Teaching biologics design using molecular modeling and simulations
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| Natura: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867020805541462017 |
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| author | Andrew Phillips Anusha Srinivas Ilina Prentoska Margaret O'Dea Matthew Kustrup Sarah Hurley Savannah Bruno Vy Nguyen Pin‐Kuang Lai |
| author_facet | Andrew Phillips Anusha Srinivas Ilina Prentoska Margaret O'Dea Matthew Kustrup Sarah Hurley Savannah Bruno Vy Nguyen Pin‐Kuang Lai Andrew Phillips Anusha Srinivas Ilina Prentoska Margaret O'Dea Matthew Kustrup Sarah Hurley Savannah Bruno Vy Nguyen Pin‐Kuang Lai |
| collection | Wiley Open Access |
| contents | Teaching biologics design using molecular modeling and simulations Andrew Phillips Anusha Srinivas Ilina Prentoska Margaret O'Dea Matthew Kustrup Sarah Hurley Savannah Bruno Vy Nguyen Pin‐Kuang Lai Biochemistry and Molecular Biology Education AbstractTeaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester‐long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students. 10.1002/bmb.21813 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/bmb.21813 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_bmb_21813 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Teaching biologics design using molecular modeling and simulations Andrew Phillips Anusha Srinivas Ilina Prentoska Margaret O'Dea Matthew Kustrup Sarah Hurley Savannah Bruno Vy Nguyen Pin‐Kuang Lai Biochemistry and Molecular Biology Education Teaching biologics design using molecular modeling and simulations Andrew Phillips Anusha Srinivas Ilina Prentoska Margaret O'Dea Matthew Kustrup Sarah Hurley Savannah Bruno Vy Nguyen Pin‐Kuang Lai Biochemistry and Molecular Biology Education AbstractTeaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester‐long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students. 10.1002/bmb.21813 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Teaching biologics design using molecular modeling and simulations |
| topic | Biochemistry and Molecular Biology Education |
| url | https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.21813 |