Reduction of Carboxamides Into Amines Catalyzed by La[NH‐2,6‐iPr2‐4‐FcC6H2]3/HBpin
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| Format: | Artículo Open Access |
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2024
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| _version_ | 1867013924032872449 |
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| author | Qiujin Ye Yukun Wang Jue Chen Yunjie Luo |
| author_facet | Qiujin Ye Yukun Wang Jue Chen Yunjie Luo Qiujin Ye Yukun Wang Jue Chen Yunjie Luo |
| collection | Wiley Open Access |
| contents | Reduction of Carboxamides Into Amines Catalyzed by La[NH‐2,6‐iPr2‐4‐FcC6H2]3/HBpin Qiujin Ye Yukun Wang Jue Chen Yunjie Luo Applied Organometallic Chemistry ABSTRACTReduction of carboxamides is an efficient approach to obtain the corresponding amines, albeit it is one of the most problematic. In this work, by use of pinacolborane (HBpin) as a reductant, the rare‐earth metal tris (arylamido) complex supported by a ferrocenyl‐modified arylamido ligand La[NH‐2,6‐iPr2‐4‐FcC6H2]3 was employed as a precatalyst for primary and secondary amide reductions. This catalyst system exhibited high activity toward hydroborative reduction of amides to amines under mild conditions, as well good tolerance for heteroatoms and functional groups in the reduction. A lanthanide hydride was experimentally verified as the active species and the reduction mechanism was proposed. 10.1002/aoc.7739 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/aoc.7739 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_aoc_7739 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Reduction of Carboxamides Into Amines Catalyzed by La[NH‐2,6‐iPr2‐4‐FcC6H2]3/HBpin Qiujin Ye Yukun Wang Jue Chen Yunjie Luo Applied Organometallic Chemistry Reduction of Carboxamides Into Amines Catalyzed by La[NH‐2,6‐iPr2‐4‐FcC6H2]3/HBpin Qiujin Ye Yukun Wang Jue Chen Yunjie Luo Applied Organometallic Chemistry ABSTRACTReduction of carboxamides is an efficient approach to obtain the corresponding amines, albeit it is one of the most problematic. In this work, by use of pinacolborane (HBpin) as a reductant, the rare‐earth metal tris (arylamido) complex supported by a ferrocenyl‐modified arylamido ligand La[NH‐2,6‐iPr2‐4‐FcC6H2]3 was employed as a precatalyst for primary and secondary amide reductions. This catalyst system exhibited high activity toward hydroborative reduction of amides to amines under mild conditions, as well good tolerance for heteroatoms and functional groups in the reduction. A lanthanide hydride was experimentally verified as the active species and the reduction mechanism was proposed. 10.1002/aoc.7739 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Reduction of Carboxamides Into Amines Catalyzed by La[NH‐2,6‐iPr2‐4‐FcC6H2]3/HBpin |
| topic | Applied Organometallic Chemistry |
| url | https://onlinelibrary.wiley.com/doi/10.1002/aoc.7739 |