Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer
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| Natura: | Artículo científico |
| Lingua: | en |
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Instituto Nacional de Salud
2006
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| _version_ | 1876477132047122432 |
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| author | Ricardo Cendales |
| author_facet | Ricardo Cendales |
| contents | Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer Ricardo Cendales Martha Lucía Serrano Alfredo Romero Myriam Sánchez-Gómez María Mercedes Bravo Medicina insulin cervical neoplasms cervical dysplasia like growth factor I like growth factor II Introduction. Pap smear has limitations as a screening test for cervical cancer. A marker thatallows the identification of women who are at risk of developing cervical cancer would be usefulfor its prevention. A growing number of studies have demonstrated an association betweeninsulin-like growth factors (IGF) serum levels and increased risk for various cancers.Objective. To assess whether circulating IGF-I, IGF-II, or IGF binding protein 3 (IGFBP-3) wereassociated with cervical cancer and low-grade and high-grade squamous intraepithelial lesions(LSIL and HSIL).Materials and methods. Serum levels of IGF-I, IGF-II and IGFBP-3 were measured by ELISA.Three groups of cases were analyzed: LSIL (n = 37), HSIL (n = 57), and cervical cancer (n = 41).For each case, two controls, matched by age, were included. Control subjects were womenwith normal, HPV-DNA-negative Pap smear.Results. Significantly lower values of IGF-I (83.9 ng/ml versus 126.6 ng/ml, p < 0.001) and IGF-I:IGFBP-3 molar ratio (0.094 versus 0.137, p < 0.001) were observed among cancer cases, ascompared to their control group. Women in the highest quartile of IGF-I and IGF-I:IGFBP-3molar ratio were at an 80% (OR = 0.2, 95% CI [0.06-0.61]) and a 77% (OR = 0.23, 95% CI [0.07-0.73]) lower risk of cervical cancer, respectively, compared with women in the correspondingreference category.Conclusions. These data suggest that low values of IGF-I and IGF-I:IGFBP-3 molar ratio maybe associated with cervical cancer. 2006 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84326209 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.2 Vol.26 |
| format | Artículo científico |
| id | redalyc_84326209 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Instituto Nacional de Salud |
| spellingShingle | Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer Ricardo Cendales Medicina insulin cervical neoplasms cervical dysplasia like growth factor I like growth factor II Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer Ricardo Cendales Martha Lucía Serrano Alfredo Romero Myriam Sánchez-Gómez María Mercedes Bravo Medicina insulin cervical neoplasms cervical dysplasia like growth factor I like growth factor II Introduction. Pap smear has limitations as a screening test for cervical cancer. A marker thatallows the identification of women who are at risk of developing cervical cancer would be usefulfor its prevention. A growing number of studies have demonstrated an association betweeninsulin-like growth factors (IGF) serum levels and increased risk for various cancers.Objective. To assess whether circulating IGF-I, IGF-II, or IGF binding protein 3 (IGFBP-3) wereassociated with cervical cancer and low-grade and high-grade squamous intraepithelial lesions(LSIL and HSIL).Materials and methods. Serum levels of IGF-I, IGF-II and IGFBP-3 were measured by ELISA.Three groups of cases were analyzed: LSIL (n = 37), HSIL (n = 57), and cervical cancer (n = 41).For each case, two controls, matched by age, were included. Control subjects were womenwith normal, HPV-DNA-negative Pap smear.Results. Significantly lower values of IGF-I (83.9 ng/ml versus 126.6 ng/ml, p < 0.001) and IGF-I:IGFBP-3 molar ratio (0.094 versus 0.137, p < 0.001) were observed among cancer cases, ascompared to their control group. Women in the highest quartile of IGF-I and IGF-I:IGFBP-3molar ratio were at an 80% (OR = 0.2, 95% CI [0.06-0.61]) and a 77% (OR = 0.23, 95% CI [0.07-0.73]) lower risk of cervical cancer, respectively, compared with women in the correspondingreference category.Conclusions. These data suggest that low values of IGF-I and IGF-I:IGFBP-3 molar ratio maybe associated with cervical cancer. 2006 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84326209 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.2 Vol.26 |
| title | Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer |
| topic | Medicina insulin cervical neoplasms cervical dysplasia like growth factor I like growth factor II |
| url | https://www.redalyc.org/articulo.oa?id=84326209 |