Mental health and its consequences in people living with HIV: A network approach
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Wiley Open Access
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Elise M. G. Meeder Louise E. van Eekeren Marc J. T. Blaauw Albert L. Groenendijk Wilhelm A. J. W. Vos Jan van Lunzen Leo A. B. Joosten Mihai G. Netea Quirijn de Mast Willem L. Blok Annelies Verbon Marvin A. H. Berrevoets Vasiliki Matzaraki Andre J. A. M. van der Ven Arnt F. A. Schellekens |
| author_facet | Elise M. G. Meeder Louise E. van Eekeren Marc J. T. Blaauw Albert L. Groenendijk Wilhelm A. J. W. Vos Jan van Lunzen Leo A. B. Joosten Mihai G. Netea Quirijn de Mast Willem L. Blok Annelies Verbon Marvin A. H. Berrevoets Vasiliki Matzaraki Andre J. A. M. van der Ven Arnt F. A. Schellekens Elise M. G. Meeder Louise E. van Eekeren Marc J. T. Blaauw Albert L. Groenendijk Wilhelm A. J. W. Vos Jan van Lunzen Leo A. B. Joosten Mihai G. Netea Quirijn de Mast Willem L. Blok Annelies Verbon Marvin A. H. Berrevoets Vasiliki Matzaraki Andre J. A. M. van der Ven Arnt F. A. Schellekens |
| collection | Wiley Open Access |
| contents | Mental health and its consequences in people living with HIV: A network approach Elise M. G. Meeder Louise E. van Eekeren Marc J. T. Blaauw Albert L. Groenendijk Wilhelm A. J. W. Vos Jan van Lunzen Leo A. B. Joosten Mihai G. Netea Quirijn de Mast Willem L. Blok Annelies Verbon Marvin A. H. Berrevoets Vasiliki Matzaraki Andre J. A. M. van der Ven Arnt F. A. Schellekens Brain and Behavior Abstract Objectives Psychiatric symptoms occur frequently in people living with human immunodeficiency virus (PLWH), which may affect quality of life, sexual risk behavior, and adherence to antiretroviral therapy (ART). Data from large cohorts are limited, and symptoms are often analyzed in isolation. Therefore, we applied a network analysis to assess the interrelatedness of mental health indicators in a large cohort of PLWH. Methods We included 1615 PLWH on ART. Participants reported on the severity of depression, anxiety, impulsivity, substance use, quality of life, sexual risk behavior, and ART adherence. An Ising network model was constructed to analyze interrelations between mental health indicators and connections with clinical consequences. Results Our network analysis revealed that symptoms of depression, anxiety, and indicators of impulsivity were interrelated. Substance use was prevalent and strongly connected with sexual risk behavior. Quality of life was most strongly connected with symptoms of depression. Unexpectedly, ART adherence did not display connections with any of the mental health indicators. Conclusion In PLWH, the interrelatedness between symptoms of depression and anxiety and indicators of impulsivity is high. Mainly, depressive symptoms seem to impact quality of life, which warrants attention for depression in PLWH. We did not observe evidence for the common assumption that patients suffering from psychiatric symptoms are less adherent to HIV treatment. 10.1002/brb3.70021 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/brb3.70021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_brb3_70021 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Mental health and its consequences in people living with HIV: A network approach Elise M. G. Meeder Louise E. van Eekeren Marc J. T. Blaauw Albert L. Groenendijk Wilhelm A. J. W. Vos Jan van Lunzen Leo A. B. Joosten Mihai G. Netea Quirijn de Mast Willem L. Blok Annelies Verbon Marvin A. H. Berrevoets Vasiliki Matzaraki Andre J. A. M. van der Ven Arnt F. A. Schellekens Brain and Behavior Mental health and its consequences in people living with HIV: A network approach Elise M. G. Meeder Louise E. van Eekeren Marc J. T. Blaauw Albert L. Groenendijk Wilhelm A. J. W. Vos Jan van Lunzen Leo A. B. Joosten Mihai G. Netea Quirijn de Mast Willem L. Blok Annelies Verbon Marvin A. H. Berrevoets Vasiliki Matzaraki Andre J. A. M. van der Ven Arnt F. A. Schellekens Brain and Behavior Abstract Objectives Psychiatric symptoms occur frequently in people living with human immunodeficiency virus (PLWH), which may affect quality of life, sexual risk behavior, and adherence to antiretroviral therapy (ART). Data from large cohorts are limited, and symptoms are often analyzed in isolation. Therefore, we applied a network analysis to assess the interrelatedness of mental health indicators in a large cohort of PLWH. Methods We included 1615 PLWH on ART. Participants reported on the severity of depression, anxiety, impulsivity, substance use, quality of life, sexual risk behavior, and ART adherence. An Ising network model was constructed to analyze interrelations between mental health indicators and connections with clinical consequences. Results Our network analysis revealed that symptoms of depression, anxiety, and indicators of impulsivity were interrelated. Substance use was prevalent and strongly connected with sexual risk behavior. Quality of life was most strongly connected with symptoms of depression. Unexpectedly, ART adherence did not display connections with any of the mental health indicators. Conclusion In PLWH, the interrelatedness between symptoms of depression and anxiety and indicators of impulsivity is high. Mainly, depressive symptoms seem to impact quality of life, which warrants attention for depression in PLWH. We did not observe evidence for the common assumption that patients suffering from psychiatric symptoms are less adherent to HIV treatment. 10.1002/brb3.70021 http://creativecommons.org/licenses/by/4.0/ |
| title | Mental health and its consequences in people living with HIV: A network approach |
| topic | Brain and Behavior |
| url | https://onlinelibrary.wiley.com/doi/10.1002/brb3.70021 |