Rickettsial infection in capybaras ( Hydrochoerus hydrochaeris) from São Paulo, Brazil: serological evidence for infection by Rickettsia bellii and Rickettsia parkeri
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| Natura: | Artículo científico |
| Lingua: | es |
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Instituto Nacional de Salud
2007
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| _version_ | 1876447596996722688 |
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| author | Richard C. Pacheco |
| author_facet | Richard C. Pacheco |
| contents | Rickettsial infection in capybaras ( Hydrochoerus hydrochaeris) from São Paulo, Brazil: serological evidence for infection by Rickettsia bellii and Rickettsia parkeri Richard C. Pacheco Mauricio C. Horta Jonas Moraes-Filho Alexandre C. Ataliba Marcelo B. Labruna Adriano Pinter Medicina Brazil rodentia serology zoonoses diagnosis Introduction. In Brazil, capybaras (Hydrochoerus hydrochaeris) are important hosts forAmblyomma ticks, which in turn can transmit rickettsiae to humans and animals. Therefore,capybaras are potential sentinels for rickettsial infection.Objective. The present study evaluated rickettsial infection in capybaras in different areas ofthe state of São Paulo, where rickettsiosis has never been reported.Materials and methods. Blood sera from 73 capybaras from six localities in São Paulo weretested by indirect immunofluorescence assay using Rickettsia rickettsii, Rickettsia parkeri, andRickettsia bellii antigens. Capybara spleens were tested by PCR, targeting a fragment of therickettsial gltA gene. Ticks were collected from each capybara sample and taxonomicallyidentified to species.Results. A total of 94 positively reacting capybara samples, 19 (26.0%), 25 (34.2%), and 50(68.5%) capybara sera reacted to R. rickettsii, R. parkeri, and R. bellii, respectively. Twenty-fivecapybara sera showed titers to R. bellii at least four-fold higher than to any of the other twoantigens. These sera were considered homologous to R. bellii. Using the same criteria, 3capybara sera were considered homologous to R. parkeri. No sera were be consideredhomologous to R. rickettsii. No rickettsial DNA was detected in capybara spleen samples. Tickscollected on capybaras were Amblyomma dubitatum and Amblyomma cajennense.Conclusions. The first evidence is reported of R. bellii natural infection in vertebrate hosts, andthe first evidence of R. parkeri infection in capybaras. While R. parkeri is known to infect andcause disease in humans, no similar evidence for human infection has been indicated by R.bellii. 2007 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84327306 es http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.3 Vol.27 |
| format | Artículo científico |
| id | redalyc_84327306 |
| institution | Redalyc |
| language | es |
| publishDate | 2007 |
| publisher | Instituto Nacional de Salud |
| spellingShingle | Rickettsial infection in capybaras ( Hydrochoerus hydrochaeris) from São Paulo, Brazil: serological evidence for infection by Rickettsia bellii and Rickettsia parkeri Richard C. Pacheco Medicina Brazil rodentia serology zoonoses diagnosis Rickettsial infection in capybaras ( Hydrochoerus hydrochaeris) from São Paulo, Brazil: serological evidence for infection by Rickettsia bellii and Rickettsia parkeri Richard C. Pacheco Mauricio C. Horta Jonas Moraes-Filho Alexandre C. Ataliba Marcelo B. Labruna Adriano Pinter Medicina Brazil rodentia serology zoonoses diagnosis Introduction. In Brazil, capybaras (Hydrochoerus hydrochaeris) are important hosts forAmblyomma ticks, which in turn can transmit rickettsiae to humans and animals. Therefore,capybaras are potential sentinels for rickettsial infection.Objective. The present study evaluated rickettsial infection in capybaras in different areas ofthe state of São Paulo, where rickettsiosis has never been reported.Materials and methods. Blood sera from 73 capybaras from six localities in São Paulo weretested by indirect immunofluorescence assay using Rickettsia rickettsii, Rickettsia parkeri, andRickettsia bellii antigens. Capybara spleens were tested by PCR, targeting a fragment of therickettsial gltA gene. Ticks were collected from each capybara sample and taxonomicallyidentified to species.Results. A total of 94 positively reacting capybara samples, 19 (26.0%), 25 (34.2%), and 50(68.5%) capybara sera reacted to R. rickettsii, R. parkeri, and R. bellii, respectively. Twenty-fivecapybara sera showed titers to R. bellii at least four-fold higher than to any of the other twoantigens. These sera were considered homologous to R. bellii. Using the same criteria, 3capybara sera were considered homologous to R. parkeri. No sera were be consideredhomologous to R. rickettsii. No rickettsial DNA was detected in capybara spleen samples. Tickscollected on capybaras were Amblyomma dubitatum and Amblyomma cajennense.Conclusions. The first evidence is reported of R. bellii natural infection in vertebrate hosts, andthe first evidence of R. parkeri infection in capybaras. While R. parkeri is known to infect andcause disease in humans, no similar evidence for human infection has been indicated by R.bellii. 2007 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84327306 es http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.3 Vol.27 |
| title | Rickettsial infection in capybaras ( Hydrochoerus hydrochaeris) from São Paulo, Brazil: serological evidence for infection by Rickettsia bellii and Rickettsia parkeri |
| topic | Medicina Brazil rodentia serology zoonoses diagnosis |
| url | https://www.redalyc.org/articulo.oa?id=84327306 |