Staphylococcus aureus resistente a vancomicina
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| Format: | Artículo científico |
| Langue: | es |
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Instituto Nacional de Salud
2005
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| _version_ | 1876463689440165888 |
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| author | Carlos Andrés Rodríguez |
| author_facet | Carlos Andrés Rodríguez |
| contents | Staphylococcus aureus resistente a vancomicina Carlos Andrés Rodríguez Omar Vesga Medicina microbial vancomycin antibiotics biosynthesis glycopeptide The evolution and molecular mechanisms of vancomycin resistance in Staphylococcus aureuswere reviewed. Case reports and research studies on biochemestry, electron microscopy andmolecular biology of Staphylococcus aureus were selected from Medline database andsummarized in the following review. After almost 40 years of successful treatment of S. aureuswith vancomycin, several cases of clinical failures have been reported (since 1997). S. aureusstrains have appeared with intermediate susceptibility (MIC 8-16 µg/ml), as well as strains withheterogeneous resistance (global MIC £ 4 µg/ml), but with subpopulations of intermediatesusceptibility. In these cases, resistance is mediated by cell wall thickening with reduced crosslinking. This traps the antibiotic before it reaches its major target, the murein monomers in thecell membrane. In 2002, a total vancomycin resistant strain (MIC ³ 32 µg/ml) was reported withvanA genes from Enterococcus spp. These genes induce the change of D-Ala-D-Ala terminusfor D-Ala-D-lactate in the cell wall precursors, leading to loss of affinity for glycopeptides.Vancomycin resistance in S. aureus has appeared; it is mediated by cell wall modifications thattrap the antibiotic before it reaches its action site. In strains with total resistance, Enterococcusspp. genes have been acquired that lead to modification of the glycopeptide target 2005 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84325418 es http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.4 Vol.25 |
| format | Artículo científico |
| id | redalyc_84325418 |
| institution | Redalyc |
| language | es |
| publishDate | 2005 |
| publisher | Instituto Nacional de Salud |
| spellingShingle | Staphylococcus aureus resistente a vancomicina Carlos Andrés Rodríguez Medicina microbial vancomycin antibiotics biosynthesis glycopeptide Staphylococcus aureus resistente a vancomicina Carlos Andrés Rodríguez Omar Vesga Medicina microbial vancomycin antibiotics biosynthesis glycopeptide The evolution and molecular mechanisms of vancomycin resistance in Staphylococcus aureuswere reviewed. Case reports and research studies on biochemestry, electron microscopy andmolecular biology of Staphylococcus aureus were selected from Medline database andsummarized in the following review. After almost 40 years of successful treatment of S. aureuswith vancomycin, several cases of clinical failures have been reported (since 1997). S. aureusstrains have appeared with intermediate susceptibility (MIC 8-16 µg/ml), as well as strains withheterogeneous resistance (global MIC £ 4 µg/ml), but with subpopulations of intermediatesusceptibility. In these cases, resistance is mediated by cell wall thickening with reduced crosslinking. This traps the antibiotic before it reaches its major target, the murein monomers in thecell membrane. In 2002, a total vancomycin resistant strain (MIC ³ 32 µg/ml) was reported withvanA genes from Enterococcus spp. These genes induce the change of D-Ala-D-Ala terminusfor D-Ala-D-lactate in the cell wall precursors, leading to loss of affinity for glycopeptides.Vancomycin resistance in S. aureus has appeared; it is mediated by cell wall modifications thattrap the antibiotic before it reaches its action site. In strains with total resistance, Enterococcusspp. genes have been acquired that lead to modification of the glycopeptide target 2005 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84325418 es http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.4 Vol.25 |
| title | Staphylococcus aureus resistente a vancomicina |
| topic | Medicina microbial vancomycin antibiotics biosynthesis glycopeptide |
| url | https://www.redalyc.org/articulo.oa?id=84325418 |