Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract
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2026
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| author | Yunjung Lee Youngjoon Kim Seokjun Kwon Ok Kyu Park Gyeong Ho Min Jinyoung Chu Yubeen Kim Johyun Yoon Hyochul Lee Hojun Kim Min Soh Nohyun Lee Hojeong Jeon Yu‐Chan Kim Junchul Kim Ki Baek Yeo Seung Hong Choi Sang Ho Jun Yuhan Lee Taeghwan Hyeon Sang‐woo Lee Sang Ihn Han |
| author_facet | Yunjung Lee Youngjoon Kim Seokjun Kwon Ok Kyu Park Gyeong Ho Min Jinyoung Chu Yubeen Kim Johyun Yoon Hyochul Lee Hojun Kim Min Soh Nohyun Lee Hojeong Jeon Yu‐Chan Kim Junchul Kim Ki Baek Yeo Seung Hong Choi Sang Ho Jun Yuhan Lee Taeghwan Hyeon Sang‐woo Lee Sang Ihn Han Yunjung Lee Youngjoon Kim Seokjun Kwon Ok Kyu Park Gyeong Ho Min Jinyoung Chu Yubeen Kim Johyun Yoon Hyochul Lee Hojun Kim Min Soh Nohyun Lee Hojeong Jeon Yu‐Chan Kim Junchul Kim Ki Baek Yeo Seung Hong Choi Sang Ho Jun Yuhan Lee Taeghwan Hyeon Sang‐woo Lee Sang Ihn Han |
| collection | Wiley Open Access |
| contents | Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract Yunjung Lee Youngjoon Kim Seokjun Kwon Ok Kyu Park Gyeong Ho Min Jinyoung Chu Yubeen Kim Johyun Yoon Hyochul Lee Hojun Kim Min Soh Nohyun Lee Hojeong Jeon Yu‐Chan Kim Junchul Kim Ki Baek Yeo Seung Hong Choi Sang Ho Jun Yuhan Lee Taeghwan Hyeon Sang‐woo Lee Sang Ihn Han Advanced Materials ABSTRACT Oral delivery of therapeutic nanoparticles offers a non‐invasive approach for treating gastrointestinal diseases, but achieving localized and sustained mucosal exposure while avoiding systemic toxicity remains a major challenge. Here, a Sucralfate‐based oral formulation is developed that incorporates therapeutic nanoparticles and transforms into a paste‐like coacervate upon contact with intestinal fluid, uniformly coating the entire gastrointestinal tract within 6 h, and clearing through fecal transit by 12 h. Systematic investigation shows that nanoparticle hydrophobicity is essential for stable incorporation into Sucralfate‐based formulation, supporting compatibility with a wide range of nanoparticle types. The incorporated nanoparticles are stabilized by strong non‐covalent interactions, which limit gastric leaching and reduce cellular uptake by 0.044% compared with PEGylated nanoparticles. As a representative example, antioxidant cerium oxide nanoparticles are tested in two distinct oxidative stress‐related models of intestinal injury, including immune‐mediated colitis and radiation‐induced enteropathy. In DSS colitis, our system reduced weight loss from 17.2% to 2.2% and restored colon structure and oxidative‐stress injury. In radiation‐induced enteropathy, our system attenuated weight loss from 25.5% to 11.4%, doubled villus length, and markedly enhanced epithelial regeneration. The formulation also accommodates nanoparticles with imaging capability, demonstrating versatility for both therapeutic and diagnostic applications in gastrointestinal diseases. 10.1002/adma.202514708 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/adma.202514708 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_adma_202514708 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract Yunjung Lee Youngjoon Kim Seokjun Kwon Ok Kyu Park Gyeong Ho Min Jinyoung Chu Yubeen Kim Johyun Yoon Hyochul Lee Hojun Kim Min Soh Nohyun Lee Hojeong Jeon Yu‐Chan Kim Junchul Kim Ki Baek Yeo Seung Hong Choi Sang Ho Jun Yuhan Lee Taeghwan Hyeon Sang‐woo Lee Sang Ihn Han Advanced Materials Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract Yunjung Lee Youngjoon Kim Seokjun Kwon Ok Kyu Park Gyeong Ho Min Jinyoung Chu Yubeen Kim Johyun Yoon Hyochul Lee Hojun Kim Min Soh Nohyun Lee Hojeong Jeon Yu‐Chan Kim Junchul Kim Ki Baek Yeo Seung Hong Choi Sang Ho Jun Yuhan Lee Taeghwan Hyeon Sang‐woo Lee Sang Ihn Han Advanced Materials ABSTRACT Oral delivery of therapeutic nanoparticles offers a non‐invasive approach for treating gastrointestinal diseases, but achieving localized and sustained mucosal exposure while avoiding systemic toxicity remains a major challenge. Here, a Sucralfate‐based oral formulation is developed that incorporates therapeutic nanoparticles and transforms into a paste‐like coacervate upon contact with intestinal fluid, uniformly coating the entire gastrointestinal tract within 6 h, and clearing through fecal transit by 12 h. Systematic investigation shows that nanoparticle hydrophobicity is essential for stable incorporation into Sucralfate‐based formulation, supporting compatibility with a wide range of nanoparticle types. The incorporated nanoparticles are stabilized by strong non‐covalent interactions, which limit gastric leaching and reduce cellular uptake by 0.044% compared with PEGylated nanoparticles. As a representative example, antioxidant cerium oxide nanoparticles are tested in two distinct oxidative stress‐related models of intestinal injury, including immune‐mediated colitis and radiation‐induced enteropathy. In DSS colitis, our system reduced weight loss from 17.2% to 2.2% and restored colon structure and oxidative‐stress injury. In radiation‐induced enteropathy, our system attenuated weight loss from 25.5% to 11.4%, doubled villus length, and markedly enhanced epithelial regeneration. The formulation also accommodates nanoparticles with imaging capability, demonstrating versatility for both therapeutic and diagnostic applications in gastrointestinal diseases. 10.1002/adma.202514708 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract |
| topic | Advanced Materials |
| url | https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202514708 |