Theoretical basis for the study of the effect of base composition on DNA melting
Fuente:
Universidad Nacional Autónoma de México
Resumen: We extend the ideas used to describe the glass transition in strong glasses employing the stochastic matrix method, giving a theoretical framework for the study of the configurational changes and the melting temperature of DNA. Our theoretical model enables a systematic study of the melting...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Artículo de Investigación |
| Language: | English |
| Published: |
Sociedad Mexicana de Física, A.C.
2004
Universidad Nacional Autónoma de México; Facultad de Ciencias |
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Resumen: We extend the ideas used to describe the glass transition in strong glasses employing the stochastic matrix method, giving a theoretical framework for the study of the configurational changes and the melting temperature of DNA. Our theoretical model enables a systematic study of the melting transition and the melting temperature dependence on the sequence differences in vertical stacking. Taking into account the fractional composition in a single strand, exact analytic results are given for the fraction of bonds intact and denatured at a particular temperature. This method is applicable to long DNA as well as RNA. |
|---|