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| Main Authors: | , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Subjects: | |
| Online Access: | https://scijournals.onlinelibrary.wiley.com/doi/10.1002/bbb.70100 |
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Table of Contents:
- Insights from meta‐analysis for efficient docosahexaenoic acid production in thraustochytrids through advanced cultivation and fermentation strategies Jhiovana Cristielly Carrera Silva da Costa Lucas Araújo Guimarães Andre da Luz de Freitas Luciana Porto de Souza Vandenberghe Gilberto Vinícius de Melo Pereira Carlos Ricardo Soccol Hervé Louis Ghislain Rogez Biofuels, Bioproducts and Biorefining Abstract This systematic review examines strategies for docosahexaenoic acid (DHA) production by thraustochytrids, focusing on cultivation techniques, fermentation technologies, and carbon/nitrogen optimization to increase productivity. Among 169 eligible articles, the 100 most productive studies (0.7–10.3 g DHA L −1 per day) were analyzed. Quantitative variables like carbon/nitrogen concentrations, temperature, and aeration showed weak correlation with DHA productivity, while qualitative factors were more strongly associated. Artificially selected strains (4.25 ± 0.41 g DHA L −1 per day) were statistically superior to wild strains (2.71 ± 0.28 g DHA L −1 per day; P < 0.05) and were comparable with genetically modified strains (4.47 ± 0.87 g DHA L −1 per day; P = 0.81). Glucose (3.85 ± 0.3 g DHA L −1 per day) and glycerol (3.94 ± 1.1 g DHA L −1 per day) yielded the highest productivities among the carbon sources, with no significant difference between them ( P > 0.1). Continuous cultivation systems (7.25 ± 1.07 g DHA L −1 per day) and fed‐batch methods (4.44 ± 0.34 g DHA L −1 per day) yielded higher productivity than batch fermentation ( P < 0.005). The meta‐analysis indicates that combining advanced strains and fermentation systems increase DHA productivity. 10.1002/bbb.70100 http://creativecommons.org/licenses/by/4.0/