Enhancement of Recombinant Adeno‐Associated Virus Production in HEK293 Cells by Application of Small Molecule Additives and Genetic Regulation Based on Perfusion Technique
Fuente:
Wiley Open Access
Guardado en:
| Autores principales: | Yang Sun, Tingqi Yang, Xiaotong Liu, Jianqi Nie, Kuiqi Jin, Hua Li, Pei Zhou, Yinbiao Xu, Yupeng Liu, Zhonghu Bai |
|---|---|
| Formato: | Artículo Open Access |
| Publicado: |
Wiley
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins
por: He Ren, et al.
Publicado: (2025)
por: He Ren, et al.
Publicado: (2025)
Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications
por: Pranay Ladiwala, et al.
Publicado: (2025)
por: Pranay Ladiwala, et al.
Publicado: (2025)
Comparative Analysis of HEK293 Genomic Variability
por: Georg Smesnik, et al.
Publicado: (2025)
por: Georg Smesnik, et al.
Publicado: (2025)
Improving Aggregation Control of Recombinant Adeno‐Associated Virus Serotype 2 (rAAV2) With Small Sugars and Ionic Salts
por: Alexander Burns, et al.
Publicado: (2025)
por: Alexander Burns, et al.
Publicado: (2025)
Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures
por: Carolin‐Isabel Kahlig, et al.
Publicado: (2024)
por: Carolin‐Isabel Kahlig, et al.
Publicado: (2024)
Expression of Viral DNA Polymerase in Synthetic Recombinant Adeno‐Associated Virus Producer Cell Line Enhances Full Particle Productivity
por: Yu‐Chieh Lin, et al.
Publicado: (2024)
por: Yu‐Chieh Lin, et al.
Publicado: (2024)
Virus Filtration Development for Adeno‐Associated Virus‐Based Gene Therapy Products
por: FNU Namila, et al.
Publicado: (2025)
por: FNU Namila, et al.
Publicado: (2025)
Uncovering Growth‐Inhibitory Metabolic Byproducts in HEK293 Fed‐Batch Cultures and Strategies for Their Control
por: Cameron Harrington, et al.
Publicado: (2025)
por: Cameron Harrington, et al.
Publicado: (2025)
Multivariate data analysis on multisensor measurement for inline process monitoring of adenovirus production in HEK293 cells
por: Xingge Xu, et al.
Publicado: (2024)
por: Xingge Xu, et al.
Publicado: (2024)
Multi‐omics kinetic analysis of recombinant adeno‐associated virus production by plasmid transfection of HEK293 cells
por: Min Lu, et al.
Publicado: (2024)
por: Min Lu, et al.
Publicado: (2024)
Towards a Platform Chromatography Purification Process for Adeno‐Associated Virus (AAV)
por: Alexandra Bogdanovic, et al.
Publicado: (2025)
por: Alexandra Bogdanovic, et al.
Publicado: (2025)
Enhanced Recombinant Adeno‐Associated Virus (rAAV) Biomanufacturing: Design of Experiment (DOE) Enabled Transfection Optimization for Maximum Full Capsid Yield and Robust Scale‐Up
por: Alexandra Bogdanovic, et al.
Publicado: (2026)
por: Alexandra Bogdanovic, et al.
Publicado: (2026)
Deep hybrid modeling of a HEK293 process: Combining long short‐term memory networks with first principles equations
por: João R. C. Ramos, et al.
Publicado: (2024)
por: João R. C. Ramos, et al.
Publicado: (2024)
Accelerated Adeno Associated Virus Upstream Process Development From High‐Throughput Systems to Clinical Scale
por: Angela Andaluz, et al.
Publicado: (2025)
por: Angela Andaluz, et al.
Publicado: (2025)
Cas‐CLOVER‐mediated knockout of STAT1: A novel approach to engineer packaging HEK‐293 cell lines used for rAAV production
por: Peter Andorfer, et al.
Publicado: (2024)
por: Peter Andorfer, et al.
Publicado: (2024)
Correction to Accelerated Adeno Associated Virus Upstream Process Development From High‐Throughput Systems to Clinical Scale
Publicado: (2025)
Publicado: (2025)
Modulation of the cell cycle and inhibition of histone deacetylases by small molecules increase recombinant adeno‐associated virus productivity across different HEK293 cell lines
por: Niklas Krämer, et al.
Publicado: (2025)
por: Niklas Krämer, et al.
Publicado: (2025)
Rapid At‐Line AAVX Affinity HPLC: Enabling Process Analytical Technology for Bioprocess Development of Adeno‐Associated Virus Vectors
por: Jakob Heckel, et al.
Publicado: (2025)
por: Jakob Heckel, et al.
Publicado: (2025)
M/G‐Ratio‐Tuned Calcium Alginate Hydrogel Microcarrier for Controlled Delivery of Adeno‐Associated Virus for Gene Therapy
por: Aiki Hioki, et al.
Publicado: (2025)
por: Aiki Hioki, et al.
Publicado: (2025)
Intracellular Antibody Levels Predict Secretion Efficiency in HEK293T Cells Expressing a Chimeric Anti‐CD99 Antibody from a Single‐Expression Plasmid
por: Manatchanok Chinakarapong, et al.
Publicado: (2025)
por: Manatchanok Chinakarapong, et al.
