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| Main Authors: | , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1002/bies.70029 |
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Table of Contents:
- Current and Future Landscape of SERCAs' Functions in Non‐Excitatory Cells and Diseases Jingyan Yu Hongyu Wang Mengqian Ding Xiuling Zhao Xiaoning Zhang BioEssays AbstractCalcium (Ca2+) signaling as the primary intracellular second messenger orchestrates a myriad of physiological processes. Maintaining Ca2+ homeostasis relies on Ca2+ channels, pumps, exchangers, and buffers. Sarco/endoplasmic reticulum Ca2+‐ATPases (SERCAs or ATP2A) encoded by ATP2A1, ATP2A2, or ATP2A3 are primary Ca2+ pumps localized on the endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR) that actively sequester Ca2+ from the cytoplasm back to the ER/SR, thereby preventing the detrimental overload of cytoplasmic Ca2+ concentration. Recent studies have highlighted the significant roles and the underlying mechanisms of SERCAs in non‐excitatory cells such as those within epithelial, adipose, immune, and reproductive systems or tissues. This article aims to provide a comprehensive summary of the functional characteristics and regulatory mechanisms of the SERCA family, with a particular focus on the latest research concerning their roles and mechanisms in various non‐excitatory cells and related cancers. This work will provide insight into understanding the Ca2+ signaling regulatory networks mediated by SERCAs and their implications for the diagnosis and treatment of Ca2+ dyshomeostasis‐related diseases and propose potentially constructive suggestions for the direction of research around Ca2+ signaling transductions, as well as guiding strategies for disease diagnosis, treatment, and drug development by targeting SERCAs. 10.1002/bies.70029 http://onlinelibrary.wiley.com/termsAndConditions#vor