Uncovering Growth‐Inhibitory Metabolic Byproducts in HEK293 Fed‐Batch Cultures and Strategies for Their Control
Fuente:
Wiley Open Access
Salvato in:
| Autori principali: | Cameron Harrington, Bhanu Chandra Mulukutla |
|---|---|
| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
Documenti analoghi
Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications
di: Pranay Ladiwala, et al.
Pubblicazione: (2025)
di: Pranay Ladiwala, et al.
Pubblicazione: (2025)
Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures
di: Carolin‐Isabel Kahlig, et al.
Pubblicazione: (2024)
di: Carolin‐Isabel Kahlig, et al.
Pubblicazione: (2024)
Comparative Analysis of HEK293 Genomic Variability
di: Georg Smesnik, et al.
Pubblicazione: (2025)
di: Georg Smesnik, et al.
Pubblicazione: (2025)
Enhancement of Recombinant Adeno‐Associated Virus Production in HEK293 Cells by Application of Small Molecule Additives and Genetic Regulation Based on Perfusion Technique
di: Yang Sun, et al.
Pubblicazione: (2025)
di: Yang Sun, et al.
Pubblicazione: (2025)
Cas‐CLOVER‐mediated knockout of STAT1: A novel approach to engineer packaging HEK‐293 cell lines used for rAAV production
di: Peter Andorfer, et al.
Pubblicazione: (2024)
di: Peter Andorfer, et al.
Pubblicazione: (2024)
Multi‐Omics Reveals Impact of Hypoxia on Lactate Metabolic Switch and Monoclonal Antibody Production in CHO Fed‐Batch Cultivation
di: Pei Yin, et al.
Pubblicazione: (2025)
di: Pei Yin, et al.
Pubblicazione: (2025)
Intracellular Antibody Levels Predict Secretion Efficiency in HEK293T Cells Expressing a Chimeric Anti‐CD99 Antibody from a Single‐Expression Plasmid
di: Manatchanok Chinakarapong, et al.
Pubblicazione: (2025)
di: Manatchanok Chinakarapong, et al.
Pubblicazione: (2025)
Enhanced Adeno‐Associated Virus Production in HEK293 Cells via Dual Inducible Control of Cap and Rep Proteins
di: He Ren, et al.
Pubblicazione: (2025)
di: He Ren, et al.
Pubblicazione: (2025)
Multivariate data analysis on multisensor measurement for inline process monitoring of adenovirus production in HEK293 cells
di: Xingge Xu, et al.
Pubblicazione: (2024)
di: Xingge Xu, et al.
Pubblicazione: (2024)
Multi‐omics kinetic analysis of recombinant adeno‐associated virus production by plasmid transfection of HEK293 cells
di: Min Lu, et al.
Pubblicazione: (2024)
di: Min Lu, et al.
Pubblicazione: (2024)
Deep hybrid modeling of a HEK293 process: Combining long short‐term memory networks with first principles equations
di: João R. C. Ramos, et al.
Pubblicazione: (2024)
di: João R. C. Ramos, et al.
Pubblicazione: (2024)
Modulation of the cell cycle and inhibition of histone deacetylases by small molecules increase recombinant adeno‐associated virus productivity across different HEK293 cell lines
di: Niklas Krämer, et al.
Pubblicazione: (2025)
di: Niklas Krämer, et al.
Pubblicazione: (2025)
Revolutionizing Caffeic Acid Production: Advanced Microbial Metabolic Engineering and Synthetic Biology Approaches
di: Jintao Lu, et al.
Pubblicazione: (2025)
di: Jintao Lu, et al.
Pubblicazione: (2025)
A Near Gap‐Free Haplotype‐Resolved Genome Assembly of Zoysia japonica Uncovers Intra‐Subgenomic Gene Expression and Regulatory Variation
di: Sae Hyun Lee, et al.
Pubblicazione: (2026)
di: Sae Hyun Lee, et al.
