Survival analysis and associated factors of high-grade glioma patients
Fuente:
Redalyc
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Instituto Nacional de Salud
2024
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1876457442158575616 |
|---|---|
| author | Lina Marcela Barrera |
| author_facet | Lina Marcela Barrera |
| contents | Survival analysis and associated factors of high-grade glioma patients Lina Marcela Barrera León Darío Ortiz Hugo de Jesús Grisales Mauricio Camargo Medicina Glioma Kaplan genetics prognosis risk factors Introduction. High-grade gliomas are the most common primary brain tumors in adults, and they usually have a quick fatal course. Average survival is 18 months, mainly, because of tumor resistance to Stupp protocol.Objective. To determine high-grade glioma patient survival and the effect of persuasion variables on survival.Materials and methods. We conducted a longitudinal descriptive study in which 80 untreated recently diagnosed high-grade glioma patients participated. A survey was conducted regarding their exposure to some risk factors, degree of genetic instability in peripheral blood using micronucleus quantification on binuclear lymphocytes, micronuclei in reticulocytes and sister-chromatid exchanges in lymphocytes. In the statistical analysis, this study constructed life tables, used the Kaplan-Meier, and the log-rank test, and in the multivariate analysis, a Cox proportional hazards model was constructed. Results. Eighty patients' clinical, demographic and lifestyle characteristics were analyzed, as well as their survival rates and the average survival time is 784 days (interquartile range: 928). Factors like age, exposure at work to polycyclic hydrocarbons and the number of sister-chromatid exchanges in lymphocytes in the first sampling was significantly survival-related in the multivariate analysis.Conclusion. We determined that only three of the analyzed variables have an important effect on survival time when it comes to high-grade glioma patients. 2024 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84378930007 https://www.redalyc.org/journal/843/84378930007/ https://www.redalyc.org/journal/843/84378930007/html/ https://www.redalyc.org/journal/843/84378930007/84378930007.epub https://www.redalyc.org/journal/843/84378930007/movil 10.7705/biomedica.6742 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.2 Vol.44 |
| format | Artículo científico |
| id | redalyc_84378930007 |
| institution | Redalyc |
| language | en |
| publishDate | 2024 |
| publisher | Instituto Nacional de Salud |
| spellingShingle | Survival analysis and associated factors of high-grade glioma patients Lina Marcela Barrera Medicina Glioma Kaplan genetics prognosis risk factors Survival analysis and associated factors of high-grade glioma patients Lina Marcela Barrera León Darío Ortiz Hugo de Jesús Grisales Mauricio Camargo Medicina Glioma Kaplan genetics prognosis risk factors Introduction. High-grade gliomas are the most common primary brain tumors in adults, and they usually have a quick fatal course. Average survival is 18 months, mainly, because of tumor resistance to Stupp protocol.Objective. To determine high-grade glioma patient survival and the effect of persuasion variables on survival.Materials and methods. We conducted a longitudinal descriptive study in which 80 untreated recently diagnosed high-grade glioma patients participated. A survey was conducted regarding their exposure to some risk factors, degree of genetic instability in peripheral blood using micronucleus quantification on binuclear lymphocytes, micronuclei in reticulocytes and sister-chromatid exchanges in lymphocytes. In the statistical analysis, this study constructed life tables, used the Kaplan-Meier, and the log-rank test, and in the multivariate analysis, a Cox proportional hazards model was constructed. Results. Eighty patients' clinical, demographic and lifestyle characteristics were analyzed, as well as their survival rates and the average survival time is 784 days (interquartile range: 928). Factors like age, exposure at work to polycyclic hydrocarbons and the number of sister-chromatid exchanges in lymphocytes in the first sampling was significantly survival-related in the multivariate analysis.Conclusion. We determined that only three of the analyzed variables have an important effect on survival time when it comes to high-grade glioma patients. 2024 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84378930007 https://www.redalyc.org/journal/843/84378930007/ https://www.redalyc.org/journal/843/84378930007/html/ https://www.redalyc.org/journal/843/84378930007/84378930007.epub https://www.redalyc.org/journal/843/84378930007/movil 10.7705/biomedica.6742 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.2 Vol.44 |
| title | Survival analysis and associated factors of high-grade glioma patients |
| topic | Medicina Glioma Kaplan genetics prognosis risk factors |
| url | https://www.redalyc.org/articulo.oa?id=84378930007 https://www.redalyc.org/journal/843/84378930007/ https://www.redalyc.org/journal/843/84378930007/html/ https://www.redalyc.org/journal/843/84378930007/84378930007.epub https://www.redalyc.org/journal/843/84378930007/movil |