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| Format: | Artículo científico |
| Language: | en |
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Universidad de Buenos Aires
2006
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| Online Access: | https://www.redalyc.org/articulo.oa?id=86350304 |
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| _version_ | 1866811888223911936 |
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| author | Pablo Francisco Argibay |
| author_facet | Pablo Francisco Argibay |
| contents | La regeneración del sistema nervioso central: Cambios de paradigma y medicina regenerativa Pablo Francisco Argibay Química Contrary to the traditional view that neurogenesis in the adult brain ceases during prenataldevelopment, it is now well established that the hippocampus and the subventricular zonecontinues to produce neurons in the adulthood in several species, including humans. Moreover,accumulating evidence from anatomical, electrophysiological and immunohistochemical studiesindicates that the newly generated cells become integrated into the circuitry of the hippocampalsystem. There remains, however, considerable controversy over the functional significance ofthese new cells. On the other hand, investigation of the molecular and cellular events sustainingintrinsic brain-repair mechanisms and a better understanding of why they fail over time in chronicdisorders might, therefore, provide an attractive working hypothesis within which to develop newand efficacious therapies for neurological diseases. The review here presented intents todescribe the current knowledge regarding the process of neurogénesis, their mechanisms, andthe potential role for newly generated neurons in terms of neuroplasticity and regenerativemedicine. 2006 artículo científico 1666-7948 https://www.redalyc.org/articulo.oa?id=86350304 en http://www.redalyc.org/revista.oa?id=863 Química Viva application/pdf Universidad de Buenos Aires Química Viva (Argentina) Num.3 Vol.5 |
| format | Artículo científico |
| id | redalyc_86350304 |
| language | en |
| publishDate | 2006 |
| publisher | Universidad de Buenos Aires |
| spellingShingle | La regeneración del sistema nervioso central: Cambios de paradigma y medicina regenerativa Pablo Francisco Argibay Química La regeneración del sistema nervioso central: Cambios de paradigma y medicina regenerativa Pablo Francisco Argibay Química Contrary to the traditional view that neurogenesis in the adult brain ceases during prenataldevelopment, it is now well established that the hippocampus and the subventricular zonecontinues to produce neurons in the adulthood in several species, including humans. Moreover,accumulating evidence from anatomical, electrophysiological and immunohistochemical studiesindicates that the newly generated cells become integrated into the circuitry of the hippocampalsystem. There remains, however, considerable controversy over the functional significance ofthese new cells. On the other hand, investigation of the molecular and cellular events sustainingintrinsic brain-repair mechanisms and a better understanding of why they fail over time in chronicdisorders might, therefore, provide an attractive working hypothesis within which to develop newand efficacious therapies for neurological diseases. The review here presented intents todescribe the current knowledge regarding the process of neurogénesis, their mechanisms, andthe potential role for newly generated neurons in terms of neuroplasticity and regenerativemedicine. 2006 artículo científico 1666-7948 https://www.redalyc.org/articulo.oa?id=86350304 en http://www.redalyc.org/revista.oa?id=863 Química Viva application/pdf Universidad de Buenos Aires Química Viva (Argentina) Num.3 Vol.5 |
| title | La regeneración del sistema nervioso central: Cambios de paradigma y medicina regenerativa |
| topic | Química |
| url | https://www.redalyc.org/articulo.oa?id=86350304 |