Reference Values for Electrolytes and Blood Gases in Wistar Rats with Permanent Cerebral Ischemia: The Effect of Treatment with Glycine on Gasometry and Electrolytes
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| Format: | Artículo científico |
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Universidad del Zulia
2011
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| author | Rebeca Uribe-Escamilla |
| author_facet | Rebeca Uribe-Escamilla |
| contents | Reference Values for Electrolytes and Blood Gases in Wistar Rats with Permanent Cerebral Ischemia: The Effect of Treatment with Glycine on Gasometry and Electrolytes Rebeca Uribe-Escamilla Pedro Sánchez Aparicio Alejandro Córdova Izquierdo Alfonso Alfaro-Rodríguez Agrociencias glycine ischemia gasometry electrolytes Cerebral ischemia is a common neurological condition in people with hypoxia. Glycine is an inhibitory neurotransmitter that could protect neurons from hypoxia-induced toxicity. The aim of this study was to obtain reference values on gasometry and electrolytes and evaluate the effect of treatment with glycine on gasometry and electrolytes inWistar rats with ischemic brain injury. Fifteen male Wistar rats (mean body weight, 340 g) were randomly allocated to the following three groups: G0 rats underwent permanent left carotid occlusion and received treatment with a placebo; G1 rats underwent a permanent left carotid occlusion and received treatment with glycine i.p 40mMol/kg post-surgery; G2 rats with surgery received treatment with glycine i.p 40mMol/kg 5 days pre-surgery. Blood was obtained by cardiocentesis to determine reference values for electrolytes and blood gases. The results show some major alterations in acid base and electrolytes in G0, and statistical significance in glucose levels for G1,2. Glycine administered toWistar rats with permanent left carotid occlusion limited changes in the acid base and electrolytes and increased glucose levels from the beginning of the ischemia, initiating brain protection by altering the cascade of events that lead to cellular death. 2011 artículo científico 1317-2255 https://www.redalyc.org/articulo.oa?id=90421972007 en http://www.redalyc.org/revista.oa?id=904 Multiciencias application/pdf Universidad del Zulia Multiciencias (República Bolivariana de Venezuela) Num.4 Vol.11 |
| format | Artículo científico |
| id | redalyc_90421972007 |
| institution | Redalyc |
| language | en |
| publishDate | 2011 |
| publisher | Universidad del Zulia |
| spellingShingle | Reference Values for Electrolytes and Blood Gases in Wistar Rats with Permanent Cerebral Ischemia: The Effect of Treatment with Glycine on Gasometry and Electrolytes Rebeca Uribe-Escamilla Agrociencias glycine ischemia gasometry electrolytes Reference Values for Electrolytes and Blood Gases in Wistar Rats with Permanent Cerebral Ischemia: The Effect of Treatment with Glycine on Gasometry and Electrolytes Rebeca Uribe-Escamilla Pedro Sánchez Aparicio Alejandro Córdova Izquierdo Alfonso Alfaro-Rodríguez Agrociencias glycine ischemia gasometry electrolytes Cerebral ischemia is a common neurological condition in people with hypoxia. Glycine is an inhibitory neurotransmitter that could protect neurons from hypoxia-induced toxicity. The aim of this study was to obtain reference values on gasometry and electrolytes and evaluate the effect of treatment with glycine on gasometry and electrolytes inWistar rats with ischemic brain injury. Fifteen male Wistar rats (mean body weight, 340 g) were randomly allocated to the following three groups: G0 rats underwent permanent left carotid occlusion and received treatment with a placebo; G1 rats underwent a permanent left carotid occlusion and received treatment with glycine i.p 40mMol/kg post-surgery; G2 rats with surgery received treatment with glycine i.p 40mMol/kg 5 days pre-surgery. Blood was obtained by cardiocentesis to determine reference values for electrolytes and blood gases. The results show some major alterations in acid base and electrolytes in G0, and statistical significance in glucose levels for G1,2. Glycine administered toWistar rats with permanent left carotid occlusion limited changes in the acid base and electrolytes and increased glucose levels from the beginning of the ischemia, initiating brain protection by altering the cascade of events that lead to cellular death. 2011 artículo científico 1317-2255 https://www.redalyc.org/articulo.oa?id=90421972007 en http://www.redalyc.org/revista.oa?id=904 Multiciencias application/pdf Universidad del Zulia Multiciencias (República Bolivariana de Venezuela) Num.4 Vol.11 |
| title | Reference Values for Electrolytes and Blood Gases in Wistar Rats with Permanent Cerebral Ischemia: The Effect of Treatment with Glycine on Gasometry and Electrolytes |
| topic | Agrociencias glycine ischemia gasometry electrolytes |
| url | https://www.redalyc.org/articulo.oa?id=90421972007 |