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Main Authors:	Alexey V. Yaremenko, Roman O. Melikov, Nadezhda A. Pechnikova, Iaroslav B. Belyaev, Alina Ringaci, Tamara V. Yaremenko, Aziz B. Mirkasymov, Alexandr A. Tamgin, Vladislav I. Rodionov, Sofya M. Dolotova, Grigory A. Plisko, Evgeny D. Semivelichenko, Anna S. Rogova, Albert R. Muslimov, Arina S. Ivkina, Dmitry Yu. Ivkin, Valery P. Erichev, Sergey M. Deyev, Sergey E. Avetisov, Yongjiang Li, Hai‐Jun Liu, Ivan V. Zelepukin
Format:	Artículo Open Access
Published:	Wiley 2024
Subjects:	Aggregate
Online Access:	https://onlinelibrary.wiley.com/doi/10.1002/agt2.586
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Modification of contact lenses via metal‐organic frameworks for glaucoma treatment Alexey V. Yaremenko Roman O. Melikov Nadezhda A. Pechnikova Iaroslav B. Belyaev Alina Ringaci Tamara V. Yaremenko Aziz B. Mirkasymov Alexandr A. Tamgin Vladislav I. Rodionov Sofya M. Dolotova Grigory A. Plisko Evgeny D. Semivelichenko Anna S. Rogova Albert R. Muslimov Arina S. Ivkina Dmitry Yu. Ivkin Valery P. Erichev Sergey M. Deyev Sergey E. Avetisov Yongjiang Li Hai‐Jun Liu Ivan V. Zelepukin Aggregate AbstractThe prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal‐organic frameworks with sustained release of brimonidine for prolonged glaucoma treatment. Various metal‐organic frameworks were screened for their attachment to lenses, loading with brimonidine, and drug‐release properties. Optimized therapeutic ocular lenses conjugated with MIL‐101(Cr) frameworks maintain optical transparency and power. Coating of lenses with MIL‐101(Cr) nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the cornea. The hybrid lenses provided a 4.5‐fold better decrease in eye pressure, compared by area under the curve (AUC) value to a commercially available brimonidine tartrate solution. Therapeutic lenses did not induce any notable eye irritation or corneal damage in vivo. The newly developed hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases. 10.1002/agt2.586 http://creativecommons.org/licenses/by/4.0/

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// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

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