Development of Pyrimidine‐Substituted Schiff Base and Their Axially Silicon Phthalocyanines as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease Therapy
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2025
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| author | Ayse Aktas Kamiloglu Tayfun Arslan Askın Tekin Halit Kantekin |
| author_facet | Ayse Aktas Kamiloglu Tayfun Arslan Askın Tekin Halit Kantekin Ayse Aktas Kamiloglu Tayfun Arslan Askın Tekin Halit Kantekin |
| collection | Wiley Open Access |
| contents | Development of Pyrimidine‐Substituted Schiff Base and Their Axially Silicon Phthalocyanines as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease Therapy Ayse Aktas Kamiloglu Tayfun Arslan Askın Tekin Halit Kantekin Applied Organometallic Chemistry ABSTRACTIn this study, axially substituted silicon (IV) phthalocyanine complexes containing pyrimidine‐substituted Schiff bases were synthesized and characterized. The Schiff bases (Pyr‐1 and Pyr‐2) were synthesized through a condensation reaction between pyrimidine derivatives and appropriate aldehydes, followed by their coordination with silicon (IV) to form the corresponding phthalocyanine complexes (Pyr‐1‐SiPc and Pyr‐2‐SiPc). The synthesized Schiff bases (Pyr‐1 and Pyr‐2) and silicon (IV) phthalocyanine derivatives (Pyr‐1‐SiPc and Pyr‐2‐SiPc) were subsequently tested in vivo for their inhibitory effect on the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). A substantial number of these compounds exhibited pronounced inhibitory activity against both enzymes. Notably, among the phthalocyanines and their precursor compounds, the most intriguing were identified as submicromolar selective inhibitors of AChE and BChE, with IC50 values of 4.26 μM and 6.46 μM, respectively. 10.1002/aoc.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/aoc.70113 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_aoc_70113 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Development of Pyrimidine‐Substituted Schiff Base and Their Axially Silicon Phthalocyanines as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease Therapy Ayse Aktas Kamiloglu Tayfun Arslan Askın Tekin Halit Kantekin Applied Organometallic Chemistry Development of Pyrimidine‐Substituted Schiff Base and Their Axially Silicon Phthalocyanines as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease Therapy Ayse Aktas Kamiloglu Tayfun Arslan Askın Tekin Halit Kantekin Applied Organometallic Chemistry ABSTRACTIn this study, axially substituted silicon (IV) phthalocyanine complexes containing pyrimidine‐substituted Schiff bases were synthesized and characterized. The Schiff bases (Pyr‐1 and Pyr‐2) were synthesized through a condensation reaction between pyrimidine derivatives and appropriate aldehydes, followed by their coordination with silicon (IV) to form the corresponding phthalocyanine complexes (Pyr‐1‐SiPc and Pyr‐2‐SiPc). The synthesized Schiff bases (Pyr‐1 and Pyr‐2) and silicon (IV) phthalocyanine derivatives (Pyr‐1‐SiPc and Pyr‐2‐SiPc) were subsequently tested in vivo for their inhibitory effect on the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). A substantial number of these compounds exhibited pronounced inhibitory activity against both enzymes. Notably, among the phthalocyanines and their precursor compounds, the most intriguing were identified as submicromolar selective inhibitors of AChE and BChE, with IC50 values of 4.26 μM and 6.46 μM, respectively. 10.1002/aoc.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Development of Pyrimidine‐Substituted Schiff Base and Their Axially Silicon Phthalocyanines as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease Therapy |
| topic | Applied Organometallic Chemistry |
| url | https://onlinelibrary.wiley.com/doi/10.1002/aoc.70113 |