Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia
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| Natura: | Artículo científico |
| Lingua: | en |
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Instituto Nacional de Salud
2003
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| _version_ | 1876434603635376128 |
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| author | Adriana Pérez |
| author_facet | Adriana Pérez |
| contents | Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia Adriana Pérez Juan F. Sánchez Luis F. Pinto José F. Molina María C. Londoño Martha E. Cadavid Gustavo Matute Mauricio Uribe Juan Manuel Anaya Medicina Colombia risk factors hypertension autoantibodies hyperlipidemia A cross-sectional and multicenter study was undertaken to analyze the clinical andimmunological characteristics at diagnosis associated with nephritis in northwesternColombian patients with systemic lupus erythematosus (SLE). Thirty nine patients with lupusnephritis were included and were compared to 100 SLE patients without nephritis. A multivariateanalysis was performed. The patients who developed nephritis had a higher frequency of oralulcers (41% vs. 21%, OR=3.1, 95%CI: 1.3-7.5 p= 0.01) and malar erythema (77% vs. 45%,OR=4.4, 95%CI: 1.8-10.8 p=0.001). Lupus nephritis was observed in 77% of cases during thefirst year of the disease. The frequency of anti-DNA antibodies was higher in patients withnephritis, however, differences were not statistically significant (83% vs 64%, OR=2.6, 95%CI:1.03-6.41, p=0.06). The presence of other autoantibodies (anti-Ro, anti-La, anti-RNP, anti-Smand anticardiolipin) at diagnosis was similar in both groups. This autoantibody profile remainedunchanged throughout the evolution of the disease. Patients with lupus nephritis had a higherprevalence of arterial hypertension (60% vs 10%, OR=13.7, 95%IC: 5-37, p=0.00001) andhyperlipidemia (30% vs 7%, OR=8.1, 95%IC: 2.5-27, p=0.0006) at onset. Finally, patients withlupus nephritis required more hospitalizations (>1) over the course of disease (89% vs 60%,OR=7.8, 95%CI: 2.129, p=0.002). In conclusion, lupus nephritis appears early during thecourse of SLE. Malar erythema, oral ulcers, hypertension and hyperlipidemia at onset of diseaseare associated factors. Lupus nephritis is a major risk factor leading to repeatedhospitalizations. This study may help to assist in public health policies in our population inorder to improve patient outcomes while simultaneously reducing disease costs 2003 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84323306 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.3 Vol.23 |
| format | Artículo científico |
| id | redalyc_84323306 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Instituto Nacional de Salud |
| spellingShingle | Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia Adriana Pérez Medicina Colombia risk factors hypertension autoantibodies hyperlipidemia Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia Adriana Pérez Juan F. Sánchez Luis F. Pinto José F. Molina María C. Londoño Martha E. Cadavid Gustavo Matute Mauricio Uribe Juan Manuel Anaya Medicina Colombia risk factors hypertension autoantibodies hyperlipidemia A cross-sectional and multicenter study was undertaken to analyze the clinical andimmunological characteristics at diagnosis associated with nephritis in northwesternColombian patients with systemic lupus erythematosus (SLE). Thirty nine patients with lupusnephritis were included and were compared to 100 SLE patients without nephritis. A multivariateanalysis was performed. The patients who developed nephritis had a higher frequency of oralulcers (41% vs. 21%, OR=3.1, 95%CI: 1.3-7.5 p= 0.01) and malar erythema (77% vs. 45%,OR=4.4, 95%CI: 1.8-10.8 p=0.001). Lupus nephritis was observed in 77% of cases during thefirst year of the disease. The frequency of anti-DNA antibodies was higher in patients withnephritis, however, differences were not statistically significant (83% vs 64%, OR=2.6, 95%CI:1.03-6.41, p=0.06). The presence of other autoantibodies (anti-Ro, anti-La, anti-RNP, anti-Smand anticardiolipin) at diagnosis was similar in both groups. This autoantibody profile remainedunchanged throughout the evolution of the disease. Patients with lupus nephritis had a higherprevalence of arterial hypertension (60% vs 10%, OR=13.7, 95%IC: 5-37, p=0.00001) andhyperlipidemia (30% vs 7%, OR=8.1, 95%IC: 2.5-27, p=0.0006) at onset. Finally, patients withlupus nephritis required more hospitalizations (>1) over the course of disease (89% vs 60%,OR=7.8, 95%CI: 2.129, p=0.002). In conclusion, lupus nephritis appears early during thecourse of SLE. Malar erythema, oral ulcers, hypertension and hyperlipidemia at onset of diseaseare associated factors. Lupus nephritis is a major risk factor leading to repeatedhospitalizations. This study may help to assist in public health policies in our population inorder to improve patient outcomes while simultaneously reducing disease costs 2003 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84323306 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.3 Vol.23 |
| title | Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia |
| topic | Medicina Colombia risk factors hypertension autoantibodies hyperlipidemia |
| url | https://www.redalyc.org/articulo.oa?id=84323306 |