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| Main Authors: | , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/app.57549 |
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Table of Contents:
- Influence of Beta Tricalcium Phosphate Particles on In Vitro Material Degradation and Early Cell Attachment of MC3T3‐E1 Cells on Poly(3‐Hydroxybutyrate)/Poly(3‐Hydroxybutyrate‐Co‐4‐Hydroxybutyrate) Films Sabrina Kopf Elina Kylmäoja Dan Åkesson Maria Persson Mikael Skrifvars Journal of Applied Polymer Science ABSTRACTThe influence of beta‐tricalcium phosphate (ß‐TCP) particles on the early cell attachment of MC3T3‐E1 osteoblast precursor cells is investigated on a poly(3‐hydroxybutyrate)/poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) polymer blend. MC3T3‐E1 cells adhere to both polymer blends, with and without ß‐TCP. In both cases, the cells show a typical cell morphology and focal adhesions on the polymer surface. The ß‐TCP does not significantly improve the cell adhesion and hydrophilicity of the polymer films. Further, ß‐TCP does not alter the degradation behavior of the poly(3‐hydroxybutyrate)/poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) blend when exposed to phosphate buffered saline solution for up to 70 days. However, the results confirm that the polyhydroxyalkanoate blends used in this study are non‐cytotoxic and maintain structural integrity over time. These findings highlight the blend's promise for usage in long‐term biomedical applications, particularly in bone tissue engineering, because of their stability in isotonic medium. 10.1002/app.57549 http://creativecommons.org/licenses/by/4.0/