The Landscape of Smart Biomaterial‐Based Hydrogen Therapy
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Wiley Open Access
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| Format: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867006985643229185 |
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| author | Min Xu Gege Wu Qing You Xiaoyuan Chen |
| author_facet | Min Xu Gege Wu Qing You Xiaoyuan Chen Min Xu Gege Wu Qing You Xiaoyuan Chen |
| collection | Wiley Open Access |
| contents | The Landscape of Smart Biomaterial‐Based Hydrogen Therapy Min Xu Gege Wu Qing You Xiaoyuan Chen Advanced Science AbstractHydrogen (H2) therapy is an emerging, novel, and safe therapeutic modality that uses molecular hydrogen for effective treatment. However, the impact of H2 therapy is limited because hydrogen molecules predominantly depend on the systemic administration of H2 gas, which cannot accumulate at the lesion site with high concentration, thus leading to limited targeting and utilization. Biomaterials are developed to specifically deliver H2 and control its release. In this review, the development process, stimuli‐responsive release strategies, and potential therapeutic mechanisms of biomaterial‐based H2 therapy are summarized. H2 therapy. Specifically, the produced H2 from biomaterials not only can scavenge free radicals, such as reactive oxygen species (ROS) and lipid peroxidation (LPO), but also can inhibit the danger factors of initiating diseases, including pro‐inflammatory cytokines, adenosine triphosphate (ATP), and heat shock protein (HSP). In addition, the released H2 can further act as signal molecules to regulate key pathways for disease treatment. The current opportunities and challenges of H2‐based therapy are discussed, and the future research directions of biomaterial‐based H2 therapy for clinical applications are emphasized. 10.1002/advs.202401310 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/advs.202401310 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_advs_202401310 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The Landscape of Smart Biomaterial‐Based Hydrogen Therapy Min Xu Gege Wu Qing You Xiaoyuan Chen Advanced Science The Landscape of Smart Biomaterial‐Based Hydrogen Therapy Min Xu Gege Wu Qing You Xiaoyuan Chen Advanced Science AbstractHydrogen (H2) therapy is an emerging, novel, and safe therapeutic modality that uses molecular hydrogen for effective treatment. However, the impact of H2 therapy is limited because hydrogen molecules predominantly depend on the systemic administration of H2 gas, which cannot accumulate at the lesion site with high concentration, thus leading to limited targeting and utilization. Biomaterials are developed to specifically deliver H2 and control its release. In this review, the development process, stimuli‐responsive release strategies, and potential therapeutic mechanisms of biomaterial‐based H2 therapy are summarized. H2 therapy. Specifically, the produced H2 from biomaterials not only can scavenge free radicals, such as reactive oxygen species (ROS) and lipid peroxidation (LPO), but also can inhibit the danger factors of initiating diseases, including pro‐inflammatory cytokines, adenosine triphosphate (ATP), and heat shock protein (HSP). In addition, the released H2 can further act as signal molecules to regulate key pathways for disease treatment. The current opportunities and challenges of H2‐based therapy are discussed, and the future research directions of biomaterial‐based H2 therapy for clinical applications are emphasized. 10.1002/advs.202401310 http://creativecommons.org/licenses/by/4.0/ |
| title | The Landscape of Smart Biomaterial‐Based Hydrogen Therapy |
| topic | Advanced Science |
| url | https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202401310 |