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Instituto Nacional de Salud
2024
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| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=84379006017 https://www.redalyc.org/journal/843/84379006017/ https://www.redalyc.org/journal/843/84379006017/html/ https://www.redalyc.org/journal/843/84379006017/84379006017.epub https://www.redalyc.org/journal/843/84379006017/movil |
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- Diabetes mellitus in patients with heart failure and effect modification of risk factors for short-term mortality: An observational study from the Registro Colombiano de Falla Cardíaca (RECOLFACA) Luis Eduardo Echeverría Clara Saldarriaga Sebastián Campbell-Quintero Lisbeth Natalia Morales-Rodríguez Juan David López-Ponce de León Andrés Felipe Buitrago Erika Martínez-Carreño Jorge Alberto Sandoval-Luna Alexis Llamas Gustavo Adolfo Moreno-Silgado Julián Vanegas-Eljach Nelson Eduardo Murillo-Benítez Ricardo Gómez-Paláu Alex Arnulfo Rivera-Toquica Juan Esteban Gómez-Mesa Medicina type 2 Colombia mortality risk factors heart failure Introduction Heart failure and type 2 diabetes mellitus are critical public health issues. Objective To characterize the risk factors for mortality in patients with heart failure and type 2 diabetes mellitus from a large registry in Colombia and to evaluate the potential effect modifications by type 2 diabetes mellitus over other risk factors.Materials and methods Heart failure patients with and without type 2 diabetes mellitus enrolled in the Registro Colombiano de Falla Cardíaca (RECOLFACA) were included.RECOLFACA enrolled adult patients with heart failure diagnosis from 60 medical centers in Colombia during 2017-2019. The primary outcome was all-cause mortality. Survival analysis was performed using adjusted Cox proportional hazard models.Results A total of 2514 patients were included, and the prevalence of type 2 diabetes mellitus was 24.7% (n = 620). We found seven independent predictors of short-term mortality for the general cohort, chronic obstructive pulmonary disease, sinus rhythm, triple therapy, nitrates use, statins use, anemia, and hyperkalemia. In the type 2 diabetes mellitus group, only the left ventricle diastolic diameter was an independent mortality predictor (HR = 0.96; 95% CI: 0.93-0.98). There was no evidence of effect modification by type 2 diabetes mellitus on the relationship between any independent predictors and all-cause mortality.However, a significant effect modification by type 2 diabetes mellitus between smoking and mortality was observed.Conclusions Patients with type 2 diabetes mellitus had higher mortality risk. Our results also suggest that type 2 diabetes mellitus diagnosis does not modify the effect of the independent risk factors for mortality in heart failure evaluated. However, type 2 diabetes mellitus significantly modify the risk relation between mortality and smoking in patients with heart failure. 2024 artículo científico 0120-4157 https://www.redalyc.org/articulo.oa?id=84379006017 https://www.redalyc.org/journal/843/84379006017/ https://www.redalyc.org/journal/843/84379006017/html/ https://www.redalyc.org/journal/843/84379006017/84379006017.epub https://www.redalyc.org/journal/843/84379006017/movil 10.7705/biomedica.6951 en http://www.redalyc.org/revista.oa?id=843 Biomédica application/pdf Instituto Nacional de Salud Biomédica (Colombia) Num.1 Vol.44