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Bibliographic Details
Main Author:	A. Bocanegra Diaz
Format:	Artículo científico
Language:	es
Published:	Universidad de Pamplona 2006
Subjects:	Química anti neoplásico metotrexato anticancerígeno complejo cfmdmetotrexato
Online Access:	https://www.redalyc.org/articulo.oa?id=90340203
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Estudio por espectroscopia de absorción en la región infrarroja del complejo de inclusión de un compuesto antineoplásico (metotrexato) en un cargador de fármacos magnéticamente dirigido A. Bocanegra Diaz R. Ochoa Bejarano Química anti neoplásico metotrexato anticancerígeno complejo cfmdmetotrexato Se realizó el estudio de los espectros vibracionales en la región infrarroja de la betaciclodextrina, el metotrexato (MTX), el complejo de inclusión metotrexato betaciclodextrina, el cargador de fármacos magnéticamente dirigible (CFMD) y el productode la reacción MTX-CFMD. Los resultados obtenidos indican que el metotrexato seincluye profundamente en la beta ciclodextrina, formando un complejo de inclusión1:2. En el cargador de fármacos magnéticamente dirigible (CFMD) se incluyeparcialmente y forma dos tipos de complejos 1:1. Uno de los complejos formadosincluye los anillos de pteridina en la cavidad en tanto que el otro los deja por fuera.Esta combinación de complejos MTX:CFMD puede resultar altamente benéfica para el tratamiento de enfermedades localizadas que respondan a la quimioterapia conMTX, pues se tiene la posibilidad de un tratamiento rápido, localizado y a la vez deacción controlada. 2006 artículo científico 0120-4211 https://www.redalyc.org/articulo.oa?id=90340203 es http://www.redalyc.org/revista.oa?id=903 Bistua: Revista de la Facultad de Ciencias Básicas application/pdf Universidad de Pamplona Bistua: Revista de la Facultad de Ciencias Básicas (Colombia) Num.2 Vol.4

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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