Pubblicazione: (2026)
Influence of Cell Physiological Status on the Intensified Fed‐Batch Cultures at Ultra‐High Seeding Density
di: Qingyuan Ran, et al.
Pubblicazione: (2025)
di: Qingyuan Ran, et al.
Pubblicazione: (2025)
A Growth‐Coupled Evolutionary Strategy Enhances Heme Biosynthesis in Saccharomyces cerevisiae
di: Seoyoon Bang, et al.
Pubblicazione: (2026)
di: Seoyoon Bang, et al.
Pubblicazione: (2026)
Cell Seeding Strategy Influences Metabolism and Differentiation Potency of Human Induced Pluripotent Stem Cells Into Pancreatic Progenitors
di: Hui Huang, et al.
Pubblicazione: (2025)
di: Hui Huang, et al.
Pubblicazione: (2025)
Bacterial Glutamine Synthetases as a Novel Metabolic Selection Marker to Improve CHO Cell Culture Performance Through Selection Stringency Modulation
di: Daniel Heinzelmann, et al.
Pubblicazione: (2025)
di: Daniel Heinzelmann, et al.
Pubblicazione: (2025)
Self‐Produced Brain‐Like ECM From 3D‐Cultured Dermal Fibroblasts Enhances Neuronal Growth and Survival
di: Vincent Roy, et al.
Pubblicazione: (2025)
di: Vincent Roy, et al.
Pubblicazione: (2025)
A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction
di: Keqi Wang, et al.
Pubblicazione: (2026)
di: Keqi Wang, et al.
Pubblicazione: (2026)
Context‐Specific Genome‐Scale Metabolic Modeling to Unravel the Metabolic Rewiring in Human Diseases
di: Satyajit Beura, et al.
Pubblicazione: (2026)
di: Satyajit Beura, et al.
Pubblicazione: (2026)
AI‐Driven Quality Monitoring and Control in Stem Cell Cultures: A Comprehensive Review
di: Rohan Singh, et al.
Pubblicazione: (2025)
di: Rohan Singh, et al.
Pubblicazione: (2025)
Single‐Batch Expression of an Experimental Recombinant Snakebite Antivenom Based on an Oligoclonal Mixture of Human Monoclonal Antibodies
di: Anna C. Adams, et al.
Pubblicazione: (2024)
di: Anna C. Adams, et al.
Pubblicazione: (2024)
ZmTH1 Is Vital for Healthy Plant Growth and Promotes Cold/Drought Tolerance by Regulating Thiamin Diphosphate‐Dependent Metabolisms in Maize
di: Tengfei Zhang, et al.
Pubblicazione: (2025)
di: Tengfei Zhang, et al.
Pubblicazione: (2025)
Metabolic Engineering of Saccharomyces cerevisiae for Fermentative Production of Heme
di: Hyun‐Jae Lee, et al.
Pubblicazione: (2024)
di: Hyun‐Jae Lee, et al.
Pubblicazione: (2024)
Microbial Biosynthesis of Natural Esters via Enzyme and Metabolic Engineering
di: Dianqi Yang, et al.
Pubblicazione: (2025)
di: Dianqi Yang, et al.
Pubblicazione: (2025)
Uncovering Convergent Pattern Recognition Receptors Recognising Phytophthora Across Plant Lineages
di: Yong Pei, et al.
Pubblicazione: (2025)
di: Yong Pei, et al.
Pubblicazione: (2025)
TaRIP2 Positively Regulates Wheat Pollen Wall Formation Through MYB80 ‐Controlled Lipid Metabolism
di: Ran Han, et al.
Pubblicazione: (2025)
di: Ran Han, et al.
Pubblicazione: (2025)
UV Mutagenesis Enhances DHA Biosynthesis in Schizochytrium sp. via Metabolic Reprogramming
di: Jing Wen, et al.
Pubblicazione: (2025)
di: Jing Wen, et al.
