Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali Roeth, Berkan Kurt, Florian Kahles, Thea Laurentius, Cornelius Bollheimer, Julia C. Stingl, Katja S. Just |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2025
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
par: Marco Hoffmann, et autres
Publié: (2026)
par: Marco Hoffmann, et autres
Publié: (2026)
Food‐derived compounds for CYP‐phenotyping
par: Manuel Haschke
Publié: (2024)
par: Manuel Haschke
Publié: (2024)
Solanidine analysis during therapeutic drug monitoring revealed rare CYP2D6 poor metabolizer genotype: A case report
par: Elisabet Størset, et autres
Publié: (2025)
par: Elisabet Størset, et autres
Publié: (2025)
The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach
par: Judith Berres, et autres
Publié: (2026)
par: Judith Berres, et autres
Publié: (2026)
Impact of CYP2D6*2A, CYP2D6*4 and CYP3A5*3 genetic polymorphisms on Bisoprolol peak concentration and clinical response in acute coronary syndrome patients
par: Sherouk M. Okda, et autres
Publié: (2024)
par: Sherouk M. Okda, et autres
Publié: (2024)
Strategies employed and experiences associated with the implementation of pharmaceutical services and interventions in geriatric wards: A scoping review
par: Alan Maicon de Oliveira, et autres
Publié: (2024)
par: Alan Maicon de Oliveira, et autres
Publié: (2024)
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia
par: Fei‐Ran Zhang, et autres
Publié: (2025)
par: Fei‐Ran Zhang, et autres
Publié: (2025)
Alternative splicing with CYP3A4*22: Implications for the steroid‐tacrolimus drug interaction
par: Jana Stojanova, et autres
Publié: (2025)
par: Jana Stojanova, et autres
Publié: (2025)
Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing
par: István Pesti, et autres
Publié: (2025)
par: István Pesti, et autres
Publié: (2025)
Pharmacokinetics of asundexian with combined CYP3A and P‐gp inhibitors and an inducer: Target in vitro and in vivo studies
par: Friederike Kanefendt, et autres
Publié: (2024)
par: Friederike Kanefendt, et autres
Publié: (2024)
Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity
par: Akitomo Yokokawa, et autres
Publié: (2026)
par: Akitomo Yokokawa, et autres
Publié: (2026)
GNS561 (ezurpimtrostat), a small basic lipophilic molecule, prevents lupus phenotype in a pristane‐induced lupus mouse model
par: Eya Toumi, et autres
Publié: (2025)
par: Eya Toumi, et autres
Publié: (2025)
Navigating therapeutic challenges: Voriconazole pharmacokinetics and CYP2C19 genetic polymorphism—A case report and literature review
par: Sadaf Ahmer, et autres
Publié: (2025)
par: Sadaf Ahmer, et autres
Publié: (2025)
Opportunities of patient‐derived organoids in drug development
par: Antonia Büning, et autres
Publié: (2025)
par: Antonia Büning, et autres
Publié: (2025)
Evaluation of cytochrome P450 (CYP) induction using RT‐qPCR in exosomes isolated from plasma samples: Method development and qualification
par: Shengjie Xu, et autres
Publié: (2026)
par: Shengjie Xu, et autres
Publié: (2026)
Evaluation of the effect of CYP2D6 and OCT1 polymorphisms on the pharmacokinetics of tramadol: Implications for clinical safety and dose rationale in paediatric chronic pain
par: Paul Healy, et autres
Publié: (2024)
par: Paul Healy, et autres
Publié: (2024)
CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)
par: Cinzia Dello Russo, et autres
Publié: (2025)
par: Cinzia Dello Russo, et autres
Publié: (2025)
Induction of IL‐9‐producing CD8 + T cells by ascochlorin derivatives
par: Natsumi Imano, et autres
Publié: (2026)
par: Natsumi Imano, et autres
Publié: (2026)
From cradle to cane—(Dis)similarities between paediatric and geriatric clinical pharmacology: A commentary arising from the 2024 International Union of Basic and Clinical Pharmacology (IUPHAR) World Smart Medication Day
par: Karel Allegaert, et autres
Publié: (2025)
par: Karel Allegaert, et autres
Publié: (2025)
Vestibular modulation by stimulant derivatives in a pentameric ligand‐gated ion channel
par: Emelia Karlsson, et autres
Publié: (2025)
par: Emelia Karlsson, et autres
Publié: (2025)
Evaluation of the antihypertensive and antihyperlipidaemic effects of a pyrimidine derivative in preventing cardiometabolic risk
par: Baskar Aswinanand, et autres
Publié: (2026)
par: Baskar Aswinanand, et autres
Publié: (2026)
Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system
par: Mariana G. de Oliveira, et autres
Publié: (2026)
par: Mariana G. de Oliveira, et autres
