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| Format: | Artículo Open Access |
| Publié: |
Wiley
2025
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| Accès en ligne: | https://onlinelibrary.wiley.com/doi/10.1002/bies.70100 |
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- Hybrid Legacies: Evolutionary Consequences of Neandertal Introgression and Implications for Autism Emily L. Casanova Trenton W. Holliday BioEssays ABSTRACT Recent work has shown that a subset of Neandertal‐derived single‐nucleotide polymorphisms (SNP) seems to be playing roles in autism susceptibility. We review this exciting research, as well as the known history of human migrations and interbreeding events between Homo sapiens and Neandertals, all while placing the current work within the context of hybrid dysgenesis and genetic incompatibilities. In addition to these “pushing” factors (purifying selection), we also explore potential “pulling” factors (positive selection), such as antagonistic pleiotropy and balanced polymorphism, which may influence the retention of otherwise weakly deleterious variants within the modern human genome. This work, along with other studies exploring associations between Neandertal‐derived alleles and other neurodivergent conditions, has significant implications for human brain evolution as well as modern human health. 10.1002/bies.70100 http://onlinelibrary.wiley.com/termsAndConditions#vor