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| Format: | Artículo científico |
| Language: | en |
| Published: |
Instituto Nacional de Salud
2002
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| Online Access: | https://www.redalyc.org/articulo.oa?id=84322205 |
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Table of Contents:
- Dilataciones bronquiales crónicas endiferentes colonias de ratas de laboratorio Silvana Marisa Montenegro María Cristina Tarrés Juan Carlos Picena Stella Maris Martínez Ariana Erazo Fernanda Beduino María Isabel Luciano Gustavo Pizzutti Juan Carlos Miguel Medicina rat lung diabetes bronchiectasis Bronchiectasis occurred naturally in 12-month-old spontaneously diabetic eSS male rats. Thelungs of 3 and 6-month-old eSS rats were compared in eumetabolic eSS rats from three inbredlines consisting of inbred spontaneously diabetic eSS derived from IIM strain; these werecompared with eumetabolic, outbred Wistar rats, paired by sex and age. Acrylic casts of bronchialtree were obtained after injection of a plastic substance. The casts were pruned to focus on thefirst four bronchial branchings. Diameter and volume of the conductive bronchial tree weredetermined using a binocular magnifier. Histological sections were obtained. All lines showedmultiple bronchiectasis, mostly fusiform, bronchial dilatation and inflammatory response withlymphocytic infiltrates. These symptoms were much more severe in 180-day-old eSS males.Bacteria were isolated from the lungs in 70% of cases (n=32), except in eSS rats. Pseudomonaspp. (38%) and Gram-positive cocci as coagulase-negative Staphylococcus spp. (20%) weredetected. Neither pathogenic bacteria nor saprophyte fungi were found. Although all lines wereaffected, diabetes in eSS appears to be an aggravating factor 2002 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84322205 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.2 Vol.22