Publié: (2026)
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages
par: Yue Ji, et autres
Publié: (2024)
par: Yue Ji, et autres
Publié: (2024)
Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery
par: Christian W. Gruber, et autres
Publié: (2025)
par: Christian W. Gruber, et autres
Publié: (2025)
Prescriptions of CYP3A4‐ and P‐gp inducers for patients on direct oral anticoagulants: Bridging the gap between epidemiology and patient management for optimal thromboembolic event prevention
par: Stephanie C. M. Wuyts, et autres
Publié: (2025)
par: Stephanie C. M. Wuyts, et autres
Publié: (2025)
Identification of new small molecules for selective inhibition of SERCA 1 in patient‐derived metastatic papillary thyroid cancer
par: Seok‐Mo Kim, et autres
Publié: (2025)
par: Seok‐Mo Kim, et autres
Publié: (2025)
Drug‐likeness evaluation and inhibitory mechanism of the emodin derivative on cardiac fibrosis based on metastasis‐associated protein 3
par: Heng Liu, et autres
Publié: (2025)
par: Heng Liu, et autres
Publié: (2025)
A novel marine‐derived mitophagy inducer ameliorates mitochondrial dysfunction and thermal hypersensitivity in paclitaxel‐induced peripheral neuropathy
par: Sangwoo Im, et autres
Publié: (2024)
par: Sangwoo Im, et autres
Publié: (2024)
Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending‐dose study in healthy young men
par: Christian Friedrich, et autres
Publié: (2024)
par: Christian Friedrich, et autres
Publié: (2024)
Comparative Effectiveness of Clopidogrel vs . Potent P2Y 12 Inhibitors in CYP2C19 Normal Metabolizers Following Percutaneous Coronary Intervention: A Real‐World Cohort Study
par: Hsing‐Yu Hsu, et autres
Publié: (2025)
par: Hsing‐Yu Hsu, et autres
Publié: (2025)
Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury
par: Inés Valencia, et autres
Publié: (2025)
par: Inés Valencia, et autres
Publié: (2025)
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish
par: Balasubramanian Haridevamuthu, et autres
Publié: (2024)
par: Balasubramanian Haridevamuthu, et autres
Publié: (2024)
Plasma 6β‐hydroxycortisol to cortisol ratio as a less invasive cytochrome P450 3A phenotyping method
par: Ryohei Hirano, et autres
Publié: (2024)
par: Ryohei Hirano, et autres
Publié: (2024)
Comment on ‘comparative effectiveness of clopidogrel vs. potent P2Y 12 inhibitors in CYP2C19 normal metabolizers following percutaneous coronary intervention: A real‐world cohort study’
par: Mohammad Rafi Shaik, et autres
Publié: (2026)
par: Mohammad Rafi Shaik, et autres
Publié: (2026)
Comparing regulatory guidance on risk minimization/mitigation and the Reporting recommendation Intended for pharmaceutical Risk Minimization Evaluation Studies checklist
par: Sonia Guleria, et autres
Publié: (2024)
par: Sonia Guleria, et autres
Publié: (2024)
Response to: Comment on ‘comparative effectiveness of clopidogrel vs . potent P2Y12 inhibitors in CYP2C19 normal metabolizers following percutaneous coronary intervention: A real‐world cohort study’
par: Hsing‐Yu Hsu, et autres
Publié: (2026)
par: Hsing‐Yu Hsu, et autres
Publié: (2026)
P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy
par: Jaideep Kesavan, et autres
Publié: (2025)
par: Jaideep Kesavan, et autres
Publié: (2025)
Activation of autophagy mediated by PI3K/Akt/mTOR signalling cascade alleviates impaired adipose‐derived stem cell osteogenesis in a diabetic microenvironment
par: Fangzhi Lou, et autres
Publié: (2025)
par: Fangzhi Lou, et autres
Publié: (2025)
Improving prescribing outcomes in undergraduate medical training
par: Chee Yeen Fung, et autres
Publié: (2024)
par: Chee Yeen Fung, et autres
Publié: (2024)
IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling
par: Sun‐Ae Park, et autres
Publié: (2025)
par: Sun‐Ae Park, et autres
Publié: (2025)
Documents similaires
-
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
par: Marco Hoffmann, et autres
Publié: (2026) -
Food‐derived compounds for CYP‐phenotyping
par: Manuel Haschke
Publié: (2024) -
Solanidine analysis during therapeutic drug monitoring revealed rare CYP2D6 poor metabolizer genotype: A case report
par: Elisabet Størset, et autres
Publié: (2025) -
The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach
par: Judith Berres, et autres
Publié: (2026) -
Impact of CYP2D6*2A, CYP2D6*4 and CYP3A5*3 genetic polymorphisms on Bisoprolol peak concentration and clinical response in acute coronary syndrome patients
par: Sherouk M. Okda, et autres
Publié: (2024)