Evaluation of the acute effects of single‐dose TPN171 on semen quality in healthy Chinese male volunteers
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | Yuzhuo Yang, Zhe Zhang, Lei Li, Zhicheng Jiang, Jiaxiang Juan, Huaqing Duan, Zhen Wang, Hui Jiang |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers
by: Lisanne K. A. Neijenhuis, et al.
Published: (2026)
by: Lisanne K. A. Neijenhuis, et al.
Published: (2026)
Effects on cerebral blood flow after single doses of the β2 agonist, clenbuterol, in healthy volunteers and patients with mild cognitive impairment or Parkinson's disease
by: Thomas Lodeweyckx, et al.
Published: (2024)
by: Thomas Lodeweyckx, et al.
Published: (2024)
Why do healthy volunteers participate in clinical trials?
by: Thijs van Iersel, et al.
Published: (2026)
by: Thijs van Iersel, et al.
Published: (2026)
Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies
by: Yuji Kumagai, et al.
Published: (2025)
by: Yuji Kumagai, et al.
Published: (2025)
Pharmacokinetic parameters of bictegravir in breastmilk of healthy, lactating volunteers without HIV after a single dose of 50 mg (co‐formulated with emtricitabine 200 mg and tenofovir alafenamide 25 mg)
by: L. Van Der Wekken‐Pas, et al.
Published: (2025)
by: L. Van Der Wekken‐Pas, et al.
Published: (2025)
Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover‐design trial
by: Alexander Hincker, et al.
Published: (2024)
by: Alexander Hincker, et al.
Published: (2024)
An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults
by: Sven C. van Dijkman, et al.
Published: (2026)
by: Sven C. van Dijkman, et al.
Published: (2026)
Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study
by: Yuhao Wang, et al.
Published: (2025)
by: Yuhao Wang, et al.
Published: (2025)
Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies
by: Alexandra A. J. Sillé, et al.
Published: (2026)
by: Alexandra A. J. Sillé, et al.
Published: (2026)
Model‐based precision dosing and remedial dosing recommendations for delayed or missed doses of isoniazid in Chinese patients with tuberculosis
by: Jin‐Meng Li, et al.
Published: (2024)
by: Jin‐Meng Li, et al.
Published: (2024)
Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease
by: Muhammad Waqas Sadiq, et al.
Published: (2024)
by: Muhammad Waqas Sadiq, et al.
Published: (2024)
Establishing reference ranges for circulating biomarkers of drug‐induced liver injury in healthy human volunteers 1
by: Andrea L. Jorgensen, et al.
Published: (2024)
by: Andrea L. Jorgensen, et al.
Published: (2024)
Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants
by: Jean‐Yves Gillon, et al.
Published: (2025)
by: Jean‐Yves Gillon, et al.
Published: (2025)
A phase I study to evaluate the safety, tolerance and pharmacokinetics of anti‐Shiga toxin hyperimmune equine F (ab′)2 fragments in healthy volunteers
by: Yanina Hiriart, et al.
Published: (2024)
by: Yanina Hiriart, et al.
Published: (2024)
A randomized phase I study of the safety and pharmacokinetics of BI 1291583 in healthy Japanese male subjects
by: Yusuke Tadayasu, et al.
Published: (2024)
by: Yusuke Tadayasu, et al.
Published: (2024)
Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individuals
by: Chen Xia, et al.
Published: (2026)
by: Chen Xia, et al.
Published: (2026)
Tolerability and pharmacokinetics of leritrelvir in Chinese participants with severe renal impairment and healthy matched control subjects
by: Zi‐yi Zhou, et al.
Published: (2026)
by: Zi‐yi Zhou, et al.
Published: (2026)
Letter to the Editor of the British Journal of Clinical Pharmacology Re: van Iersel et al. (2026)—Why do healthy volunteers participate in clinical trials? doi: https://doi.org/10.1002/bcp.70499
by: Kasra Shakeri‐Nejad, et al.
Published: (2026)
by: Kasra Shakeri‐Nejad, et al.
Published: (2026)
Single‐dose pharmacokinetics and safety of ACC017, a novel HIV integrase inhibitor, in healthy adult participants: A first‐in‐human study
by: C. Hu, et al.
Published: (2025)
by: C. Hu, et al.
Published: (2025)
A phase 1, randomized, crossover trial to assess the effect of itraconazole on the pharmacokinetics of dordaviprone in healthy adults
by: Shamia L. Faison, et al.
Published: (2025)
by: Shamia L. Faison, et al.
Published: (2025)
Current evidence and insights on single vs. double dose of basiliximab in adult solid organ transplant recipients: A systematic review
by: Alessio Provenzani, et al.