Publicado: (2025)
Enhancement of Chondrogenesis by a Microcavitary Hydrogel Coculture System Synergizing With SDF‐1α and TGF‐Β3
por: Qian Pan, et al.
Publicado: (2025)
por: Qian Pan, et al.
Publicado: (2025)
Recent Research on Chondrocyte Dedifferentiation and Insights for Regenerative Medicine
por: Weixian Su, et al.
Publicado: (2024)
por: Weixian Su, et al.
Publicado: (2024)
Optimizated Prolyl‐4‐Hydroxylase Expression in Komagataella phaffii Enables Efficient Triple‐Helix Formation of Recombinant Human Collagen
por: Nan Wang, et al.
Publicado: (2025)
por: Nan Wang, et al.
Publicado: (2025)
Use of Split‐Intein Proteins to Design a Small Molecule Biosensor in Plants
por: Brandon A. Boone, et al.
Publicado: (2025)
por: Brandon A. Boone, et al.
Publicado: (2025)
Gut Microbial Genetic Variation Regulates Host Reproduction
por: Xiaoyue Ding, et al.
Publicado: (2025)
por: Xiaoyue Ding, et al.
Publicado: (2025)
Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production
por: Chethana Janardhana Gadiyar, et al.
Publicado: (2025)
por: Chethana Janardhana Gadiyar, et al.
Publicado: (2025)
Developments in the Production of Recombinant Monoclonal Antibodies
por: Debajyoti Saha, et al.
Publicado: (2025)
por: Debajyoti Saha, et al.
Publicado: (2025)
Genetic Mapping and Functional Characterisation of GhCUP Regulating Leaf Curling in Cotton
por: Haonan Shi, et al.
Publicado: (2025)
por: Haonan Shi, et al.
Publicado: (2025)
Adaptable Manufacturing and Biofabrication of Milliscale Organ Chips With Perfusable Vascular Beds
por: Charles Ethan Byrne, et al.
Publicado: (2024)
por: Charles Ethan Byrne, et al.
Publicado: (2024)
Strategies to Express Soluble Recombinant Apostichopus japonicus Phospholipase A 2 in Escherichia coli and Its Activities
por: Jia Li, et al.
Publicado: (2025)
por: Jia Li, et al.
Publicado: (2025)
Development of a Small‐Scale Continuous Virus Filtration Model That Incorporates Inline Spiking and Mixing
por: Ioana Pintescu, et al.
Publicado: (2025)
por: Ioana Pintescu, et al.
Publicado: (2025)
ZmmiR1432 ‐ ZmCML21 ‐ ZmPMA2 Module Affects Maize Low Phosphate Tolerance via Regulating Organic Acid Secretion
por: Laming Pei, et al.
Publicado: (2025)
por: Laming Pei, et al.
Publicado: (2025)
Development of a chemiluminescence detection technique for malachite green
por: Yang Sun, et al.
Publicado: (2024)
por: Yang Sun, et al.
Publicado: (2024)
Porin‐Independent Uptake of Small Molecule Antibiotics Facilitated by Escherichia coli Outer Membrane Vesicles
por: Meishan Wu, et al.
Publicado: (2025)
por: Meishan Wu, et al.
Publicado: (2025)
Enhancement of acyl‐ CoA precursor supply for increased avermectin B1a production by engineering meilingmycin polyketide synthase and key primary metabolic pathway genes
por: Mengyao Yang, et al.
Publicado: (2024)
por: Mengyao Yang, et al.
Publicado: (2024)
Reconstructing an Inducible Homologous Recombination System in Ogataea Polymorpha
por: Nan Jia, et al.
Publicado: (2025)
por: Nan Jia, et al.
Publicado: (2025)
Development of a Ready‐To‐Use Bioluminescence Immunosensor for the One‐Step Sensitive Detection of Antibodies Against African Swine Fever Virus
por: Zhonghui Zhang, et al.
Publicado: (2025)
por: Zhonghui Zhang, et al.
Publicado: (2025)
Perfusion Process Intensification for Lentivirus Production Using a Novel Scale‐Down Model
por: Maximilian Klimpel, et al.
Publicado: (2024)
por: Maximilian Klimpel, et al.
Publicado: (2024)
An Additive‐Fabricated Biphasic Scaffold for Procedurally Promoting Bone Regeneration via Antioxidant and Osteogenesis
por: Chunyu Han, et al.
Publicado: (2024)
por: Chunyu Han, et al.
Publicado: (2024)
bZIP63.5 Regulates a Zinc‐Finger Mediated Detoxification Network in Trichoderma Harzianum for Enhanced Biocontrol of Alternaria alternata
por: Yongfeng Yang, et al.
Publicado: (2026)
por: Yongfeng Yang, et al.
Publicado: (2026)
Ejemplares similares
-
Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins
por: He Ren, et al.
Publicado: (2025) -
Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications
por: Pranay Ladiwala, et al.
Publicado: (2025) -
Comparative Analysis of HEK293 Genomic Variability
por: Georg Smesnik, et al.
Publicado: (2025) -
Improving Aggregation Control of Recombinant Adeno‐Associated Virus Serotype 2 (rAAV2) With Small Sugars and Ionic Salts
por: Alexander Burns, et al.
Publicado: (2025) -
Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures
por: Carolin‐Isabel Kahlig, et al.
Publicado: (2024)