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Dettagli Bibliografici
Autore principale:	Harvy Mauricio Velasco
Natura:	Artículo científico
Lingua:	es
Pubblicazione:	Instituto Nacional de Salud 2017
Soggetti:	Medicina genética estatura Colombia esqueleto Enfermedades del desarrollo óseo
Accesso online:	https://www.redalyc.org/articulo.oa?id=84350981015 https://www.redalyc.org/journal/843/84350981015/ https://www.redalyc.org/journal/843/84350981015/html/ https://www.redalyc.org/journal/843/84350981015/84350981015.epub https://www.redalyc.org/journal/843/84350981015/movil
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Caracterización de pacientes con enfermedades genéticas del esqueleto en un centro colombiano de remisión Harvy Mauricio Velasco Lina Patricia Buelvas Medicina genética estatura Colombia esqueleto Enfermedades del desarrollo óseo Introducción. La prevalencia de talla baja en Colombia es de 10 %, aproximadamente. En el 2009, la International Skeletal Dysplasia Society incluyó 456 condiciones clínicas en su clasificación, con base en criterios bioquímicos, radiológicos y moleculares para su diagnóstico. Objetivo. Analizar las variables demográficas, epidemiológicas y clínicas en un grupo de pacientes con enfermedades genéticas del esqueleto, remitidos al Instituto de Ortopedia Infantil Roosevelt. Materiales y métodos. Se analizaron pacientes remitidos entre el 2008 y el 2014, con 167 diagnósticos relacionados con enfermedades genéticas del esqueleto según la Clasificación Internacional de Enfermedades, versión 2010 (CIE-10). Se exploraron las variables demográficas, epidemiológicas y clínicas empleando estadística descriptiva. Se generó una puntuación para las intervenciones que contempló las combinaciones de tratamientos, y se analizaron las variables mediante la prueba t de Student. Resultados. El motivo de consulta más frecuente fue por sospecha de enfermedad genética del esqueleto. Entre los tipos de tratamiento, se consideraron los de soporte, los quirúrgicos, el farmacológico y la ‘ortesis’, y se pudo establecer que los pacientes con enfermedades genéticas del esqueleto obtenían puntajes mayores en la variable de intervención y menores en las de talla alta y baja. Conclusiones. El diagnóstico de la mayoría de los pacientes remitidos respondía a enfermedades genéticas del esqueleto, talla baja y otras enfermedades genéticas monogénicas. Se encontraron diferencias significativas entre la edad de inicio de los síntomas y la de diagnóstico, así como diversos enfoques terapéuticos. Hubo menos intervenciones en los pacientes con talla alta y baja, lo cual podría alertar sobre la necesidad de reevaluar las necesidades terapéuticas de este grupo. 2017 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84350981015 https://www.redalyc.org/journal/843/84350981015/ https://www.redalyc.org/journal/843/84350981015/html/ https://www.redalyc.org/journal/843/84350981015/84350981015.epub https://www.redalyc.org/journal/843/84350981015/movil es http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.2 Vol.37

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// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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