo E. Egea Eduardo Enrique Egea Dolores Jaraquemada Paz Martínez Antonio Iglesias Salud juvenile rheumatoid arthritis (JRA) Major Histocompatibility Complex (MHC) Objectives. To carry out an updating of the state of the art about the biological meaning of geneticsystem polymorphism Major Histocompatibility Complex (MHC). To review the literature related tothe association of histocompatibility antigens in humans (HLA) and the susceptibility or resistanceto the development of Juvenile Rheumatoid Arthritis (JRA). To present a hypothetical model tounderstand the genetic susceptibility to develop JRA.Data source. The bibliographic references supporting this paper were obtained through searching inthe following data base: Pubmed, Ovid, Ebsco. Initially, 139 articles were found, from which 75 wereselected . Information about the development of a research of our group, «Molecular polymorphism ofHLA and JRA antigens» was also included. (Colciencias code Nº 1215-04-280-96).Results. Juvenile rheumatoid Arthritis (JRA) is the most common disease in pediatric rheumatologicpractice as well as the one with less immunogenetic studies. Contrary to the adult rheumatoid arthritis(RA), JRA has certain clinical variants which make it more interesting from the genetic point of view(phenotypes). In its pathogenesis several factors have been identified, which as a whole would explainthe onset and the perpetuation of the inflammatory response affecting joints and nearby tissue as wellas its imminent destruction given no control of it as is the case in other autoimmune diseases. Thedisease pathogenesis can be determined by alterations at the trimolecular level formed by a putativeantigen: lymphocyte T receptor and the Major Histocampatibility Complex (MHC).During the last four years our group has been studying the link between JRA and the HLA DRB1*and DQB1* alleles in mestizo children of our country. Results are congruent with the findingsdescribed in the literature by different investigation groups. In the series of patients studied, we havefound that the alleles HLA DRB1* 1104, HLA*0701 and HLA*1602 are linked to the susceptibilityof developing JRA. Our data also show that the alleles HLA DRB1* 1501 y HLA DQB1* 0602 areclearly linked to protection.It is important to highlight that all the alleles linked to susceptibility share the Asp amino acid inposition 70, and those shown as protection markers have Val in the same position.Conclusion. The information obtained from the literature and the findings in our series of Colombianpatients are relevant and important because from the molecular point of view, at an antigenicpresentation level, the amino acid in position 70 in the motif 67 to 73, at HLA molecule level, couldactivate TH1 or TH2 cells, which would be compromised in the immunopathology of this entity. Othergenetic or/and environmental factors linked to these molecular characteristics expressed at the level ofthe HLA molecule and compromised in the antigenic response could interact and its result would beinfluencing the development and the expression of JRA 2002 artículo científico 0120-5552 https://www.redalyc.org/articulo.oa?id=81701607 en http://www.redalyc.org/revista.oa?id=817 Salud Uninorte application/pdf Universidad del Norte Salud Uninorte (Colombia) Num.16 |
| format | Artículo científico |
| id | redalyc_81701607 |
| institution | Redalyc |
| language | en |
| publishDate | 2002 |
| publisher | Universidad del Norte |
| spellingShingle | Una aproximación al significado biológico del polimorfismo del Complejo Mayor de Histocompatibilidad. El modelo de la asociación HLA y ARJ Gloria Garavito Salud juvenile rheumatoid arthritis (JRA) Major Histocompatibility Complex (MHC) Una aproximación al significado biológico del polimorfismo del Complejo Mayor de Histocompatibilidad. El modelo de la asociación HLA y ARJ Gloria Garavito Eduardo E. Egea Eduardo Enrique Egea Dolores Jaraquemada Paz Martínez Antonio Iglesias Salud juvenile rheumatoid arthritis (JRA) Major Histocompatibility Complex (MHC) Objectives. To carry out an updating of the state of the art about the biological meaning of geneticsystem polymorphism Major Histocompatibility Complex (MHC). To review the literature related tothe association of histocompatibility antigens in humans (HLA) and the susceptibility or resistanceto the development of Juvenile Rheumatoid Arthritis (JRA). To present a hypothetical model tounderstand the genetic susceptibility to develop JRA.Data source. The bibliographic references supporting this paper were obtained through searching inthe following data base: Pubmed, Ovid, Ebsco. Initially, 139 articles were found, from which 75 wereselected . Information about the development of a research of our group, «Molecular polymorphism ofHLA and JRA antigens» was also included. (Colciencias code Nº 1215-04-280-96).Results. Juvenile rheumatoid Arthritis (JRA) is the most common disease in pediatric rheumatologicpractice as well as the one with less immunogenetic studies. Contrary to the adult rheumatoid arthritis(RA), JRA has certain clinical variants which make it more interesting from the genetic point of view(phenotypes). In its pathogenesis several factors have been identified, which as a whole would explainthe onset and the perpetuation of the inflammatory response affecting joints and nearby tissue as wellas its imminent destruction given no control of it as is the case in other autoimmune diseases. Thedisease pathogenesis can be determined by alterations at the trimolecular level formed by a putativeantigen: lymphocyte T receptor and the Major Histocampatibility Complex (MHC).During the last four years our group has been studying the link between JRA and the HLA DRB1*and DQB1* alleles in mestizo children of our country. Results are congruent with the findingsdescribed in the literature by different investigation groups. In the series of patients studied, we havefound that the alleles HLA DRB1* 1104, HLA*0701 and HLA*1602 are linked to the susceptibilityof developing JRA. Our data also show that the alleles HLA DRB1* 1501 y HLA DQB1* 0602 areclearly linked to protection.It is important to highlight that all the alleles linked to susceptibility share the Asp amino acid inposition 70, and those shown as protection markers have Val in the same position.Conclusion. The information obtained from the literature and the findings in our series of Colombianpatients are relevant and important because from the molecular point of view, at an antigenicpresentation level, the amino acid in position 70 in the motif 67 to 73, at HLA molecule level, couldactivate TH1 or TH2 cells, which would be compromised in the immunopathology of this entity. Othergenetic or/and environmental factors linked to these molecular characteristics expressed at the level ofthe HLA molecule and compromised in the antigenic response could interact and its result would beinfluencing the development and the expression of JRA 2002 artículo científico 0120-5552 https://www.redalyc.org/articulo.oa?id=81701607 en http://www.redalyc.org/revista.oa?id=817 Salud Uninorte application/pdf Universidad del Norte Salud Uninorte (Colombia) Num.16 |
| title | Una aproximación al significado biológico del polimorfismo del Complejo Mayor de Histocompatibilidad. El modelo de la asociación HLA y ARJ |
| topic | Salud juvenile rheumatoid arthritis (JRA) Major Histocompatibility Complex (MHC) |
| url | https://www.redalyc.org/articulo.oa?id=81701607 |