Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Instituto Nacional de Salud
2001
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=84321409 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Serum IGF-I and IGFBP-3 levels in pregnant adolescents in an economically depressed community Stella Carrasco Rodríguez Myriam Sánchez Gómez Medicina IGFBP pregnancy words: IGF adolescence malnutrition The growth hormone (GH)/insulin-like growth factor-l (IGF-1) axis is believed to play a role ingrowth during postnatal and fetal life and is regulatedhy nutrition. However, very few studieshave examined the effects of malnutrition on the regulation of the GHIIGF-I axis in humanpregnancy during adolescence. In this study we compared the serum IGF-I and IGFBP-3levels in a group (n=62) of pregnant adolescents in their second trimester of pregnancy and -living in a poor area in the city of Bogotá. with those of a group (n=36) of non-pregnantadolescents from the same area. As reference, a group (n=20) of non-pregnant adolescentsfrom amiddle-class district in the same city was utilized. It was observed that the nonpregnantadolescents from the poor area were al1 below the 3´* percentile and showedsignificantly (p<0.05) reduced height and weight in comparison with subjects from middleclassarea, suggesting growth retardation in this group of subjects. Serum IGF-I and IGFBP-3levels were significantly (p<0.0001) reduced, in comparison with subjects from the middleclassarea, although there was no evidence of delay of puberty based on Tanner stage ofsexual development and only subjects at Tanner 5 were included in this study. When theserum concentrations of IGF-I and IGFB-3 in the population of pregnant adolescents wereinvestigated, no differences were found with those observed in the non-pregnant adolescentsfrom the poor district. which means that pregnancy was not accompanied by the elevation inIGF-I levels observed in normal pregnancies. In conclusion, the low circulating IGF-I levelsobserved in pregnant adolescents could mirror abnormalities on the normal physiology of theGHIIGF-I axis. whose effects on fetal growth are not completely understood 2001 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84321409 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.4 Vol.21