Pubblicazione: (2025)
Linker Peptide Engineering Combined With SA‐PVA Immobilization in Fed‐Batch Biocatalysis for High‐Efficiency Carcinine Synthesis
di: Man Zhao, et al.
Pubblicazione: (2025)
di: Man Zhao, et al.
Pubblicazione: (2025)
Metabolic engineering of Aspergillus niger for accelerated malic acid biosynthesis by improving NADPH availability
di: Na Wu, et al.
Pubblicazione: (2024)
di: Na Wu, et al.
Pubblicazione: (2024)
Biochemical and Metabolic Engineering of Saccharomyces cerevisiae for the Biosynthesis of Olivetolic Acid, a Key Cannabinoid Precursor
di: Kilan J. Schäfer, et al.
Pubblicazione: (2025)
di: Kilan J. Schäfer, et al.
Pubblicazione: (2025)
Transcriptional Downregulation of Methanol Metabolism Key Genes During Yeast Death in Engineered Pichia pastoris
di: Chenbo Wang, et al.
Pubblicazione: (2024)
di: Chenbo Wang, et al.
Pubblicazione: (2024)
Preparation of Thermosensitive Lignocellulose Hollow Fiber Membrane Grafted With PNIPAAm and Its Application as a Cell Culture Carrier in a RSOC Dynamic Culture
di: Jiaqi Liu, et al.
Pubblicazione: (2024)
di: Jiaqi Liu, et al.
Pubblicazione: (2024)
Metabolic Engineering of Komagataella phaffii and Process Optimization for Biosynthesis of 1,2,4‐Butanetriol From Xylose
di: Débora Trichez, et al.
Pubblicazione: (2025)
di: Débora Trichez, et al.
Pubblicazione: (2025)
The Impacts of Environmental Factors and Culture Conditions on the Transient Expression of Recombinant Protein in Nicotiana benthamiana Under Controlled Environments
di: Ryo Matsuda
Pubblicazione: (2025)
di: Ryo Matsuda
Pubblicazione: (2025)
Metabolic engineering of vitamin D3 in Solanaceae plants
di: Marianna Boccia, et al.
Pubblicazione: (2024)
di: Marianna Boccia, et al.
Pubblicazione: (2024)
Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell‐Derived Human Hepatocytes In Vitro Using Microfluidics Technology
di: Joana Saraiva Rodrigues, et al.
Pubblicazione: (2025)
di: Joana Saraiva Rodrigues, et al.
Pubblicazione: (2025)
Investigating Hepatic Glucose Metabolism in Insulin Resistance Cell Model Using 3D‐Printed Open Microfluidic Chip
di: Meng‐Meng Liu, et al.
Pubblicazione: (2025)
di: Meng‐Meng Liu, et al.
Pubblicazione: (2025)
Regulation of DNA Methylation in Peanut Leaves and Roots: Uncovering the Molecular Mechanisms for Increased Yield After Single‐Seed Sowing
di: Shikai Fan, et al.
Pubblicazione: (2025)
di: Shikai Fan, et al.
Pubblicazione: (2025)
Documenti analoghi
-
Unraveling Cytotoxicity in HEK293 Cells During Recombinant AAV Production for Gene Therapy Applications
di: Pranay Ladiwala, et al.
Pubblicazione: (2025) -
Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures
di: Carolin‐Isabel Kahlig, et al.
Pubblicazione: (2024) -
Comparative Analysis of HEK293 Genomic Variability
di: Georg Smesnik, et al.
Pubblicazione: (2025) -
Enhancement of Recombinant Adeno‐Associated Virus Production in HEK293 Cells by Application of Small Molecule Additives and Genetic Regulation Based on Perfusion Technique
di: Yang Sun, et al.
Pubblicazione: (2025) -
Cas‐CLOVER‐mediated knockout of STAT1: A novel approach to engineer packaging HEK‐293 cell lines used for rAAV production
di: Peter Andorfer, et al.
Pubblicazione: (2024)