Published: (2025)
by: Alessio Provenzani, et al.
Published: (2025)
Interindividual variability in olanzapine steady‐state concentrations in Chinese: exploring single nucleotide polymorphisms of metabolic enzymes
by: Zhou Wan, et al.
Published: (2025)
by: Zhou Wan, et al.
Published: (2025)
Safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of HRS‐1893, a cardiac myosin inhibitor, in healthy subjects
by: Kexu Yang, et al.
Published: (2026)
by: Kexu Yang, et al.
Published: (2026)
Temporal effects of errors in estimating kidney function after critical illness on drug dosing categories
by: Ryusei Mikami, et al.
Published: (2025)
by: Ryusei Mikami, et al.
Published: (2025)
Model‐informed vancomycin precision dosing by population pharmacokinetics combined with machine learning algorithms
by: Lei Shi, et al.
Published: (2026)
by: Lei Shi, et al.
Published: (2026)
Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending‐dose study in healthy young men
by: Christian Friedrich, et al.
Published: (2024)
by: Christian Friedrich, et al.
Published: (2024)
Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period
by: Hui Yu, et al.
Published: (2026)
by: Hui Yu, et al.
Published: (2026)
An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects
by: James Goodman, et al.
Published: (2025)
by: James Goodman, et al.
Published: (2025)
Model‐informed dose selection for an investigational human epidermal growth factor receptor 2 antibody–drug conjugate FS‐1502 in patients with human epidermal growth factor receptor 2‐expressing advanced malignant solid tumours
by: Yi Sun, et al.
Published: (2024)
by: Yi Sun, et al.
Published: (2024)
Effect of fluconazole on the pharmacokinetics of ainuovirine in healthy adult subjects
Published: (2024)
Published: (2024)
Comparing the efficacy of efgartigimod and intravenous immunoglobulin on AQP4‐IgG‐positive neuromyelitis optica spectrum disorder during acute attacks
by: Jia Liu, et al.
Published: (2025)
by: Jia Liu, et al.
Published: (2025)
Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection
by: Albin A. M. Leding, et al.
Published: (2025)
by: Albin A. M. Leding, et al.
Published: (2025)
The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial
by: Alexandra Power‐Hays, et al.
Published: (2025)
by: Alexandra Power‐Hays, et al.
Published: (2025)
Practical dose ranges supporting target vancomycin exposure with AUC‐guided dosing in overweight and obese patients: A multicentre retrospective study
by: Aiju Endo, et al.
Published: (2026)
by: Aiju Endo, et al.
Published: (2026)
Methotrexate toxicity and glucarpidase: A call for dose optimization
by: Arjen Koppen, et al.
Published: (2025)
by: Arjen Koppen, et al.
Published: (2025)
Determination of the optimal obesity‐adjusted dosing weight for enoxaparin
by: Gregory W. Roberts, et al.
Published: (2024)
by: Gregory W. Roberts, et al.
Published: (2024)
Evaluation of the effect of CYP2D6 and OCT1 polymorphisms on the pharmacokinetics of tramadol: Implications for clinical safety and dose rationale in paediatric chronic pain
by: Paul Healy, et al.
Published: (2024)
by: Paul Healy, et al.
Published: (2024)
AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma
by: Anna Lundahl, et al.
Published: (2025)
by: Anna Lundahl, et al.
Published: (2025)
Characterizing local and systemic exposure to clobetasol propionate in healthy subjects and patients with atopic dermatitis
by: Janna K. Duong, et al.
Published: (2025)
by: Janna K. Duong, et al.
Published: (2025)
Concentration‐QTc analysis of soticlestat in healthy adults: An alternative to a thorough QT study
by: Wei Yin, et al.
Published: (2024)
by: Wei Yin, et al.
Published: (2024)
Similar Items
-
Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers
by: Lisanne K. A. Neijenhuis, et al.
Published: (2026) -
Effects on cerebral blood flow after single doses of the β2 agonist, clenbuterol, in healthy volunteers and patients with mild cognitive impairment or Parkinson's disease
by: Thomas Lodeweyckx, et al.
Published: (2024) -
Why do healthy volunteers participate in clinical trials?
by: Thijs van Iersel, et al.
Published: (2026) -
Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies
by: Yuji Kumagai, et al.
Published: (2025) -
Pharmacokinetic parameters of bictegravir in breastmilk of healthy, lactating volunteers without HIV after a single dose of 50 mg (co‐formulated with emtricitabine 200 mg and tenofovir alafenamide 25 mg)
by: L. Van Der Wekken‐Pas, et al.
Published: (2025)