Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy
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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2026
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| author | Yang Wang Siyuan Ma Yan Zhao Jinyan Hu Zhenlin Zhang Hongjing Dou Ping Li Dengyu Pan Bijiang Geng Longxiang Shen |
| author_facet | Yang Wang Siyuan Ma Yan Zhao Jinyan Hu Zhenlin Zhang Hongjing Dou Ping Li Dengyu Pan Bijiang Geng Longxiang Shen Yang Wang Siyuan Ma Yan Zhao Jinyan Hu Zhenlin Zhang Hongjing Dou Ping Li Dengyu Pan Bijiang Geng Longxiang Shen |
| collection | Wiley Open Access |
| contents | Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy Yang Wang Siyuan Ma Yan Zhao Jinyan Hu Zhenlin Zhang Hongjing Dou Ping Li Dengyu Pan Bijiang Geng Longxiang Shen Advanced Materials ABSTRACT Osteomyelitis remains a refractory orthopedic disease; it is urgent to develop osteomyelitis‐microenvironment‐responsive, dynamic‐crosslinked hydrogels that could fight infection, regulate inflammation, and accelerate bone repair simultaneously for on‐demand osteomyelitis therapy. Herein, we report an all‐in‐one hydrogel design based on a highly biocompatible, covalently interlinked, and multifunctional carbon dot (CD) platform for simultaneous regulation of antibacterial, anti‐inflammatory, and osteogenic activities while enabling bacteria‐specific and controllable release of CDs. To achieve this aim, CDs was significantly modified with two structural factors, i.e., catechol grafted at the edge and Se─Se bonds doped in the core, which play crucial roles in the precise regulation of their multiple functions for on‐demand osteomyelitis therapy. Dynamically crosslinked composite hydrogels with dissociable borate ester bonds were constructed by utilizing catechol‐functionalized Se‐doped CDs as a triple bioactive ingredient. The CD‐based composite hydrogels were demonstrated to enable near‐complete healing of bone defects in a MRSA‐induced osteomyelitis model. This work provides a paradigm for fabrication of dynamic‐crosslinked hydrogels from multifunctional CDs for on‐demand osteomyelitis therapy. 10.1002/adma.73080 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/adma.73080 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_adma_73080 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy Yang Wang Siyuan Ma Yan Zhao Jinyan Hu Zhenlin Zhang Hongjing Dou Ping Li Dengyu Pan Bijiang Geng Longxiang Shen Advanced Materials Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy Yang Wang Siyuan Ma Yan Zhao Jinyan Hu Zhenlin Zhang Hongjing Dou Ping Li Dengyu Pan Bijiang Geng Longxiang Shen Advanced Materials ABSTRACT Osteomyelitis remains a refractory orthopedic disease; it is urgent to develop osteomyelitis‐microenvironment‐responsive, dynamic‐crosslinked hydrogels that could fight infection, regulate inflammation, and accelerate bone repair simultaneously for on‐demand osteomyelitis therapy. Herein, we report an all‐in‐one hydrogel design based on a highly biocompatible, covalently interlinked, and multifunctional carbon dot (CD) platform for simultaneous regulation of antibacterial, anti‐inflammatory, and osteogenic activities while enabling bacteria‐specific and controllable release of CDs. To achieve this aim, CDs was significantly modified with two structural factors, i.e., catechol grafted at the edge and Se─Se bonds doped in the core, which play crucial roles in the precise regulation of their multiple functions for on‐demand osteomyelitis therapy. Dynamically crosslinked composite hydrogels with dissociable borate ester bonds were constructed by utilizing catechol‐functionalized Se‐doped CDs as a triple bioactive ingredient. The CD‐based composite hydrogels were demonstrated to enable near‐complete healing of bone defects in a MRSA‐induced osteomyelitis model. This work provides a paradigm for fabrication of dynamic‐crosslinked hydrogels from multifunctional CDs for on‐demand osteomyelitis therapy. 10.1002/adma.73080 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy |
| topic | Advanced Materials |
| url | https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.73080 |