Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Universidad del Norte
2018
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=81759607021 https://www.redalyc.org/journal/817/81759607021/ https://www.redalyc.org/journal/817/81759607021/html/ https://www.redalyc.org/journal/817/81759607021/81759607021.epub https://www.redalyc.org/journal/817/81759607021/movil |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Applied genomic in cerebrovascular disease Hugo Sánchez Hernández Alma Ortiz Plata Febe E. Cázares Raga Iris A. Nava Jiménez Fidel de la Cruz Hernández-Hernández Salud genetic expression Cellular adaptation experimental models cerebrovascular disease Cerebrovascular disease involve the alterations caused by pathology process of the sanguineous vessels, affecting one or many brain areas. Cerebrovascular disease is also known like stroke or ictus; it is the third cause of death around the world and is the neurologic pathology with the most prevalence rate. Cerebrovascular disease induces several changes in genetic expression inside the neurovascular unit (glia cells, neurons and ependymal cells); principally, changes in the oxidative stress and calcium inflow into the cells, this could start cellular death and tissue destruction, causing an irreversible injury in brain, losing several functions. The injury causes the activation of signaling pathways to respond to the stress, where many molecules such as proteins and mRNA are involved to act as intermediaries to activate or deactivate stress mechanisms; these molecules are able to transmit extracellular signals into the nucleus activating early gene expression like proto-oncogenes and several transcription factors to repair the cerebral injury. It is important to know the relation of the changes in genetic expression and proteins to avoid the development of injury and to activate the brain recovery. This knowledge let us diagnose the injury rate and propose therapeutic mechanisms to reduce or avoid the adverse effects on time, before the cellular death start. 2018 reseña 0120-5552 https://www.redalyc.org/articulo.oa?id=81759607021 https://www.redalyc.org/journal/817/81759607021/ https://www.redalyc.org/journal/817/81759607021/html/ https://www.redalyc.org/journal/817/81759607021/81759607021.epub https://www.redalyc.org/journal/817/81759607021/movil en http://www.redalyc.org/revista.oa?id=817 Salud Uninorte application/pdf Universidad del Norte Salud Uninorte (Colombia) Num.3 Vol.34